ArticleThe Journal of clinical endocrinology and metabolism2020
Expression of the Insulin-like Growth Factor System in First- and Second-Trimester Human Embryonic and Fetal Gonads.
Article in The Journal of clinical endocrinology and metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04613583 (Normal Development of the Human Fetus and the Influences and Mechanisms by Which That Development Occurs and is Perturbed), which is not on this map. Cited by 9 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Normal Development of the Human Fetus and the Influences and Mechanisms by Which That Development Occurs and is Perturbed
Who cites it
9 citing papers in PubMed, 12 citations in OpenAlex.
- The Liver-Testis Axis: Molecular Mechanisms and Clinical Implications.International journal of molecular sciences · 2026Review
- The emergence of multiple testicular cell lineages in human stem cell-derived testis-like organoids.Development (Cambridge, England) · 2026Article
- Epigenetic regulation in female reproduction: the impact of m6A on maternal-fetal health.Cell death discovery · 2025Review
- Expression of genes and enzymes involved in ovarian steroidogenesis in relation to human follicular development.Frontiers in endocrinology · 2023Article
- Concentrations of oocyte secreted GDF9 and BMP15 decrease with MII transition during human IVM.Reproductive biology and endocrinology : RB&E · 2022Article
- Intrafollicular Concentrations of the Oocyte-secreted Factors GDF9 and BMP15 Vary Inversely in Polycystic Ovaries.The Journal of clinical endocrinology and metabolism · 2022Article
- Genetic Background of Fetal Growth Restriction.International journal of molecular sciences · 2021Review
- Effects of Er:YAG laser treatment on re-vascularization and follicle survival in frozen/thawed human ovarian cortex transplanted to immunodeficient mice.Journal of assisted reproduction and genetics · 2021Article
- Consequences ofFrontiers in endocrinology · 2020Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
Abstract
contextInsulin-like growth factor (IGF) signaling is crucial for sex differentiation and development of Leydig and Sertoli cells in fetal mice testes. No such information is available for human embryonic and fetal testes and ovaries.
objectiveTo investigate presence and activity of the IGF signaling system during human embryonic and fetal ovarian and testicular development.
designHuman embryonic and fetal gonads were obtained following legal terminations of pregnancies. Gene expression was assessed by microarray and qPCR transcript analyses. Proteins of the IGF system components were detected with immunohistochemistry and immunofluorescence analyses. Specimens were included from 2010 to 2017.
settingUniversity Hospital. PATIENTS/
participantsOvaries and testes from a total of 124 human embryos and fetuses aged 5 to 17 postconception weeks were obtained from healthy women aged 16 to 47 years resident in Denmark or Scotland.
main outcome measuresGene expression analysis using microarray was performed in 46 specimens and qPCR analysis in 56 specimens, both sexes included. Protein analysis included 22 specimens (11 ovaries, 11 testes).
resultsIGF system members were detected in embryonic and fetal testes and ovaries, both at gene transcript and protein level. A higher expression of IGF regulators was detected in testes than ovaries, with a preferred localization to Leydig cells.
conclusionsThese data indicate that the IGF system is active during very early gestation, when it may have a regulatory role in Leydig cells.
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Registered trials
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