Evidence map›Paper›PMID 32726331›Full record

ArticlePloS one2020

Innate immune responses to malaria-infected erythrocytes in pregnant women: Effects of gravidity, malaria infection, and geographic location.

Marzieh Jabbarzare, Madi Njie, Anthony Jaworowski, Alexandra J Umbers, Maria Ome-Kaius, Wina Hasang, Louise M Randall, Bill Kalionis, Stephen J Rogerson

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 88% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Marzieh JabbarzareDepartment of Medicine at the Doherty Institute, University of Melbourne, Melbourne, Australia.ORCID 0000-0001-7369-9463
Madi NjieDepartment of Medicine at the Doherty Institute, University of Melbourne, Melbourne, Australia.
Anthony JaworowskiSchool of Health and Biomedical Sciences, RMIT University, Melbourne, Victoria, Australia.
Alexandra J UmbersVector Borne Diseases Unit, Papua New Guinea Institute of Medical Research, Madang, Papua New Guinea.
Maria Ome-KaiusVector Borne Diseases Unit, Papua New Guinea Institute of Medical Research, Madang, Papua New Guinea.
Wina HasangDepartment of Medicine at the Doherty Institute, University of Melbourne, Melbourne, Australia.
Louise M RandallDepartment of Medicine at the Doherty Institute, University of Melbourne, Melbourne, Australia.
Bill KalionisDepartment of Maternal-Fetal Medicine, Pregnancy Research Centre, Royal Women's Hospital Department of Obstetrics and Gynaecology, University of Melbourne, Parkville, Australia.
Stephen J RogersonDepartment of Medicine at the Doherty Institute, University of Melbourne, Melbourne, Australia.
The University of Melbourne · AUPapua New Guinea Institute of Medical Research · PGRMIT University · AURoyal Women's Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMalaria in pregnancy causes maternal, fetal and neonatal morbidity and mortality, and maternal innate immune responses are implicated in pathogenesis of these complications. The effects of malaria exposure and obstetric and demographic factors on the early maternal immune response are poorly understood.

methodsPeripheral blood mononuclear cell responses to Plasmodium falciparum-infected erythrocytes and phytohemagglutinin were compared between pregnant women from Papua New Guinea (malaria-exposed) with and without current malaria infection and from Australia (unexposed). Elicited levels of inflammatory cytokines at 48 h and 24 h (interferon γ, IFN-γ only) and the cellular sources of IFN-γ were analysed.

resultsAmong Papua New Guinean women, microscopic malaria at enrolment did not alter peripheral blood mononuclear cell responses. Compared to samples from Australia, cells from Papua New Guinean women secreted more inflammatory cytokines tumor necrosis factor-α, interleukin 1β, interleukin 6 and IFN-γ; p<0.001 for all assays, and more natural killer cells produced IFN-γ in response to infected erythrocytes and phytohemagglutinin. In both populations, cytokine responses were not affected by gravidity, except that in the Papua New Guinean cohort multigravid women had higher IFN-γ secretion at 24 h (p = 0.029) and an increased proportion of IFN-γ+ Vδ2 γδ T cells (p = 0.003). Cytokine levels elicited by a pregnancy malaria-specific CSA binding parasite line, CS2, were broadly similar to those elicited by CD36-binding line P6A1.

conclusionsGeographic location and, to some extent, gravidity influence maternal innate immunity to malaria.

Indexed as

AdolescentAdultAustraliaCD36 AntigensErythrocytesFemaleGravidityHumansImmunity, InnateInterferon-gammaInterleukin-6Killer Cells, NaturalLeukocytes, MononuclearMalaria, FalciparumMiddle AgedPapua New GuineaCD36 AntigensInterferon-gammaInterleukin-6

Identifiers

PMID32726331
PMCPMC7390391
OpenAlexW3045681859

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.