Evidence map›Paper›PMID 32726634›Full record

ArticleCell reports2020

Calcium-Permeable AMPA Receptors Promote Endocannabinoid Signaling at Parvalbumin Interneuron Synapses in the Nucleus Accumbens Core.

Kevin M Manz, Dipanwita Ghose, Brandon D Turner, Anne Taylor, Jennifer Becker, Carrie A Grueter, Brad A Grueter

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 32 citations in OpenAlex.

  1. Review
  2. Article
  3. Role and mechanisms of interneurons in chronic pain and pain-induced cognitive impairment.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025
    Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. Nano-organization of synaptic calcium signaling.Biochemical Society transactions · 2024
    Review
  9. Article
  10. Article
  11. Role of mesolimbic cannabinoid receptor 1 in stress-driven increases in cocaine self-administration in male rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023
    Article
  12. Article
  13. Article
  14. Endocannabinoids at the synapse and beyond: implications for neuropsychiatric disease pathophysiology and treatment.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023
    Review
  15. Article
  16. Striatal Indirect Pathway Dysfunction Underlies Motor Deficits in a Mouse Model of Paroxysmal Dyskinesia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
  17. Cocaine restricts nucleus accumbens feedforward drive through a monoamine-independent mechanism.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022
    Article
  18. Review
  19. Kappa opioid receptor modulation of excitatory drive onto nucleus accumbens fast-spiking interneurons.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Kevin M ManzMedical Scientist Training Program, Vanderbilt University, Nashville, TN 37232, USA; Neuroscience Graduate Program, Vanderbilt University, Nashville, TN 37232, USA; Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Dipanwita GhoseDepartment of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Brandon D TurnerNeuroscience Graduate Program, Vanderbilt University, Nashville, TN 37232, USA.
Anne TaylorNeuroscience Graduate Program, Vanderbilt University, Nashville, TN 37232, USA.
Jennifer BeckerDepartment of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Carrie A GrueterVanderbilt Brain Institute, Vanderbilt University, Nashville, TN 37232, USA; Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Brad A GrueterVanderbilt Brain Institute, Vanderbilt University, Nashville, TN 37232, USA; Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Vanderbilt Center for Addiction Research, Vanderbilt University, Nashville, TN 37232, USA; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232, USA. Electronic address: brad.grueter@vumc.org.
Vanderbilt University · USVanderbilt University Medical Center · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007347 · NIGMS · VANDERBILT UNIVERSITY · PI WILLIAMS, CHRISTOPHER S. · 1985 to 2023
$26.3M
Overall: Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at VanderbiltP50HD103537 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Jeffrey L Neul · 2020 to 2026
$10.3M
Medical Scientist Training ProgramT32GM152284 · NIGMS · VANDERBILT UNIVERSITY · PI Christopher S. Williams · 2024 to 2026
$4.8M
Parvalbumin interneurons regulate nucleus accumbens synapses and behaviorR01DA040630 · NIDA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GRUETER, BRAD ALAN · 2016 to 2025
$4.5M
TIPS: Training in Perioperative ScienceT32GM108554 · NIGMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Eric J Delpire · 2014 to 2026
$3.7M
Photoperiodic Programming of Monoamine Brain CircuitsR01MH130537 · NIMH · VANDERBILT UNIVERSITY · PI Brad Alan Grueter, DOUGLAS G MCMAHON · 2023 to 2026
$2.6M
Synaptic Mechanisms of Addiction-Related Behaviors in the Nucleus AccumbensR00DA031699 · NIDA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GRUETER, BRAD ALAN · 2013 to 2015
$743k
NICHD NIH HHS P50 HD103537NIDA NIH HHS R00 DA031699NIDA NIH HHS R01 DA040630NIGMS NIH HHS T32 GM007347NIGMS NIH HHS T32 GM108554NIGMS NIH HHS T32 GM152284NIMH NIH HHS R01 MH130537
6 · The paper itself

Abstract

Synaptic plasticity is a key mechanism of learning and memory. Synaptic plasticity mechanisms within the nucleus accumbens (NAc) mediate differential behavioral adaptations. Feedforward inhibition in the NAc occurs when glutamatergic afferents onto medium spiny neurons (MSNs) collateralize onto fast-spiking parvalbumin (PV)-expressing interneurons (PV-INs), which exert GABAergic control over MSN action potential generation. Here, we find that feedforward glutamatergic synapses onto PV-INs in the NAc core selectively express Ca

Indexed as

Action PotentialsAnimalsCalciumEndocannabinoidsGlutamic AcidInterneuronsLong-Term Synaptic DepressionMaleMiceMice, Inbred C57BLNeuronal PlasticityNeuronsNucleus AccumbensParvalbuminsReceptors, AMPAReceptors, Calcium-SensingCalciumEndocannabinoidsGlutamic AcidParvalbuminsReceptors, AMPAReceptors, Calcium-SensingCB(1) receptorCP-AMPA receptorsendocannabinoidsfeedforward inhibitionnucleus accumbensplasticity

Identifiers

PMID32726634
PMCPMC7422922
OpenAlexW3045552511

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.