Evidence map›Paper›PMID 32725839›Full record

ArticleJournal of clinical laboratory analysis2020

Prediction for cardiovascular diseases based on laboratory data: An analysis of random forest model.

Xi Su, Yongyong Xu, Zhijun Tan, Xia Wang, Peng Yang, Yani Su, Yangyang Jiang, Sijia Qin, Lei Shang

Abstract read
In one paragraph

Article in Journal of clinical laboratory analysis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xi SuDepartment of Health Statistics, Fourth Military Medical University, Xi'an, China.
Yongyong XuDepartment of Health Statistics, Fourth Military Medical University, Xi'an, China.
Zhijun TanDepartment of Health Statistics, Fourth Military Medical University, Xi'an, China.
Xia WangDepartment of Health Statistics, Fourth Military Medical University, Xi'an, China.
Peng YangDepartment of Health Statistics, Fourth Military Medical University, Xi'an, China.
Yani SuData Center, Shaanxi Provincial People's Hospital, Xi'an, China.
Yangyang JiangSchool of Health Management, Xi'an Medical University, Xi'an, China.
Sijia QinSchool of Stomatology, Xi'an Medical University, Xi'an, China.
Lei ShangDepartment of Health Statistics, Fourth Military Medical University, Xi'an, China.ORCID https://orcid.org/0000-0002-3330-5391

Funding

Special Scientific Research Program of Department of Education of Shaanxi Province 19JK0770
6 · The paper itself

Abstract

backgroundTo establish a prediction model for cardiovascular diseases (CVD) in the general population based on random forests.

methodsA retrospective study involving 498 subjects was conducted in Xi'an Medical University between 2011 and 2018. The random forest algorithm was used to screen out the variables that greatly affected the CVD prediction and to establish a prediction model. The important variables were included in the multifactorial logistic regression analysis. The area under the curve (AUC) was compared between logistic regression model and random forest model.

resultsThe random forest model revealed the variables, including the age, body mass index (BMI), fasting blood glucose (FBG), diastolic blood pressure (DBP), triglyceride (TG), systolic blood pressure (SBP), total cholesterol (TC), waist circumference, and high-density lipoprotein-cholesterol (HDL-C), were more significant for CVD prediction; the AUC was 0.802 in CVD prediction. Multifactorial logistic regression analysis indicated that the risk factors for CVD included the age [odds ratio (OR): 1.14, 95% confidence intervals (CI): 1.10-1.17, P < .001], BMI (OR: 1.13, 95% CI: 1.06-1.20, P < .001), TG (OR: 1.11, 95% CI: 1.02-1.22, P = .023), and DBP (OR: 1.04, 95% CI: 1.02-1.06, P = .001); the AUC was 0.843 in CVD prediction. The established logistic regression prediction model was Logit P = Log[P/(1 - P)] = -11.47 + 0.13 × age + 0.12 × BMI + 0.11 × TG + 0.04 × DBP; P = 1/[1 + exp(-Logit P)]. People were prone to develop CVD at the time of P > .51.

conclusionsA prediction model for CVD is developed in the general population based on random forests, which provides a simple tool for the early prediction of CVD.

Indexed as

Heart Disease Risk FactorsModels, StatisticalAdultAlgorithmsCardiovascular DiseasesDecision TreesFemaleHumansMachine LearningMaleMiddle AgedRetrospective Studiescardiovascular diseaseprediction modelrandom forestrisk factors

Identifiers

PMID32725839
PMCPMC7521325

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.