ReviewHuman brain mapping2022
What we learn about bipolar disorder from large-scale neuroimaging: Findings and future directions from the ENIGMA Bipolar Disorder Working Group.
Open access · goldAbstract readReview
In one paragraph
Review in Human brain mapping, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers, 9 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed, 9 pooled it
10.3field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
83 citing papers in PubMed, 9 syntheses or guidelines pooled it, 146 citations in OpenAlex.
- Psychotropic medications and their interactions with subcortical brain volume in bipolar disorder: An ENIGMA mega-analysis.Molecular psychiatry · 2026Pooled it
- Altered resting-state functional connectivity in bipolar disorder: a systematic review.Brain imaging and behavior · 2026Pooled it
- Lithium effects in the frontolimbic circuitry: a systematic review of neuroimaging findings in bipolar disorder.Translational psychiatry · 2026Pooled it
- Pooled it
- Machine learning for the diagnosis accuracy of bipolar disorder: a systematic review and meta-analysis.Frontiers in psychiatry · 2024Pooled it
- Smartphone-based interventions in bipolar disorder: Systematic review and meta-analyses of efficacy. A position paper from the International Society for Bipolar Disorders (ISBD) Big Data Task Force.Bipolar disorders · 2022Pooled it
- Epigenetic signatures relating to disease-associated genotypic burden in familial risk of bipolar disorder.Translational psychiatry · 2022Pooled it
- Cross disorder comparisons of brain structure in schizophrenia, bipolar disorder, major depressive disorder, and 22q11.2 deletion syndrome: A review of ENIGMA findings.Psychiatry and clinical neurosciences · 2022Pooled it
- Alterations in brain synaptic proteins and mRNAs in mood disorders: a systematic review and meta-analysis of postmortem brain studies.Molecular psychiatry · 2022Pooled it
- Cortical morphometry might predict currently prescribed vs. discontinued medications in bipolar disorder, even after controlling for the cumulative dose effects: An ENIGMA mega-analysis.Molecular psychiatry · 2026Article
- Inter-network Effective Connectivity During an Emotional Working Memory Task in Two Independent Samples of Young Adults.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Candidate Biomarkers of Bipolar Disorder Progression: Implications for Ketamine and Psychedelic Interventions.Molecular neurobiology · 2026Review
- Functional Outcome Prediction in Young Adults With Mental Health Symptoms Using Machine Learning and Large Language Models: Longitudinal Observational Study.JMIR mental health · 2026Observational
- Brainwide Structural Markers of Familial and Clinical Risk for Bipolar Disorder in Youth.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Structural Brain Network Alterations in Relation to Treatment and Illness Severity in Bipolar Disorder.Biological psychiatry · 2026Article
- Structural Brain Correlates of Childhood Inhibited Temperament: An ENIGMA-Anxiety Mega-Analysis.Journal of the American Academy of Child and Adolescent Psychiatry · 2026Article
- Structural Brain Network Alterations in Relation to Treatment and Illness Severity in Bipolar Disorder.bioRxiv : the preprint server for biology · 2026Article
- Multimodal EEG-fNIRS classification as a clinical tool for bipolar disorder diagnosis.Translational psychiatry · 2026Article
- Clinical characteristics and risk factors of antipsychotic-associated metabolic syndrome in bipolar disorder: a retrospective analysis.BMC psychiatry · 2026Article
- The spectrum of bipolar disorder in older adults.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
23 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
117 authors at 20 institutions in 22 countries.
Christopher R K ChingImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.ORCID 0000-0003-2921-3408
Derrek P HibarGenentech, Inc., South San Francisco, California, USA.
Tiril P GurholtNorwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway.ORCID 0000-0002-1272-7616
Abraham NunesDepartment of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.
Sophia I ThomopoulosImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Christoph AbéFaculty of Computer Science, Dalhousie University, Halifax, Nova Scotia, Canada.
Ingrid AgartzNorwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Rachel M BrouwerDepartment of Psychiatry, University Medical Center Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Dara M CannonCentre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland.
Sonja M C de ZwarteDepartment of Psychiatry, University Medical Center Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Lisa T EylerDepartment of Psychiatry, University of California, La Jolla, California, USA.
Pauline FavreINSERM U955, team 15 "Translational Neuro-Psychiatry", Créteil, France.
Tomas HajekDivision of Mental Health and Addicition, Oslo University Hospital, Oslo, Norway.ORCID 0000-0003-0281-8458
Unn K HaukvikDivision of Mental Health and Addicition, Oslo University Hospital, Oslo, Norway.ORCID 0000-0002-0363-4127
Josselin HouenouINSERM U955, team 15 "Translational Neuro-Psychiatry", Créteil, France.
Mikael LandénDepartment of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden.
Tristram A LettDepartment for Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Berlin, Germany.
