Evidence map›Paper›PMID 32725941›Full record

ArticlePediatric pulmonology2020

Association of patient weight status with plasma surfactant protein D, a biomarker of alveolar epithelial injury, in children with acute respiratory failure.

Shan L Ward, Mary K Dahmer, Heidi M Weeks, Anil Sapru, Michael W Quasney, Martha A Q Curley, Kathleen D Liu, Michael A Matthay, Heidi R Flori

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric pulmonology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00814099 (Sedation Management in Pediatric Patients With Acute Respiratory Failure), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00814099 nacompletednot on this map

Sedation Management in Pediatric Patients With Acute Respiratory Failure

TypeinterventionalSponsorUniversity of PennsylvaniaRan2009 to 2013Enrolled2,449ConditionsRespiratory Insufficiency, Respiratory Distress Syndrome, Newborn, Lung DiseasesArmsTeam approach to sedation management, Usual approach to sedation management
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Pathobiology, Severity, and Risk Stratification of Pediatric Acute Respiratory Distress Syndrome: From the Second Pediatric Acute Lung Injury Consensus Conference.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2023
    Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Shan L WardDivision of Critical Care, Department of Pediatrics, UCSF Benioff Children's Hospitals, San Francisco and Oakland, California.ORCID 0000-0002-1375-6240
Mary K DahmerDivision of Pediatric Critical Care Medicine, Department of Pediatrics, University of Michigan, Ann Arbor, Michigan.
Heidi M WeeksDepartment of Nutritional Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan.ORCID 0000-0003-3467-7987
Anil SapruDivision of Critical Care Medicine, Department of Pediatrics, Mattel Children's Hospital at UCLA Medical Center, Los Angeles, California.
Michael W QuasneyDivision of Pediatric Critical Care Medicine, Department of Pediatrics, University of Michigan, Ann Arbor, Michigan.
Martha A Q CurleyDivision of Anesthesia and Critical Care Medicine, Department of Family and Community Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Kathleen D LiuDepartment of Medicine, UCSF Medical Center, San Francisco, California.
Michael A MatthayDepartment of Anesthesia, UCSF Medical Center, San Francisco, California.
Heidi R FloriDivision of Pediatric Critical Care Medicine, Department of Pediatrics, University of Michigan, Ann Arbor, Michigan.
University of Michigan · USUniversity of California San Francisco Medical Center · USChildren's Hospital of Philadelphia · USRonald Reagan UCLA Medical Center · USUCSF Benioff Children's Hospital · US

Funding

Pediatric Critical Care Scientist Development ProgramK12HD047349 · NICHD · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI HEATHER T. KEENAN, Kevin M Watt · 2004 to 2026
$17.0M
Sedation Management in Pediatric Patients with Acute Respiratory FailureU01HL086622 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI CURLEY, MARTHA AQ · 2008 to 2013
$10.0M
Precision Medicine in the Acute Respiratory Distress SyndromeR35HL140026 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CALFEE, CAROLYN · 2018 to 2024
$6.8M
Ancillary to ABC PICU to study MOD in critically ill childrenR01HD092471 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PINEDA SOTO, JOSE ALFREDO, SAPRU, ANIL · 2017 to 2021
$2.4M
Sedation Management in Pediatric Patients with Acute Respiratory Failure (DCC)U01HL086649 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI WYPIJ, DAVID · 2008 to 2012
$2.0M
Genetic variation and biomarkers in children with acute lung injuryR01HL095410 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DAHMER, MARY K, FLORI, HEIDI R · 2009 to 2012
$1.8M
Coagulation and Fibrinolysis in Pediatric Insulin Titration TrialR01HL114484 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SAPRU, ANIL · 2012 to 2015
$1.6M
NHLBI NIH HHS HL0114484NHLBI NIH HHS HL086622NHLBI NIH HHS HL086649NHLBI NIH HHS HL095410NHLBI NIH HHS HL140026NHLBI NIH HHS R01 HL095410NHLBI NIH HHS R01 HL114484NHLBI NIH HHS R35 HL140026NHLBI NIH HHS U01 HL086622NHLBI NIH HHS U01 HL086649NICHD NIH HHS HD092471NICHD NIH HHS K12 HD047349NICHD NIH HHS K12HD047349NICHD NIH HHS R01 HD092471
6 · The paper itself

Abstract

AIMS AND

objectivesAlveolar epithelial injury is a key determinant of acute respiratory failure (ARF) severity. Plasma surfactant protein D (SP-D), a biomarker of alveolar epithelial injury, is lower in obese adults with ARF compared to their lean peers. We aimed to determine if children with ARF have similar variance in plasma SP-D associated with their weight status on admission.

methodsPlasma SP-D was measured on days 0, 1, or 2 in children (1-18 years) with ARF enrolled in the genetic variation and biomarkers in children with acute lung injury and RESTORE studies. Weight classification (underweight, normal, overweight, and obese) was based on body mass index or weight-for-height z-scores. Associations between weight group and SP-D on each day were tested.

resultsInclusion criteria were met in 212 subjects, 24% were obese. There were no differences among weight groups in SP-D levels on days 0 and 1. However, on day 2, there was a statistically significant linear trend for lower SP-D levels as weight increased in both the univariate analysis (P = .02) and when adjusting for age, ethnicity, and diagnosis of pediatric acute respiratory distress syndrome (P = .05).

conclusionsObesity was associated with lower plasma SP-D levels on day 2 of ARF. This finding may be explained by altered ARF pathogenesis in obese individuals or a reduced incidence of ventilator-induced lung injury.

Indexed as

Body WeightAdolescentBiomarkersBody Mass IndexChildChild, PreschoolFemaleHumansInfantMaleObesityPulmonary Surfactant-Associated Protein DRespiratory InsufficiencyBiomarkersPulmonary Surfactant-Associated Protein Dacute respiratory distress syndromeacute respiratory failurealveolar epithelial injurybody mass indexchildrenmechanical ventilationobesitypediatricsurfactant protein D

Identifiers

PMID32725941
PMCPMC8087214
OpenAlexW3046000129

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.