Evidence map›Paper›PMID 32726628›Full record

ArticleCell reports2020

Dissecting Murine Muscle Stem Cell Aging through Regeneration Using Integrative Genomic Analysis.

Anna Shcherbina, Jacqueline Larouche, Paula Fraczek, Benjamin A Yang, Lemuel A Brown, James F Markworth, Carolina H Chung, Mehwish Khaliq, Kanishka de Silva, Jeongmoon J Choi and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 78 citations in OpenAlex.

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  17. Cellular mechanotransduction of human osteoblasts in microgravity.bioRxiv : the preprint server for biology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Anna ShcherbinaDepartment of Biomedical Informatics, Stanford University, Palo Alto, CA 94305, USA.
Jacqueline LaroucheDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA; Biointerfaces Institute, University of Michigan, Ann Arbor, MI 48109, USA.
Paula FraczekDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA; Biointerfaces Institute, University of Michigan, Ann Arbor, MI 48109, USA.
Benjamin A YangDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA; Biointerfaces Institute, University of Michigan, Ann Arbor, MI 48109, USA.
Lemuel A BrownDepartment of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.
James F MarkworthDepartment of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.
Carolina H ChungDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
Mehwish KhaliqDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA; Program in Cancer Biology, University of Michigan, Ann Arbor, MI 48109, USA.
Kanishka de SilvaDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA; Biointerfaces Institute, University of Michigan, Ann Arbor, MI 48109, USA.
Jeongmoon J ChoiParker H. Petit Institute of Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332, USA; School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332, USA; Wallace Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Mohammad Fallahi-SichaniDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA; Department of Biomedical Engineering, University of Virginia, Charlottesville, VA 22903, USA.
Sriram ChandrasekaranDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
Young C JangParker H. Petit Institute of Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332, USA; School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332, USA; Wallace Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Susan V BrooksDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.
Carlos A AguilarDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA; Biointerfaces Institute, University of Michigan, Ann Arbor, MI 48109, USA; Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: caguilar@umich.edu.
University of Michigan · USGeorgia Institute of Technology · USStanford University · US

Funding

Research Education CoreP30AG024824 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Neil Alexander · 2004 to 2026
$29.2M
POSTDOCTORAL TRAINING IN MEDICAL INFORMATION SCIENCEST15LM007033 · NLM · STANFORD UNIVERSITY · PI SYLVIA KATINA PLEVRITIS · 1985 to 2026
$25.5M
PROJECT 3: Neuromuscular redox homeostasis in mice lacking SOD1 and aging wild type mice subcontract at University of LiverpoolP01AG051442 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI JACKSON, MALCOLM JOSEPH · 2016 to 2020
$8.9M
Structure, Composition, & Histology Core - Core BP30AR069620 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KARL J JEPSEN · 2016 to 2026
$8.4M
Training Program in Tumor MicroenvironmentT32CA009676 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Maria G Castro, Analisa Virginia DiFeo · 1992 to 2026
$7.3M
Decoding the Logic of Cellular Signaling Through the Integration of Dynamic, Single-Cell and Multiplexed MethodsR35GM133404 · NIGMS · UNIVERSITY OF VIRGINIA · PI Mohammad Fallahi-Sichani · 2019 to 2026
$3.1M
NCI NIH HHS T32 CA009676NIAMS NIH HHS P30 AR069620NIA NIH HHS P01 AG051442NIA NIH HHS P30 AG024824NIGMS NIH HHS R35 GM133404NLM NIH HHS T15 LM007033
6 · The paper itself

Abstract

During aging, there is a progressive loss of volume and function in skeletal muscle that impacts mobility and quality of life. The repair of skeletal muscle is regulated by tissue-resident stem cells called satellite cells (or muscle stem cells [MuSCs]), but in aging, MuSCs decrease in numbers and regenerative capacity. The transcriptional networks and epigenetic changes that confer diminished regenerative function in MuSCs as a result of natural aging are only partially understood. Herein, we use an integrative genomics approach to profile MuSCs from young and aged animals before and after injury. Integration of these datasets reveals aging impacts multiple regulatory changes through significant differences in gene expression, metabolic flux, chromatin accessibility, and patterns of transcription factor (TF) binding activities. Collectively, these datasets facilitate a deeper understanding of the regulation tissue-resident stem cells use during aging and healing.

Indexed as

AgingAnimalsCell LineCellular SenescenceFemaleGenomicsMiceMice, Inbred C57BLMuscle CellsMuscle, SkeletalMyoblastsRegenerationSatellite Cells, Skeletal MuscleStem Cells1-carbon metabolismDdit3expressionheterochromatinMyoDregenerationtranscription factor bindingvitamin A

Identifiers

PMID32726628
PMCPMC8025697
OpenAlexW3045623544

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.