Colm McDonaldDepartment of Psychiatry, University Medical Center Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Leila NabulsiImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Yash PatelBloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, Toronto, Ontario, Canada.
Melissa E PaulingDesert-Pacific MIRECC, VA San Diego Healthcare, San Diego, California, USA.
Tomas PausBloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, Toronto, Ontario, Canada.
Joaquim RaduaDepartment of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway.
Marcio G Soeiro-de-SouzaMood Disorders Unit (GRUDA), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.
Giulia TronchinDepartment of Psychiatry, University Medical Center Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Neeltje E M van HarenDepartment of Child and Adolescent Psychiatry/Psychology, Erasmus Medical Center, Rotterdam, The Netherlands.
Eduard VietaInstitut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Barcelona, Spain.
Henrik WalterDepartment for Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Berlin, Germany.
Ling-Li ZengImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Martin AldaDivision of Mental Health and Addicition, Oslo University Hospital, Oslo, Norway.
Jorge AlmeidaDell Medical School, The University of Texas at Austin, Austin, Texas, USA.
Dag AlnaesNorwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Silvia Alonso-LanaFIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain.
Cara AltimusMilken Institute Center for Strategic Philanthropy, Washington, District of Columbia, USA.
Michael BauerDepartment of Psychiatry and Psychotherapy, Medical Faculty, Technische Universität Dresden, Dresden, Germany.
Bernhard T BauneDepartment of Psychiatry, University of Münster, Münster, Germany.
Carrie E BeardenDepartment of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, California, USA.ORCID 0000-0002-8516-923X
Marcella BellaniSection of Psychiatry, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
Francesco BenedettiVita-Salute San Raffaele University, Milan, Italy.
Michael BerkDepartment of Pathophysiology and Transplantation, University of Milan, Milan, Italy.
Amy C BilderbeckThe National Centre of Excellence in Youth Mental Health, Centre for Youth Mental Health, Florey Institute for Neuroscience and Mental Health and the Department of Psychiatry, The University of Melbourne, Orygen, Melbourne, Victoria, Australia.
Hilary P BlumbergDepartment of Psychiatry, University of Oxford, Oxford, UK.
Erlend BøenMood Disorders Research Program, Yale School of Medicine, New Haven, Connecticut, USA.
Irene BollettiniDivision of Neuroscience, Psychiatry and Psychobiology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Caterina Del Mar BonninInstitut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Barcelona, Spain.
Paolo BrambillaPsychosomatic and CL Psychiatry, Oslo University Hospital, Oslo, Norway.
Erick J Canales-RodríguezFIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain.
Xavier CaserasMRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
Orwa DandashMelbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Melbourne, Victoria, Australia.
Udo DannlowskiDepartment of Psychiatry, University of Münster, Münster, Germany.
Giuseppe DelvecchioPsychosomatic and CL Psychiatry, Oslo University Hospital, Oslo, Norway.
Ana M Díaz-ZuluagaResearch Group in Psychiatry GIPSI, Department of Psychiatry, Faculty of Medicine, Universidad de Antioquia, Medellín, Colombia.
Danai DimaDepartment of Psychology, School of Social Sciences and Arts, City, University of London, London, UK.
Édouard DuchesnayINSERM U955, team 15 "Translational Neuro-Psychiatry", Créteil, France.
Torbjørn ElvsåshagenNorwegian Centre for Mental Disorders Research (NORMENT), Oslo University Hospital, Oslo, Norway.
Scott C FearsCenter for Neurobehavioral Genetics, Los Angeles, California, USA.
Sophia FrangouCentre for Brain Health, University of British Columbia, Vancouver, British Columbia, Canada.
Janice M FullertonNeuroscience Research Australia, Randwick, New South Wales, Australia.
David C GlahnDepartment of Psychiatry, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0002-4749-6977
Jose M GoikoleaInstitut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Barcelona, Spain.
Melissa J GreenNeuroscience Research Australia, Randwick, New South Wales, Australia.
Dominik GrotegerdDepartment of Psychiatry, University of Münster, Münster, Germany.
Oliver GruberDepartment of General Psychiatry, Heidelberg University, Heidelberg, Germany.
Bartholomeus C M HaarmanDepartment of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.ORCID 0000-0002-9006-8863
Chantal HenryDepartment of Psychiatry, Service Hospitalo-Universitaire, GHU Paris Psychiatrie & Neurosciences, Paris, France.
Fleur M HowellsNeuroscience Institute, University of Cape Town, Cape Town, South Africa.ORCID 0000-0001-9759-2556
Victoria Ives-DeliperiNeuroscience Institute, University of Cape Town, Cape Town, South Africa.
Andreas JansenCore-Facility Brainimaging, Faculty of Medicine, University of Marburg, Marburg, Germany.
Tilo T J KircherDepartment of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany.
