ArticlePhysiological reports2020
Allometric scaling patterns among the human coronary artery tree, myocardial mass, and coronary artery flow.
Article in Physiological reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systematic review and meta-analysis of Murray's law in the coronary arterial circulation.American journal of physiology. Heart and circulatory physiology · 2024Pooled it
- Performance of a Novel Computational Hyperemic Resistance Index Derived from Cardiac CT in Coronary Chronic Syndromes.Journal of clinical medicine · 2025Article
- Sensitivity of coronary hemodynamics to vascular structure variations in health and disease.Scientific reports · 2025Article
- Relative Residence Time Can Account for Half of the Anatomical Variation in Fatty Streak Prevalence Within the Right Coronary Artery.Annals of biomedical engineering · 2025Article
- Coronary CT angiography-based estimation of myocardial perfusion territories for coronary artery FFR and wall shear stress simulation.Scientific reports · 2021Article
- Branching principles of animal and plant networks identified by combining extensive data, machine learning and modelling.Journal of the Royal Society, Interface · 2021Article
- Allometric scaling patterns among the human coronary artery tree, myocardial mass, and coronary artery flow.Physiological reports · 2020Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human coronary artery tree is a physiological transport system for oxygen and vital materials through a hierarchical vascular network to match the energy demands of myocardium, which has the highest oxygen extraction ratio among body organs and heavily depends on the blood flow for its energy supply. Therefore, it would be reasonable to expect that the key design principle of this arterial network is to minimize energy expenditure, which can be described by allometric scaling law. We enrolled patients who underwent coronary computed tomography angiography without obstructive lesion. The cumulative arterial length (L), volume (V), and diameter (D) in relation to the artery-specific myocardial mass (M) were assessed. Flow rate (Q) was computed using quantitative flow ratio (QFR) measurement in patients who underwent invasive angiography. A total of 638 arteries from 43 patients (mean age 61 years, male gender 65%) were analyzed. A significant power-law relationship was found among L-M, V-M, D-M, V-L, D-L, and V-D, and also among Q-M, Q-L, Q-V, and Q-D in 106 arteries interrogated with QFR (p < .001, all). Our results suggest that the fundamental design principle of the human coronary arterial network may follow allometric scaling law.
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