Evidence map›Paper›PMID 32727075›Full record

ArticleInternational journal of molecular sciences2020

Rapha Myr

Barbara Tomasello, Maria Domenica Di Mauro, Giuseppe Antonio Malfa, Rosaria Acquaviva, Fulvia Sinatra, Giorgia Spampinato, Samuele Laudani, Giusy Villaggio, Anna Bielak-Zmijewska, Wioleta Grabowska and 7 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 16 citations in OpenAlex.

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  6. Natural Compounds and Glutathione: Beyond Mere Antioxidants.Antioxidants (Basel, Switzerland) · 2023
    Review
  7. Wild Artichoke (Molecules (Basel, Switzerland) · 2023
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  10. Cells · 2022
    Article
  11. Article
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  13. The Antioxidant Activities ofAntioxidants (Basel, Switzerland) · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 2 countries.

Barbara TomaselloDepartment of Drug Science, Section of Biochemistry, University of Catania, Viale A. Doria 6, 95125 Catania, Italy.ORCID 0000-0001-6049-942X
Maria Domenica Di MauroDepartment of Drug Science, Section of Biochemistry, University of Catania, Viale A. Doria 6, 95125 Catania, Italy.
Giuseppe Antonio MalfaDepartment of Drug Science, Section of Biochemistry, University of Catania, Viale A. Doria 6, 95125 Catania, Italy.ORCID 0000-0002-6733-0587
Rosaria AcquavivaDepartment of Drug Science, Section of Biochemistry, University of Catania, Viale A. Doria 6, 95125 Catania, Italy.
Fulvia SinatraDepartment of Biomedical and Biotechnological Sciences, University of Catania, Via Santa Sofia 87, 95125 Catania, Italy.ORCID 0000-0003-0052-160X
Giorgia SpampinatoServices Center B.R.I.T. of the University of Catania, 95124 Catania, Italy.
Samuele LaudaniDepartment of Biomedical and Biotechnological Sciences, University of Catania, Via Santa Sofia 87, 95125 Catania, Italy.
Giusy VillaggioDepartment of Biomedical and Biotechnological Sciences, University of Catania, Via Santa Sofia 87, 95125 Catania, Italy.
Anna Bielak-ZmijewskaNencki Institute of Experimental Biology, Polish Academy of Sciences, 3 Pasteur St, 02-093 Warsaw, Poland: a.bielak@nencki.gov.pl (A.B.-Z.).ORCID 0000-0002-6330-4867
Wioleta GrabowskaNencki Institute of Experimental Biology, Polish Academy of Sciences, 3 Pasteur St, 02-093 Warsaw, Poland: a.bielak@nencki.gov.pl (A.B.-Z.).
Ignazio Alberto BarbagalloDepartment of Drug Science, Section of Biochemistry, University of Catania, Viale A. Doria 6, 95125 Catania, Italy.ORCID 0000-0002-7761-0662
Maria Teresa LiuzzoMedical Clinic of Clinical Allergology and Immunology, 97018 Scicli, Italy.
Elisabetta SbisàInstitute of Biomedical Technologies -National Research Council Bari, 70126 Bari, Italy.
Maria Grazia ForteDept. Prevention ASL BA-SIAN Metropolitan Area Bari, 70120 Bari, Italy.
Claudia Di GiacomoDepartment of Drug Science, Section of Biochemistry, University of Catania, Viale A. Doria 6, 95125 Catania, Italy.
Massimo BonucciAssociation Research Center for Integrative Oncology Treatments (ARTOI), 00165 Rome, Italy.
Marcella RenisDepartment of Drug Science, Section of Biochemistry, University of Catania, Viale A. Doria 6, 95125 Catania, Italy.
University of Catania · ITInstytut Biologii Doświadczalnej im. Marcelego Nenckiego · PLInstitute of Biomedical Technologies · ITItalian Association for Cancer Research · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Brain and other nervous system cancers are the 10th leading cause of death worldwide. Genome instability, cell cycle deregulation, epigenetic mechanisms, cytoarchitecture disassembly, redox homeostasis as well as apoptosis are involved in carcinogenesis. A diet rich in fruits and vegetables is inversely related with the risk of developing cancer. Several studies report that cruciferous vegetables exhibited antiproliferative effects due to the multi-pharmacological functions of their secondary metabolites such as isothiocyanate sulforaphane deriving from the enzymatic hydrolysis of glucosinolates. We treated human astrocytoma 1321N1 cells for 24 h with different concentrations (0.5, 1.25 and 2.5%

Indexed as

AnoikisAntineoplastic Combined Chemotherapy ProtocolsAstrocytomaCell Line, TumorDNA MethylationDNA, NeoplasmGlycoside HydrolasesHumansIsothiocyanatesNeoplasm ProteinsSirtuinsSulfoxidesDNA, NeoplasmGlycoside HydrolasesIsothiocyanatesNeoplasm ProteinsSirtuinssulforaphaneSulfoxidesthioglucosidaseanoikisapoptosisastrocytoma 1321N1 cellsbrain cancercell migrationcytoskeleton morphologyglobal DNA methylationmutated p53 R213Qmyrosinaseoxidative stresssirtuinssulforaphane

Identifiers

PMID32727075
PMCPMC7432334
OpenAlexW3044380286

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.