ArticleNature2020
Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity.
Open access · bronzeAbstract read
In one paragraph
Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 689 papers.
0numbers the graph read from it
0cells of the map it votes in
689citing papers in PubMed
76.6field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
689 citing papers in PubMed, 1,222 citations in OpenAlex.
- Understanding protein ISGylation, a multifaceted posttranslational modification.Cell chemical biology · 2026Review
- Nsp3 Ubl1-orchestrated dephosphorylation of N protein promotes coronaviral subgenomic RNA synthesis.bioRxiv : the preprint server for biology · 2026Article
- Substrate-Selective Inhibition of the SARS-CoV-2 Papain-Like Protease: Inhibition of Hydrolysis of Human Over Viral Substrates.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Article
- Nanobodies targeting SARS-CoV-2 papain-like protease exert dual antiviral and anti-inflammatory effects.Journal of virology · 2026Article
- Pathway-specific mechanisms, therapeutic applications, and toxicodynamic profile of acriflavine in cancer: a comprehensive review.Naunyn-Schmiedeberg's archives of pharmacology · 2026Review
- Nitrile-Based Inhibitors Targeting both SARS-CoV‑2 Main Protease and Human Cathepsin L.ACS medicinal chemistry letters · 2026Article
- Antimicrobial peptides as computational candidates for SARS-CoV-2 papain-like protease inhibition.Scientific reports · 2026Article
- A fish-specific E3 ubiquitin ligase NHRE3 suppresses antiviral immunity by degrading ISG15 via ubiquitination.PLoS pathogens · 2026Article
- Target-Based Antiviral Drug Development Against Human Respiratory Viruses.Pathogens (Basel, Switzerland) · 2026Review
- A P3' methionine-to-phenylalanine substitution in the NSP6-7 substrate peptide alters SARS-CoV-2 MThe Journal of biological chemistry · 2026Article
- Host OTUB2 and viral PLpro stabilize NSP8 to promote SARS-CoV-2 replication.Virologica Sinica · 2026Article
- Cell-autonomous immunity as an integrated immune network against bacterial and viral pathogens.Nature microbiology · 2026Review
- Cleavage of TOM1 by the SARS-CoV-2 main protease NSP5 prevents autophagic degradation of viral envelope.Journal of virology · 2026Article
- Drug Repurposing as a Broad-Spectrum Strategy Against Coronaviruses: Frontiers in Mechanisms and Clinical Translation.Viruses · 2026Review
- Kinetic control of macrophage death by PTM-turnover crosstalk in infection and inflammation.Cell chemical biology · 2026Review
- Temporal Dynamics of Innate Immune Activation and Viral Interference During Sequential Co-Infection with Influenza A Virus and SARS-CoV-2: Molecular Mechanisms, Clinical Evidence, and Therapeutic Implications.International journal of molecular sciences · 2026Review
- Dysregulation of RIG-I activation by picornavirus 3A protein.Journal of virology · 2026Article
- Reprogramming innate immunity through viral interference: A double-edged strategy for enhancing and containing gene therapies.Molecular therapy. Nucleic acids · 2026Review
- Antibody repertoire associated with clinically diverse presentations of pediatric SARS-CoV-2 infection.Scientific reports · 2026Article
- 9-fluorenone-based synthetic sulfonamide compounds as dual inhibitors of SARS-CoV-2 Main-Protease and Papain-like Protease.Molecular diversity · 2026Article
629 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
22 authors at 6 institutions in 2 countries.
Donghyuk ShinInstitute of Biochemistry II, Faculty of Medicine, Goethe University, Frankfurt, Germany.ORCID http://orcid.org/0000-0002-8272-6133
Rukmini MukherjeeInstitute of Biochemistry II, Faculty of Medicine, Goethe University, Frankfurt, Germany.ORCID http://orcid.org/0000-0001-7955-6324
Diana GreweBuchmann Institute for Molecular Life Sciences, Goethe University, Frankfurt, Germany.ORCID http://orcid.org/0000-0002-4685-1383
Denisa BojkovaInstitute of Medical Virology, University Hospital Frankfurt, Frankfurt, Germany.
