Evidence map›Paper›PMID 32727296›Full record

ReviewNeurological research2023

Neuroprosthesis for individuals with spinal cord injury.

Kevin L Kilgore, Kimberly D Anderson, P Hunter Peckham

Open access · bronzeAbstract readReview
In one paragraph

Review in Neurological research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 31 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Kevin L KilgoreDepartment of Physical Medicine and Rehabilitation, MetroHealth System, Cleveland, OH, USA.
Kimberly D AndersonDepartment of Physical Medicine and Rehabilitation, MetroHealth System, Cleveland, OH, USA.ORCID 0000-0001-9252-161X
P Hunter PeckhamDepartment of Physical Medicine and Rehabilitation, MetroHealth System, Cleveland, OH, USA.
MetroHealth · US

Funding

Restoration of Grasp and Reach in Cervical Spinal Cord InjuryUH3NS103863 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI BRYDEN, ANNE, KILGORE, KEVIN L. · 2019 to 2024
$8.1M
Phase 2 study of the NNP for Grasp and Trunk in SCI: IDEG140225-11-13-2014R01FD005409 · FDA · CASE WESTERN RESERVE UNIVERSITY · PI KILGORE, KEVIN L. · 2016 to 2023
$2.0M
Restoration of Grasp and Reach in Cervical Spinal Cord InjuryUH2NS103863 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI PECKHAM, PAUL HUNTER · 2018 to 2018
$1.5M
Whole-body Neuroprosthetic Approach for Incomplete Cervical Spinal Cord InjuryI01RX001804 · VA · LOUIS STOKES CLEVELAND VA MEDICAL CENTER · PI KILGORE, KEVIN L. · 2015 to 2019
–
FDA HHS R01 FD005409NINDS NIH HHS UH2 NS103863NINDS NIH HHS UH3 NS103863RRD VA I01 RX001804
6 · The paper itself

Abstract

objectiveIndividuals who sustain a traumatic spinal cord injury (SCI) often have a loss of multiple body systems. Significant functional improvement can be gained by individual SCI through the use of neuroprostheses based on electrical stimulation. The most common actions produced are grasp, overhead reach, trunk posture, standing, stepping, bladder/bowel/sexual function, and respiratory functions.

methodsWe review the fundamental principles of electrical stimulation, which are established, allowing stimulation to be safely delivered through implanted devices for many decades. We review four common clinical applications for SCI, including grasp/reach, standing/stepping, bladder/bowel function, and respiratory functions. Systems used to implement these functions have many common features, but are also customized based on the functional goals of each approach. Further, neuroprosthetic systems are customized based on the needs of each user. RESULTS &

conclusionThe results to date show that implanted neuroprostheses can have a significant impact on the health, function, and quality of life for individuals with SCI. A key focus for the future is to make implanted neuroprostheses broadly available to the SCI population.

Indexed as

Electric Stimulation TherapySpinal Cord InjuriesHumansPostureProstheses and ImplantsQuality of Lifefunctional electrical stimulationneuroprosthesisSpinal cord injury

Identifiers

PMID32727296
PMCPMC9415059
OpenAlexW3045763777

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.