ArticleCell reports2020
NMDAR-Dependent Emergence of Behavioral Representation in Primary Visual Cortex.
Article in Cell reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- SST interneurons facilitate dendritic calcium signaling via tonic activation of α5-GABA receptors.Neuron · 2026Article
- Visual experience drives functional reorganization of cortical GABAergic circuits.bioRxiv : the preprint server for biology · 2026Article
- Sexually dimorphic plasticity of PV inhibition in sensory neocortex during learning.Scientific reports · 2026Article
- Neocortical somatostatin neuron diversity in cognition and learning.Trends in neurosciences · 2025Review
- Structure-function relationships across scales: implications for atlases.Frontiers in neuroscience · 2025Article
- Transient enhancement of stimulus-evoked activity in neocortex during sensory learning.Learning & memory (Cold Spring Harbor, N.Y.) · 2024Article
- Rapid fluctuations in functional connectivity of cortical networks encode spontaneous behavior.Nature neuroscience · 2024Article
- Neurons in the primary visual cortex of freely moving rats encode both sensory and non-sensory task variables.PLoS biology · 2023Article
- Aberrant maturation and connectivity of prefrontal cortex in schizophrenia-contribution of NMDA receptor development and hypofunction.Molecular psychiatry · 2022Review
- Stimulus-dependent representational drift in primary visual cortex.Nature communications · 2021Article
- Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Although neocortical sensory areas are generally thought to faithfully represent external stimuli, cortical networks exhibit considerable functional plasticity, allowing them to modify their output to reflect ongoing behavioral demands. We apply longitudinal 2-photon imaging of activity in the primary visual cortex (V1) of mice learning a conditioned eyeblink task to investigate the dynamic representations of task-relevant information. We find that, although all V1 neurons robustly and stably encode visual input, pyramidal cells and parvalbumin-expressing interneurons exhibit experience-dependent emergence of accurate behavioral representations during learning. The functional plasticity driving performance-predictive activity requires cell-autonomous expression of NMDA-type glutamate receptors. Our findings demonstrate that accurate encoding of behavioral output is not inherent to V1 but develops during learning to support visual task performance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.