Evidence map›Paper›PMID 32727394›Full record

ArticleBMC gastroenterology2020

Clinical and genomic characteristics of mucosal signet-ring cell carcinoma in Helicobacter pylori-uninfected stomach.

Mariko Kiso, Yuji Urabe, Masanori Ito, Kazuhiko Masuda, Tomoyuki Boda, Takahiro Kotachi, Kosaku Hata, Naoki Yorita, Naoko Nagasaki, Madina Abduwali and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC gastroenterology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. A mathematical simulation model to determine the optimal endoscopic screening strategy for detection of H. pylori-naïve gastric neoplasms.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2024
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Indolent feature of Helicobacter pylori-uninfected intramucosal signet ring cell carcinomas with CDH1 mutations.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Mariko KisoDepartment of Gastroenterology and Metabolism, Hiroshima University, Hiroshima, Japan.
Yuji UrabeDepartment of Medicine and Molecular Science, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan. beyan13@hiroshima-u.ac.jp.ORCID http://orcid.org/0000-0003-0942-1541
Masanori ItoDepartment of General Internal Medicine, Hiroshima University Hospital, Hiroshima, Japan.
Kazuhiko MasudaDepartment of Gastroenterology, Miyoshi Central Hospital, Hiroshima, Japan.
Tomoyuki BodaDepartment of Endoscopy, Hiroshima University Hospital, Hiroshima, Japan.
Takahiro KotachiDepartment of Endoscopy, Hiroshima University Hospital, Hiroshima, Japan.
Kosaku HataDepartment of Gastroenterology, Chugoku Rosai Hospital, Hiroshima, Japan.
Naoki YoritaDepartment of Gastroenterology and Metabolism, Hiroshima University, Hiroshima, Japan.
Naoko NagasakiDepartment of Gastroenterology and Metabolism, Hiroshima University, Hiroshima, Japan.
Madina AbduwaliDepartment of Gastroenterology and Metabolism, Hiroshima University, Hiroshima, Japan.
Yuich HiyamaDepartment of Gastroenterology and Metabolism, Hiroshima University, Hiroshima, Japan.
Shiro OkaDepartment of Gastroenterology and Metabolism, Hiroshima University, Hiroshima, Japan.
Shinji TanakaDepartment of Endoscopy, Hiroshima University Hospital, Hiroshima, Japan.
Kazuaki ChayamaDepartment of Gastroenterology and Metabolism, Hiroshima University, Hiroshima, Japan.
Hiroshima University · JPHiroshima University Hospital · JPChugoku Rosai Hospital · JPMiyoshi Kasei (Japan) · JP

Funding

Tsuchiya Memorial Medical Foundation 33-3
6 · The paper itself

Abstract

backgroundGastric cancer develops even in Helicobacter pylori(H. pylori)-uninfected patients and its typical histological feature is signet ring cell carcinoma (SRCC) within the mucosal layer. However, the biological characteristics of SRCC remain unclear. We aimed to clarify the pathological and genetic features of SRCC in H. pylori-uninfected patients.

methodsSeventeen H. pylori-uninfected patients with mucosal SRCCs were enrolled and their clinicopathological characteristics were compared with those of H. pylori-infected patients with mucosal SRCCs. Seven SRCCs without H. pylori-infected, including two invasive SRCCs, and seven H. pylori-infected SRCCs were subjected to a genetic analysis using next-generation sequencing.

resultsH. pylori-uninfected patients with mucosal SRCCs revealed male dominancy and a significantly higher prevalence of smokers among them as compared with the H. pylori-infected patients with SRCC. A CDH1 mutation (frame shift indel) was detected in one H. pylori-uninfected cancer not only in the mucosal SRCC but also in the invasive portion. A TP53 mutation was detected in one SRCC without H. pylori-infected. In the control group, ARID1A and TP53 mutations were detected in one SRCC each. The C to A mutation, which is a characteristic smoking-induced mutation, was not found in any of the samples.

conclusionsSome SRCCs in H. pylori-uninfected patients may have a malignant potential similar to that of SRCCs in H. pylori-infected patients. Smoking may not be the main carcinogenic factor for the development of SRCCs among the H. pylori-uninfected patients.

Indexed as

Carcinoma, Signet Ring CellHelicobacter InfectionsHelicobacter pyloriStomach NeoplasmsGastric MucosaGenomicsHumansMaleHelicobacter pyloriNext generation sequenceSignet ring cell carcinomaSmokingUninfected

Identifiers

PMID32727394
PMCPMC7391816
OpenAlexW3045752182

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.