ArticleBMC ophthalmology2020
Systemic and ocular diseases associated with the development of diabetic macular edema among Japanese patients with diabetes mellitus.
Article in BMC ophthalmology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 13 citations in OpenAlex.
- Osteoarthritis among individuals with diabetes mellitus in Saudi Arabia.Journal of family medicine and primary care · 2026Article
- Genome-Wide Association Study to Identify Genetic Variants Associated With Diabetic Maculopathy.Investigative ophthalmology & visual science · 2025Article
- Diabetic macular edema (DME): dissecting pathogenesis, prognostication, diagnostic modalities along with current and futuristic therapeutic insights.International journal of retina and vitreous · 2024Review
- Wide-Field Optical Coherence Tomography in Patients with Diabetic Macular Edema.Journal of clinical medicine · 2024Article
- Association between the response of intravitreal antivascular endothelial growth factor injection and systemic factors of diabetic macular edema.BMC ophthalmology · 2024Article
- Intravitreal injection of Conbercept combined with micropulse laser therapy enhances clinical efficacy in patients with diabetic macular edema.American journal of translational research · 2023Article
- Incidence of interventions for diabetic retinopathy and serious lower-limb complications and its related factors in patients with type 2 diabetes using a real-world large claims database.Diabetology international · 2022Article
- Variations in Electronic Health Record-Based Definitions of Diabetic Retinopathy Cohorts: A Literature Review and Quantitative Analysis.Ophthalmology scienceArticle
- Optical coherence tomography findings in patients with diabetic macular edema: A retrospective analysis.Oman journal of ophthalmologyArticle
- Evaluation of the monotherapy effect of crocin on mild-to-moderate diabetic retinopathy: A randomized clinical trial.Avicenna journal of phytomedicineArticle
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDiabetic macular edema (DME) causes severe vision loss among patients with diabetes mellitus (DM). We aimed to investigate systemic and ocular diseases associated with the development of DME in a Japanese population.
methodsA total of 3.11 million Japanese subjects who were registered in the database of the Japan Medical Data Center from 2005 to 2014 were analyzed. Subjects with DM were defined as individuals who had been prescribed any therapeutic medications for DM, and associated diseases were analyzed. The periods assessed were one year before the development of DME among patients with DME and one year before the last visit to an ophthalmic clinic among patients without DME.
resultsA total of 17,403 patients with DM satisfied the inclusion and exclusion criteria, and 420 patients developed DME. Univariate analysis revealed significant associations between 55 diseases, including 39 systemic and 16 ocular diseases, and DME development. Logistic analysis identified 21 systemic diseases and 10 ocular diseases as significant factors associated with DME development.
conclusionVarious types of systemic and ocular diseases are associated with DME development. Subjects with DM who present these risk factors must be carefully monitored to prevent visual impairment.
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