Kheewoong BaekDepartment of Molecular Machines and Signaling, Max Planck Institute of Biochemistry, Martinsried, Germany.ORCID http://orcid.org/0000-0002-6853-4936
Anshu BhattacharyaInstitute of Biochemistry II, Faculty of Medicine, Goethe University, Frankfurt, Germany.ORCID http://orcid.org/0000-0002-7383-3594
Laura SchulzDepartment of Theoretical Biophysics, Max Planck Institute of Biophysics, Frankfurt, Germany.ORCID http://orcid.org/0000-0002-2403-7129
Marek WideraInstitute of Medical Virology, University Hospital Frankfurt, Frankfurt, Germany.ORCID http://orcid.org/0000-0001-5417-9307
Ahmad Reza MehdipourDepartment of Theoretical Biophysics, Max Planck Institute of Biophysics, Frankfurt, Germany.ORCID http://orcid.org/0000-0002-0193-3334
Georg TascherInstitute of Biochemistry II, Faculty of Medicine, Goethe University, Frankfurt, Germany.ORCID http://orcid.org/0000-0002-5907-3947
Paul P GeurinkOncode Institute and Department of Chemical Immunology, Leiden University Medical Centre, Leiden, The Netherlands.ORCID http://orcid.org/0000-0003-1849-1111
Alexander WilhelmInstitute of Medical Virology, University Hospital Frankfurt, Frankfurt, Germany.
Gerbrand J van der Heden van NoortOncode Institute and Department of Chemical Immunology, Leiden University Medical Centre, Leiden, The Netherlands.ORCID http://orcid.org/0000-0001-5955-6431
Huib OvaaOncode Institute and Department of Chemical Immunology, Leiden University Medical Centre, Leiden, The Netherlands.ORCID http://orcid.org/0000-0002-0068-054X
Stefan MüllerInstitute of Biochemistry II, Faculty of Medicine, Goethe University, Frankfurt, Germany.ORCID http://orcid.org/0000-0002-8792-7700
Klaus-Peter KnobelochInstitute of Neuropathology, Faculty of Medicine, University of Freiburg, Freiburg, Germany.ORCID http://orcid.org/0000-0003-1587-1944
Krishnaraj RajalingamCell Biology Unit, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.ORCID http://orcid.org/0000-0002-4175-9633
Brenda A SchulmanDepartment of Molecular Machines and Signaling, Max Planck Institute of Biochemistry, Martinsried, Germany.ORCID http://orcid.org/0000-0002-3083-1126
Jindrich CinatlInstitute of Medical Virology, University Hospital Frankfurt, Frankfurt, Germany.ORCID http://orcid.org/0000-0002-6744-2087
Gerhard HummerDepartment of Theoretical Biophysics, Max Planck Institute of Biophysics, Frankfurt, Germany.ORCID http://orcid.org/0000-0001-7768-746X
Sandra CiesekInstitute of Medical Virology, University Hospital Frankfurt, Frankfurt, Germany.ORCID http://orcid.org/0000-0002-1802-7565
Ivan DikicInstitute of Biochemistry II, Faculty of Medicine, Goethe University, Frankfurt, Germany. dikic@biochem2.uni-frankfurt.de.ORCID http://orcid.org/0000-0001-8156-9511
Goethe University Frankfurt · DELeiden University · NLMax Planck Institute of Biochemistry · DEMax Planck Institute of Biophysics · DEJohannes Gutenberg University Mainz · DEUniversity of Freiburg · DE
Funding
European Research Council 742720European Research Council 789016
Abstract
The papain-like protease PLpro is an essential coronavirus enzyme that is required for processing viral polyproteins to generate a functional replicase complex and enable viral spread
Indexed as
Immunity, InnateAnimalsCoronavirus Papain-Like ProteasesCOVID-19COVID-19 Drug TreatmentCytokinesDeubiquitinating EnzymesHumansInterferon Regulatory Factor-3InterferonsMiceModels, MolecularMolecular Dynamics SimulationNF-kappa BProtein BindingSARS-CoV-2Coronavirus Papain-Like ProteasesCytokinesDeubiquitinating EnzymesG1p2 protein, mouseInterferon Regulatory Factor-3InterferonsIRF3 protein, humanISG15 protein, humanNF-kappa BUbiquitins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.