Evidence map›Paper›PMID 32726500›Full record

ArticleAngewandte Chemie (International ed. in English)2020

A Frequency-Selective pH-Responsive paraCEST Agent.

S James Ratnakar, Sara Chirayil, Alexander M Funk, Shanrong Zhang, João F Queiró, Carlos F G C Geraldes, Zoltan Kovacs, A Dean Sherry

Abstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

S James RatnakarAdvanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Sara ChirayilAdvanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Alexander M FunkAdvanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Shanrong ZhangAdvanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, USA.
João F QueiróCMUC, Department of Mathematics, University of Coimbra, Coimbra, Portugal.
Carlos F G C GeraldesDepartment of Life Sciences and Coimbra Chemistry Center, University of Coimbra, Coimbra, Portugal.
Zoltan KovacsAdvanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, USA.
A Dean SherryAdvanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0001-7150-8301

Funding

TR&D 3: Imaging Carbohydrate MetabolismP41EB015908 · NIBIB · UT SOUTHWESTERN MEDICAL CENTER · PI MALLOY, CRAIG R · 2012 to 2021
$10.9M
PARACEST AGENTS FOR MOLECULAR IMAGING OF CANCER BY MRIR01CA115531 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI SHERRY, DEAN · 2005 to 2021
$4.2M
Multi-component Technology Intervention for African American Emerging Adults with Asthma.R01HL133506 · NHLBI · WAYNE STATE UNIVERSITY · PI MACDONELL, KAREN · 2016 to 2020
$3.1M
Avance III HD (AV3) ConsoleS10OD023552 · OD · UT SOUTHWESTERN MEDICAL CENTER · PI TAKAHASHI, MASAYA · 2017 to 2017
$600k
NCI NIH HHS R01 CA115531NHLBI NIH HHS R01 HL133506NIBIB NIH HHS EB-02584NIBIB NIH HHS P41 EB015908NIH HHS S10 OD023552U.S. Department of Health and Human Services CA-115531
6 · The paper itself

Abstract

Paramagnetic chemical exchange saturation transfer (paraCEST) agents are well-suited for imaging tissue pH because the basis of CEST, chemical exchange, is inherently sensitive to pH. Several previous pH-sensitive paraCEST agents were based on an exchanging Ln

Indexed as

AnimalsContrast MediaCoordination ComplexesHydrogen-Ion ConcentrationLanthanoid Series ElementsLigandsLuminescent AgentsMagnetic Resonance ImagingMiceMice, Inbred C57BLMolecular StructureContrast MediaCoordination ComplexesLanthanoid Series ElementsLigandsLuminescent Agentscontrast agentsimaging agentslanthanide complexesparaCESTpH sensing

Identifiers

PMID32726500
PMCPMC7719596

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.