Christian KnöchelDepartment of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University Frankfurt, Frankfurt, Germany.
Bernd KramerDepartment of General Psychiatry, Heidelberg University, Heidelberg, Germany.
Beny LaferLaboratory of Psychiatric Neuroimaging (LIM-21), Departamento e Instituto de Psiquiatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.
Carlos López-JaramilloResearch Group in Psychiatry GIPSI, Department of Psychiatry, Faculty of Medicine, Universidad de Antioquia, Medellín, Colombia.
Rodrigo Machado-VieiraExperimental Therapeutics and Molecular Pathophysiology Program, Department of Psychiatry, UTHealth, University of Texas, Houston, Texas, USA.
Bradley J MacIntoshHurvitz Brain Sciences, Sunnybrook Research Institute, Toronto, Ontario, Canada.ORCID 0000-0001-7300-2355
Elisa M T MelloniVita-Salute San Raffaele University, Milan, Italy.
Philip B MitchellSchool of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia.
Igor NenadicDepartment of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany.
Fabiano NeryUniversity of Cincinnati, Cincinnati, Ohio, USA.
Allison C NugentMEG Core Facility, Bethesda, Maryland, USA.
Viola OertelDepartment of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University Frankfurt, Frankfurt, Germany.
Roel A OphoffUCLA Center for Neurobehavioral Genetics, Los Angeles, California, USA.
Miho OtaDepartment of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan.
Bronwyn J OversNeuroscience Research Australia, Randwick, New South Wales, Australia.
Daniel L PhamMilken Institute Center for Strategic Philanthropy, Washington, District of Columbia, USA.
Mary L PhillipsDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Julian A Pineda-ZapataResearch Group, Instituto de Alta Tecnología Médica (IATM), Medellín, Colombia.
Sara PolettiVita-Salute San Raffaele University, Milan, Italy.
Mircea PolosanUniversity of Grenoble Alpes, CHU Grenoble Alpes, Grenoble, France.
Edith Pomarol-ClotetFIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain.
Arnaud PouchonUniversity of Grenoble Alpes, CHU Grenoble Alpes, Grenoble, France.
Yann QuidéNeuroscience Research Australia, Randwick, New South Wales, Australia.ORCID 0000-0002-8569-7139
Maria M RiveDepartment of Psychiatry, Amsterdam UMC, location AMC, Amsterdam, The Netherlands.
Gloria RobertsSchool of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia.
Henricus G RuheDepartment of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands.
Raymond SalvadorFIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain.
Salvador SarróFIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain.
Theodore D SatterthwaiteDepartment of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Aart H ScheneDepartment of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands.
Kang SimWest Region, Institute of Mental Health, Singapore, Singapore.
Jair C SoaresCenter of Excellent on Mood Disorders, UTHealth Houston, Houston, Texas, USA.
Michael StäbleinDepartment of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University Frankfurt, Frankfurt, Germany.
Dan J SteinNeuroscience Institute, University of Cape Town, Cape Town, South Africa.
Christian K TamnesNorwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Georgios V ThomaidisPapanikolaou General Hospital, Thessaloniki, Greece.
Cristian Vargas UpeguiResearch Group in Psychiatry GIPSI, Department of Psychiatry, Faculty of Medicine, Universidad de Antioquia, Medellín, Colombia.ORCID 0000-0002-2621-2920
Dick J VeltmanDepartment of Psychiatry, Amsterdam UMC, Amsterdam, The Netherlands.
Michèle WessaDepartment of Neuropsychology and Clinical Psychology, Johannes Gutenberg-University Mainz, Mainz, Germany.
Lars T WestlyeDepartment of Psychology, University of Oslo, Oslo, Norway.
Heather C WhalleyCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
Daniel H WolfDepartment of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Mon-Ju WuDepartment of Psychiatry and Behavioral Sciences, UTHealth Houston, Houston, Texas, USA.
Lakshmi N YathamDepartment of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada.
Carlos A ZarateChief Experimental Therapeutics & Pathophysiology Branch, Bethesda, Maryland, USA.
