Evidence map›Paper›PMID 32727157›Full record

Trial reportNutrients2020

Urinary Metabolomic Profile of Preterm Infants Receiving Human Milk with Either Bovine or Donkey Milk-Based Fortifiers.

Marzia Giribaldi, Chiara Peila, Alessandra Coscia, Laura Cavallarin, Sara Antoniazzi, Sara Corbu, Giulia Maiocco, Stefano Sottemano, Francesco Cresi, Guido E Moro and 3 more

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Impact of Prematurity on Metabolic Maturation.Journal of proteome research · 2026
    Article
  5. Metabolomics can provide new insights into perinatal nutrition.Acta paediatrica (Oslo, Norway : 1992) · 2023
    Review
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Marzia GiribaldiCREA Research Centre for Engineering and Agro-Food Processing, 10135 Turin, Italy.ORCID 0000-0003-3507-7684
Chiara PeilaNeonatal Unit, University of Turin, City of Health and Science of Turin, 10126 Turin, Italy.ORCID 0000-0002-0075-5353
Alessandra CosciaNeonatal Unit, University of Turin, City of Health and Science of Turin, 10126 Turin, Italy.
Laura CavallarinInstitute of the Science of Food Production-National Research Council, 10095 Grugliasco (TO), Italy.ORCID 0000-0001-7006-1683
Sara AntoniazziInstitute of the Science of Food Production-National Research Council, 10095 Grugliasco (TO), Italy.
Sara CorbuDepartment of Chemical and Geological Sciences, Cittadella Universitaria, University of Cagliari, 09042 Cagliari, Italy.
Giulia MaioccoNeonatal Unit, University of Turin, City of Health and Science of Turin, 10126 Turin, Italy.ORCID 0000-0002-4889-1661
Stefano SottemanoNeonatal Unit, University of Turin, City of Health and Science of Turin, 10126 Turin, Italy.ORCID 0000-0002-1015-9862
Francesco CresiNeonatal Unit, University of Turin, City of Health and Science of Turin, 10126 Turin, Italy.ORCID 0000-0002-2139-6855
Guido E MoroItalian Association of Human Milk Banks (AIBLUD), 20126 Milan, Italy.ORCID 0000-0002-3429-3257
Enrico BertinoNeonatal Unit, University of Turin, City of Health and Science of Turin, 10126 Turin, Italy.
Vassilios FanosNeonatal Intensive Care Unit, Neonatal Pathology and Neonatal Section, Azienda University Polyclinic, University of Cagliari, 09124 Cagliari, Italy.
Flaminia Cesare MarincolaDepartment of Chemical and Geological Sciences, Cittadella Universitaria, University of Cagliari, 09042 Cagliari, Italy.ORCID 0000-0002-9695-5957

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fortification of human milk (HM) for preterm and very low-birth weight (VLBW) infants is a standard practice in most neonatal intensive care units. The optimal fortification strategy and the most suitable protein source for achieving better tolerance and growth rates for fortified infants are still being investigated. In a previous clinical trial, preterm and VLBW infants receiving supplementation of HM with experimental donkey milk-based fortifiers (D-HMF) showed decreased signs of feeding intolerance, including feeding interruptions, bilious gastric residuals and vomiting, with respect to infants receiving bovine milk-based fortifiers (B-HMF). In the present ancillary study, the urinary metabolome of infants fed B-HMF (

Indexed as

Food, FortifiedNutritional StatusAnimalsCarnitineCattleCholineEnteral NutritionEquidaeFemaleGalactoseHumansInfant, NewbornInfant, PrematureLeucineLysineMaleCarnitineCholineGalactoseLeucineLysine1H NMRadjustable fortificationbovine milkdonkey milkhuman milkpretermprotein fortifiersurinary metabolome

Identifiers

PMID32727157
PMCPMC7468788

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.