ArticleAnimals : an open access journal from MDPI2020
Morphological and Immunohistochemical Examination of Lymphoproliferative Lesions Caused by Marek's Disease Virus in Breeder Chickens.
Article in Animals : an open access journal from MDPI, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- The promise of pectic oligosaccharides as a novel sustainable additive in poultry production: A systematic review.Poultry science · 2026Pooled it
- Comparative pathological analysis of systemic atherosclerosis in two cases of Japanese bantams infected with Marek's disease virus.The Journal of veterinary medical science · 2026Article
- Article
- Survey of Animal Neoplastic Cases Diagnosed in Nigerian Veterinary Teaching Hospitals, 2000-2017.Veterinary sciences · 2024Article
- The First Record of an Aggressive Form of Ocular Tumour Enhanced by Marek's Disease Virus Infection in Layer Flock in Al-Najaf, Iraq.Veterinary medicine international · 2024Article
- Marek's disease in chicken farms from Northwest Ethiopia: gross pathology, virus isolation, and molecular characterization.Virology journal · 2023Article
- Economic and value chain analysis to support an investigation and risk mitigation efforts on Marek's disease in layers in the southern part of Thailand.Veterinary world · 2023Article
- Investigation of an Autochthonous Outbreak of Bovine Besnoitiosis in Northwestern Sicily.Pathogens (Basel, Switzerland) · 2022Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Marek's disease is widely controlled by vaccination programs; however, chickens are not totally protected, especially immediately after the vaccination when a strong challenge could interfere with the effectiveness of vaccination in the absence of proper biosecurity practice. This case report describes the occurrence of Marek's disease (MD) observed in a breeder chicken flock reared southeast of Sicily. MD outbreak occurred from 32 to 47 weeks with an increase in weekly mortality rate (+0.4-0.6%). Overall, mortality rate related to Marek's disease was about 6% at the end of the cycle. Carcasses of chickens found during the occurrence of disease underwent necropsy, and tissues were collected to confirm the infection. Gizzard, cecal tonsil, intestine, spleen and tumor mass were collected and analyzed from a carcass of one hen, 32 weeks old and apparently asymptomatic. Multiplex real-time PCR performed on spleen tissues detected the presence of MD virus pathogenic strain. Macroscopic and microscopic evaluation of the rest of the samples confirmed the neoplastic disease. Moreover, the immunophenotype of the tumor cells was identified as CD3 positive by immunohistochemical (IHC) staining. The vaccinated flock had become rapidly infected with the MD virus, which proves that the challenge of the MD virus was too strong in the rearing house at the beginning of the cycle, causing the outbreak.
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