ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2020
A murine model of pediatric inflammatory bowel disease causes microbiota-gut-brain axis deficits in adulthood.
Article in American journal of physiology. Gastrointestinal and liver physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 49 citations in OpenAlex.
- Host-microbiome interactions and enteric pathogen infections-from early-life to long-term impacts on gut-brain communication.Journal of applied microbiology · 2026Review
- Neonatal enteric infection disrupts the microbiota-gut-brain axis through pattern recognition receptors and altered neuroimmune signaling.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- A joint transdisciplinary approach for paediatric inflammatory bowel disease: Integrating nursing, dietetic and psychological support.JPGN reports · 2026Article
- Early-life gastrointestinal inflammation and the developing brain: Unravelling the pathways to long-term cognitive dysfunction.World journal of clinical pediatrics · 2026Review
- The Gut Microbiome in Early Ontogeny: Implications for Brain and Immune System Development.Journal of developmental biology · 2026Review
- Microbiome Gut-Brain-Axis: Impact on Brain Development and Mental Health.Molecular neurobiology · 2025Review
- From gut inflammation to psychiatric comorbidity: mechanisms and therapies for anxiety and depression in inflammatory bowel disease.Journal of neuroinflammation · 2025Review
- Review
- CU06-1004 inhibits the progression of chronic colitis and colitis-associated colorectal cancer by suppressing inflammation.Frontiers in pharmacology · 2025Article
- Experimentally induced colitis impacts myelin development and home-cage behavior in young pigs regardless of supplementation with oral gamma-cyclodextrin-encapsulated tributyrin.Frontiers in neuroscience · 2025Article
- Motor, mood, and memory impairments persist during remission periods in chronic colitis and are influenced by neuroinflammation and sex.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024Article
- Necrotizing Enterocolitis and Neurodevelopmental Impairments: Microbiome, Gut, and Brain Entanglements.Biomolecules · 2024Review
- Milk andAmerican journal of physiology. Gastrointestinal and liver physiology · 2024Article
- The Potential Impact of the Gut Microbiota on Neonatal Brain Development and Adverse Health Outcomes.Children (Basel, Switzerland) · 2024Review
- Psychiatric Comorbidities of Inflammatory Bowel Disease: It Is a Matter of Microglia's Gut Feeling.Cells · 2024Review
- Unraveling the fatigue puzzle: insights into the pathogenesis and management of IBD-related fatigue including the role of the gut-brain axis.Frontiers in medicine · 2024Review
- Article
- Gut-brain axis: does intestinal inflammation affect hippocampal neurogenesis and medulloblastoma development?Neural regeneration research · 2023Article
- Role of the microbiota-gut-brain axis in postacute COVID syndrome.American journal of physiology. Gastrointestinal and liver physiology · 2023Review
- Gut-Brain Axis: Insights from Hippocampal Neurogenesis and Brain Tumor Development in a Mouse Model of Experimental Colitis Induced by Dextran Sodium Sulfate.International journal of molecular sciences · 2022Article
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Authors and funding
11 authors at 1 institution in 1 country.
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Abstract
Inflammatory bowel diseases (IBDs) are chronic intestinal diseases, frequently associated with comorbid psychological and cognitive deficits. These neuropsychiatric effects include anxiety, depression, and memory impairments that can be seen both during active disease and following remission and are more frequently seen in pediatric patients. The mechanism(s) through which these extraintestinal deficits develop remain unknown, and the study of these phenomenon is hampered by a lack of murine pediatric IBD models. Herein we describe microbiota-gut-brain (MGB) axis deficits following induction of colitis in a pediatric setting. Acute colitis was induced by administration of 2% dextran sodium sulfate (DSS) for 5 days starting at weaning [postnatal day (P)21] causing reduced weight gain, colonic shortening, and colonic inflammation by 8 days post-DSS (P29), which were mostly resolved in adult (P56) mice. Despite resolution of acute disease, cognitive deficits (novel object recognition task) and anxiety-like behavior (light/dark box) were identified in the absence of changes in exploratory behavior (open field test) in P56 mice previously treated with DSS at weaning. Behavioral deficits were found in conjunction with neuroinflammation, decreased neurogenesis, and altered expression of pattern recognition receptor genes in the hippocampus. Additionally, persistent alterations in the gut microbiota composition were observed at P56, including reduced butyrate-producing species. Taken together, these results describe for the first time the presence of MGB axis deficits following induction of colitis at weaning, which persist in adulthood.
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