Evidence map›Paper›PMID 32726189›Full record

ArticleStatistical methods in medical research2021

Functional survival forests for multivariate longitudinal outcomes: Dynamic prediction of Alzheimer's disease progression.

Jeffrey Lin, Kan Li, Sheng Luo

Abstract read
In one paragraph

Article in Statistical methods in medical research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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  9. tdCoxSNN: Time-dependent Cox survival neural network for continuous-time dynamic prediction.Journal of the Royal Statistical Society. Series C, Applied statistics · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jeffrey LinDepartment of Biostatistics, University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID 0000-0003-0180-0117
Kan LiMerck Research Laboratory, Merck & Co., North Wales, PA, USA.
Sheng LuoDepartment of Biostatistics and Bioinformatics, Duke University, Durham, NC, USA * for the "Alzheimer's Neuroimaging Initative" per ADNI Data Use Agreement.ORCID 0000-0003-4214-5809

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
Integrative modeling and dynamic prediction of Alzheimer's diseaseR01AG064803 · NIA · DUKE UNIVERSITY · PI LUO, SHENG · 2020 to 2024
$2.3M
Integrative modeling and dynamic prediction of Alzheimer's diseaseR56AG064803 · NIA · DUKE UNIVERSITY · PI LUO, SHENG · 2019 to 2019
$483k
NIA NIH HHS R01 AG064803NIA NIH HHS R56 AG064803NIA NIH HHS U01 AG024904
6 · The paper itself

Abstract

The random survival forest (RSF) is a non-parametric alternative to the Cox proportional hazards model in modeling time-to-event data. In this article, we developed a modeling framework to incorporate multivariate longitudinal data in the model building process to enhance the predictive performance of RSF. To extract the essential features of the multivariate longitudinal outcomes, two methods were adopted and compared: multivariate functional principal component analysis and multivariate fast covariance estimation for sparse functional data. These resulting features, which capture the trajectories of the multiple longitudinal outcomes, are then included as time-independent predictors in the subsequent RSF model. This non-parametric modeling framework, denoted as functional survival forests, is better at capturing the various trends in both the longitudinal outcomes and the survival model which may be difficult to model using only parametric approaches. These advantages are demonstrated through simulations and applications to the Alzheimer's Disease Neuroimaging Initiative.

Indexed as

Alzheimer DiseaseDisease ProgressionHumansNeuroimagingProportional Hazards Modelsarea under the curveBrier scoreFunctional data analysisjoint modelpersonalized predictionsurvival ensembles

Identifiers

PMID32726189
PMCPMC7855476

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.