Evidence map›Paper›PMID 32726136›Full record

ArticleCancer control : journal of the Moffitt Cancer Center

Validation of a Highly Sensitive qPCR Assay for the Detection of Plasma Cell-Free Epstein-Barr Virus DNA in Nasopharyngeal Carcinoma Diagnosis.

Vu Nguyen Quynh Anh, Nguyen Van Ba, Do Tram Anh, Nguyen Dinh Ung, Nguyen Hoang Hiep, Vu Thi Ly, Dinh Thi Thu Hang, Bui Tien Sy, Hoang Dao Chinh, Le Minh Ky and 8 more

Erratum issuedOpen access · goldAbstract readValidation Study
In one paragraph

Article in Cancer control : journal of the Moffitt Cancer Center. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 4 institutions in 1 country.

Vu Nguyen Quynh AnhDepartment of Genomics and Cytogenetics, Institute of Biomedicine & Pharmacy, Vietnam Military Medical University, Hanoi, Vietnam.
Nguyen Van BaOncology Centre, 103 Military Hospital, Vietnam Military Medical University, Hanoi, Vietnam.
Do Tram AnhENT Department, 103 Military Hospital, Vietnam Military Medical University, Hanoi, Vietnam.
Nguyen Dinh UngDepartment of Genomics and Cytogenetics, Institute of Biomedicine & Pharmacy, Vietnam Military Medical University, Hanoi, Vietnam.
Nguyen Hoang HiepDepartment of Genomics and Cytogenetics, Institute of Biomedicine & Pharmacy, Vietnam Military Medical University, Hanoi, Vietnam.ORCID https://orcid.org/0000-0002-6116-6106
Vu Thi LyDepartment of Genomics and Cytogenetics, Institute of Biomedicine & Pharmacy, Vietnam Military Medical University, Hanoi, Vietnam.
Dinh Thi Thu HangInstitute of Biomedicine & Pharmacy, Vietnam Military Medical University, Hanoi, Vietnam.
Bui Tien SyDepartment of Microbiology, 108 Military Central Hospital, Hanoi, Vietnam.
Hoang Dao ChinhDepartment of Oncology and Radiation, 108 Military Central Hospital, Hanoi, Vietnam.
Le Minh KyOncology and Head & Neck Surgery Centre, Vietnam National ENT Hospital, Hanoi, Vietnam.
Vu Truong PhongOncology and Head & Neck Surgery Centre, Vietnam National ENT Hospital, Hanoi, Vietnam.
Nguyen Kim LuuDepartment of Radiation, 103 Military Hospital, Vietnam Military Medical University, Hanoi, Vietnam.
Nguyen Thanh TrungHUS High School for Gifted Students, Hanoi, Vietnam.
Ho Anh SonInstitute of Biomedicine & Pharmacy, Vietnam Military Medical University, Hanoi, Vietnam.
Hoang Van LuongInstitute of Biomedicine & Pharmacy, Vietnam Military Medical University, Hanoi, Vietnam.
Nghiem Duc ThuanENT Department, 103 Military Hospital, Vietnam Military Medical University, Hanoi, Vietnam.
Ngo Thanh TungDepartment of Head & Neck Cancer and Radiation Oncology, Vietnam National K Hospital, Hanoi, Vietnam.
Ho Huu ThoDepartment of Genomics and Cytogenetics, Institute of Biomedicine & Pharmacy, Vietnam Military Medical University, Hanoi, Vietnam.ORCID https://orcid.org/0000-0002-8363-1427
Vietnam Military Medical University · VNVietnam National Children's Hospital · VN108 Military Central Hospital · VNLe Hong Phong High School for the Gifted · VN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Quantification of plasma cell-free Epstein Barr virus DNA (cf EBV DNA) has been suggested as a promising liquid biopsy assay for screening and early detection of nasopharyngeal carcinoma (NPC). However, the diagnostic value of this assay is currently not known in the population of Vietnam, one of the countries which contributed the most to the NPC cases. Herein, we have reported a highly sensitive quantitative polymerase chain reaction (qPCR)-based assay targeting cf EBV DNA for the detection of NPC. A standard curve with linear regression,

Indexed as

AdolescentAdultAgedBiomarkers, TumorCell-Free Nucleic AcidsDNA, ViralFemaleHumansLimit of DetectionLiquid BiopsyMaleMiddle AgedNasopharyngeal CarcinomaNasopharyngeal NeoplasmsReal-Time Polymerase Chain ReactionSensitivity and SpecificityBiomarkers, TumorCell-Free Nucleic AcidsDNA, Viralcell-free Epstein-Barr virus DNAearly detection of cancerliquid biopsynasopharyngeal carcinomaquantitative PCRVietnam

Identifiers

PMID32726136
PMCPMC7658724
OpenAlexW3046090199

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.