ArticlePloS one2020
The effect of a severe psychiatric illness on colorectal cancer treatment and survival: A population-based retrospective cohort study.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Colorectal cancer mortality in persons with severe mental illness: a scoping review with meta-analyses of observational studies.Acta oncologica (Stockholm, Sweden) · 2025Pooled it
- Strengthening the delivery of integrated physical health care for adults experiencing serious mental illness: a scoping review of interventions in mental health settings.Frontiers in health services · 2025Pooled it
- Colorectal cancer treatment in people with severe mental illness: a systematic review and meta-analysis.Epidemiology and psychiatric sciences · 2022Pooled it
- How equity in cancer services has been defined and measured, and why it matters: a scoping review of Universal Health Coverage systems.Global health action · 2026Article
- Assessing the Needs of Community Mental Health Service Users with Chronic Physical Health Conditions: A Cross-Sectional Study.Community mental health journal · 2026Article
- Article
- Mortality following cancer diagnosis among people with non-affective psychoses: mediation by stage at diagnosis and time to treatment initiation.Social psychiatry and psychiatric epidemiology · 2026Article
- Impact of Schizophrenia Spectrum Disorders on the Receipt of Invasive and Systemic Therapy for Colorectal Cancer: A Nationwide Multicenter Retrospective Cohort Study in Japan.Acta psychiatrica Scandinavica · 2026Article
- Facilitating equity-oriented cancer care in organizations delivering cancer services: insights from a qualitative study.Frontiers in oncology · 2026Article
- Mental illness and non-metastatic colorectal cancer treatment and survival, a nationwide study of almost 70,000 patients.Acta oncologica (Stockholm, Sweden) · 2025Article
- Inequities in the Time to Colon Cancer Diagnosis Among Individuals With Severe Psychiatric Illness.Cancer medicine · 2025Article
- Treatment and Mortality Following Cancer Diagnosis Among People With Non-affective Psychotic Disorders in Ontario, Canada: A Retrospective Cohort Study.Schizophrenia bulletin · 2024Article
- Rates of colorectal cancer diagnosis and mortality in people with severe mental illness: results from Australia's National Bowel Cancer Screening Programme.Epidemiology and psychiatric sciences · 2024Article
- Application of fecal immunochemical test in colorectal cancer screening: A community-based, cross-sectional study in average-risk individuals in Hainan.World journal of gastrointestinal oncology · 2024Article
- Secondary Stroke Prevention in People With Schizophrenia.Journal of the American Heart Association · 2024Article
- The double burden of severe mental illness and cancer: a population-based study on colorectal cancer care pathways from screening to end-of-life care.Epidemiology and psychiatric sciences · 2024Article
- Dissecting the novel abilities of aripiprazole: The generation of anti-colorectal cancer effects by targeting GActa pharmaceutica Sinica. B · 2023Article
- Health and healthcare equity within the Canadian cancer care sector: a rapid scoping review.International journal for equity in health · 2023Article
- Disparities in the medical expenditures of patients with cancer and concomitant mental disorder: analyzing the effects of diagnosis sequence order.BMC health services research · 2023Article
- Breast Cancer Care Pathways for Women with Preexisting Severe Mental Disorders: Evidence of Disparities in France?Journal of clinical medicine · 2023Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
objectivesTo identify inequalities in cancer survival rates for patients with a history of severe psychiatric illness (SPI) compared to those with no history of mental illness and explore differences in the provision of recommended cancer treatment as a potential explanation.
designPopulation-based retrospective cohort study using linked cancer registry and administrative data at ICES.
settingThe universal healthcare system in Ontario, Canada.
participantsColorectal cancer (CRC) patients diagnosed between April 1st, 2007 and December 31st, 2012. SPI history (schizophrenia, schizoaffective disorders, other psychotic disorders, bipolar disorders or major depressive disorders) was determined using hospitalization, emergency department, and psychiatrist visit data and categorized as 'no history of mental illness, 'outpatient SPI history', and 'inpatient SPI history'.
main outcome measuresCancer-specific survival, non-receipt of surgical resection, and non-receipt of adjuvant chemotherapy or radiation.
results24,507 CRC patients were included; 482 (2.0%) had an outpatient SPI history and 258 (1.0%) had an inpatient SPI history. Individuals with an SPI history had significantly lower survival rates and were significantly less likely to receive guideline recommended treatment than CRC patients with no history of mental illness. The adjusted HR for cancer-specific death was 1.69 times higher for individuals with an inpatient SPI (95% CI 1.36-2.09) and 1.24 times higher for individuals with an outpatient SPI history (95% CI 1.04-1.48). Stage II and III CRC patients with an inpatient SPI history were 2.15 times less likely (95% CI 1.07-4.33) to receive potentially curative surgical resection and 2.07 times less likely (95% CI 1.72-2.50) to receive adjuvant radiation or chemotherapy. These findings were consistent across multiple sensitivity analyses.
conclusionsIndividuals with an SPI history experience inequalities in colorectal cancer care and survival within a universal healthcare system. Increasing advocacy and the availability of resources to support individuals with an SPI within the cancer system are warranted to reduce the potential for unnecessary harm.
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