Paul M ThompsonImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Ole A AndreassenNorwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
ENIGMA Bipolar Disorder Working Group
Oslo University Hospital · NOCentro de Investigación Biomédica en Red de Salud Mental · ESInserm · FRUniversity of Southern California · USUNSW Sydney · AUUtrecht University · NLVita-Salute San Raffaele University · ITGoethe University Frankfurt · DEPhilipps University of Marburg · DEThe University of Melbourne · AUThe University of Texas Health Science Center at Houston · USUniversidad de Antioquia · COUniversity of Oslo · NOCharité - Universitätsmedizin Berlin · DEDalhousie University · CAErasmus MC · NLHeidelberg University · DEHospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo · BRMilken Institute · USRadboud University Nijmegen · NL
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MGlutamatergic Modulators for Rapid & Sustained Antidepressant EffectZIAMH002857 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI ZARATE, CARLOS · 2009 to 2025
$55.0MTarget validation of novel therapeutic agents in mood disordersZIAMH002927 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI ZARATE, CARLOS · 2010 to 2025
$37.1MNIMH MEG Core FacilityZICMH002889 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI NUGENT, ALLISON · 2009 to 2025
$31.4MThe Center for Neuroscience-based Mental Health Assessment and Prediction (NEUROMAP)P20GM121312 · NIGMS · LAUREATE INSTITUTE FOR BRAIN RESEARCH · PI MARTIN P. PAULUS · 2017 to 2026
$23.7MChildren of Bipolar Parents: A High Risk Follow Up Study (also known as Bipolar Offspring Study - BIOS)R01MH060952 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BIRMAHER, BORIS, PHILLIPS, MARY LOUISE · 2001 to 2020
$20.4MCourse and Outcome of Bipolar Disorder in Youth - SupplementR01MH059929 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BIRMAHER, BORIS, PHILLIPS, MARY LOUISE · 2000 to 2021
$15.9MTraining U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1MGenomic Studies of Bipolar Disorder in a Large Cohort from The NetherlandsR01MH090553 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI OPHOFF, ROEL A · 2010 to 2014
$6.0MReward, impulsive sensation seeking and emotional dysregulation: neural mechanisms underlying risk for bipolar disorder in young adultsR37MH100041 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Mary Louise Phillips · 2019 to 2026
$5.8MGene Networks Influencing Psychotic Dysconnectivity in African AmericansR01MH106324 · NIMH · YALE UNIVERSITY · PI BLANGERO, JOHN, GLAHN, DAVID C · 2015 to 2019
$4.2MBipolar Endophenotypes in Population IsolatesR01MH075007 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FREIMER, NELSON B. · 2007 to 2011
$3.8MDepartment of HealthMedical Research Council MC_PC_17209Medical Research Council MR/L010305/1Medical Research Council MR/S035818/1NCATS NIH HHS UL1 TR001863NIA NIH HHS R56 AG058854NIA NIH HHS T32 AG058507NIBIB NIH HHS U54 EB020403NIGMS NIH HHS P20 GM121312NIMH NIH HHS K08 MH086786NIMH NIH HHS K23 MH074644NIMH NIH HHS K23 MH085096NIMH NIH HHS K23 MH098130NIMH NIH HHS R01 MH059929NIMH NIH HHS R01 MH060952NIMH NIH HHS R01 MH075007NIMH NIH HHS R01 MH076971NIMH NIH HHS R01 MH080912NIMH NIH HHS R01 MH083968NIMH NIH HHS R01 MH085667NIMH NIH HHS R01 MH090553NIMH NIH HHS R01 MH095454NIMH NIH HHS R01 MH096957NIMH NIH HHS R01 MH100041NIMH NIH HHS R01 MH101111NIMH NIH HHS R01 MH106324NIMH NIH HHS R01 MH107703NIMH NIH HHS R01 MH116147NIMH NIH HHS R03 MH105808NIMH NIH HHS R21 MH113871NIMH NIH HHS R37 MH100041NIMH NIH HHS T32 MH073526Wellcome TrustWellcome Trust 104036/Z/14/ZWellcome Trust 216767/Z/19/Z
Abstract
MRI-derived brain measures offer a link between genes, the environment and behavior and have been widely studied in bipolar disorder (BD). However, many neuroimaging studies of BD have been underpowered, leading to varied results and uncertainty regarding effects. The Enhancing Neuro Imaging Genetics through Meta-Analysis (ENIGMA) Bipolar Disorder Working Group was formed in 2012 to empower discoveries, generate consensus findings and inform future hypothesis-driven studies of BD. Through this effort, over 150 researchers from 20 countries and 55 institutions pool data and resources to produce the largest neuroimaging studies of BD ever conducted. The ENIGMA Bipolar Disorder Working Group applies standardized processing and analysis techniques to empower large-scale meta- and mega-analyses of multimodal brain MRI and improve the replicability of studies relating brain variation to clinical and genetic data. Initial BD Working Group studies reveal widespread patterns of lower cortical thickness, subcortical volume and disrupted white matter integrity associated with BD. Findings also include mapping brain alterations of common medications like lithium, symptom patterns and clinical risk profiles and have provided further insights into the pathophysiological mechanisms of BD. Here we discuss key findings from the BD working group, its ongoing projects and future directions for large-scale, collaborative studies of mental illness.
Indexed as
Bipolar DisorderCerebral CortexMagnetic Resonance ImagingNeuroimagingHumansMeta-Analysis as TopicMulticenter Studies as Topicbipolar disordercortical surface areacortical thicknessENIGMAmega-analysismeta-analysisMRIneuroimagingpsychiatryvolume
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