ArticleCell reports2020
Active Lysogeny in Listeria Monocytogenes Is a Bacteria-Phage Adaptive Response in the Mammalian Environment.
Article in Cell reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 53 citations in OpenAlex.
- Revisiting the life cycle of temperate phages.Nature reviews. Microbiology · 2026Review
- The phage Φ13-encoded transcriptional regulator Ltr controls phage assembly in Staphylococcus aureus.Virology journal · 2026Article
- Gut Microbiota, Diet and Lipid Metabolism in Adolescents with NAFLD and Their Role in Preventive Strategies.International journal of molecular sciences · 2026Review
- Conditional activation of Cas13 enforces lysogeny in a native type VI-A CRISPR host.Nature microbiology · 2026Article
- Prophage: agent provocateur?Archives of microbiology · 2026Review
- Glucose-induced active lysogeny of prophage ΦSa3XN promotes Staphylococcus aureus virulence.Virology journal · 2025Article
- Genomic Relationship BetweenGenes · 2025Article
- GWAS Study Applied to Phenotypically Slow Growth Strains ofMicroorganisms · 2025Article
- A prophage competition element protects Salmonella from lysis.Cell host & microbe · 2024Article
- Specialized Listeria monocytogenes produce tailocins to provide a population-level competitive growth advantage.Nature microbiology · 2024Article
- Exploring the transcriptional landscape of phage-host interactions using novel high-throughput approaches.Current opinion in microbiology · 2024Review
- Gut microbiome and NAFLD: impact and therapeutic potential.Frontiers in microbiology · 2024Review
- Meeting report 'Microbiology 2023: from single cell to microbiome and host', an international interacademy conference in Würzburg.microLife · 2024Article
- Chromosome folding and prophage activation reveal specific genomic architecture for intestinal bacteria.Microbiome · 2023Article
- Viruses Regulate Microbial Community Assembly Together with Environmental Factors in Acid Mine Drainage.Applied and environmental microbiology · 2023Article
- The Role of Temperate Phages in Bacterial Pathogenicity.Microorganisms · 2023Review
- Inactivation ofFrontiers in microbiology · 2023Article
- Live-cell imaging reveals single-cell and population-level infection strategies ofFrontiers in immunology · 2023Article
- Influence ofViruses · 2022Article
- A dual-function phage regulator controls the response of cohabiting phage elements via regulation of the bacterial SOS response.Cell reports · 2022Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Some Listeria monocytogenes (Lm) strains harbor a prophage within the comK gene, which renders it inactive. During Lm infection of macrophage cells, the prophage turns into a molecular switch, promoting comK gene expression and therefore Lm intracellular growth. During this process, the prophage does not produce infective phages or cause bacterial lysis, suggesting it has acquired an adaptive behavior suited to the pathogenic lifestyle of its host. In this study, we demonstrate that this non-classical phage behavior, named active lysogeny, relies on a transcriptional response that is specific to the intracellular niche. While the prophage undergoes lytic induction, the process is arrested midway, preventing the transcription of the late genes. Further, we demonstrate key phage factors, such as LlgA transcription regulator and a DNA replicase, that support the phage adaptive behavior. This study provides molecular insights into the adaptation of phages to their pathogenic hosts, uncovering unusual cooperative interactions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.