ReviewAnnals of the New York Academy of Sciences2021
Rotator cuff tear degeneration and the role of fibro-adipogenic progenitors.
Review in Annals of the New York Academy of Sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 44 citations in OpenAlex.
- Phenotypic divergence in rotator cuff tear and volumetric muscle loss mouse models following fibroadipogenic progenitor depletion.Bone & joint research · 2026Article
- Postoperative exercise modulating gut microbiota and associated metabolites to facilitate bone-tendon healing in rotator cuff tears.BMC musculoskeletal disorders · 2026Article
- The correlation between torn supraspinatus tendon thickness and commonly used radiological predictive factors for repairability in rotator cuff tears.BMC musculoskeletal disorders · 2026Article
- Proteomic biomarkers in rotator cuff disease: Current evidence and translational implications from a systematic review and network analysis.Journal of orthopaedic translation · 2026Review
- Review
- Tendon-muscle-nerve disconnection in chronic large and massive posterosuperior rotator cuff tears: a targeted narrative mechanistic review and hypothesis-generating framework.Frontiers in cell and developmental biology · 2026Review
- Mitochondrial transfer and transplantation in tendon, ligament, and enthesis repair: current evidence, mechanistic rationale, and regenerative opportunities.Frontiers in cell and developmental biology · 2026Review
- Tanshinone IIA suppresses fibro-adipogenic progenitor differentiation and attenuates fat infiltration in rotator cuff injury via Wnt/β-catenin pathway.Regenerative therapy · 2025Article
- Efficacy analysis of high-intensity laser therapy for post lumbar surgery syndrome.Scientific reports · 2025Article
- Unravelling the Role of PIEZO1 in Adipogenesis of Fibrogenic/Adipogenic Progenitors for Muscle Fat Infiltration After Rotator Cuff Tear.Journal of cachexia, sarcopenia and muscle · 2025Article
- Muscle Health & Fatty Infiltration with Advanced Rotator Cuff Pathology.Current reviews in musculoskeletal medicine · 2025Review
- Fat Expansion Not Fat Infiltration of Muscle Post Rotator Cuff Tendon Tears of the Shoulder: Regenerative Engineering Implications.Regenerative engineering and translational medicine · 2025Article
- PIEZO1 activation enhances myogenesis and mitigates muscle degeneration in rotator cuff tear.Regenerative therapy · 2025Article
- PdgfrαGenes & diseases · 2025Review
- Oestrogen suppresses the adipogenesis of fibro/adipogenic progenitors through reactivating the METTL3-ESR1-mediated loop in post-menopausal females.Clinical and translational medicine · 2025Article
- Hierarchy Reproduction: Multiphasic Strategies for Tendon/Ligament-Bone Junction Repair.Biomaterials research · 2025Review
- Overexpression of PRDM16 improves muscle function after rotator cuff tears.Journal of shoulder and elbow surgery · 2024Article
- Transcriptional evidence for transient regulation of muscle regeneration by brown adipose transplant in the rotator cuff.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2024Article
- Exosomes derived from bone marrow mesenchymal stem cell preconditioned by low-intensity pulsed ultrasound stimulation promote bone-tendon interface fibrocartilage regeneration and ameliorate rotator cuff fatty infiltration.Journal of orthopaedic translation · 2024Article
- Ginsenoside Rb1 regulates CPT1A deacetylation to inhibit intramuscular fat infiltration after rotator cuff tear.iScience · 2024Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The high prevalence of rotator cuff tears poses challenges to individual patients and the healthcare system at large. This orthopedic injury is complicated further by high rates of retear after surgical repair. Outcomes following repair are highly dependent upon the quality of the injured rotator cuff muscles, and it is, therefore, crucial that the pathophysiology of rotator cuff degeneration continues to be explored. Fibro-adipogenic progenitors, a major population of resident muscle stem cells, have emerged as the main source of intramuscular fibrosis and fatty infiltration, both of which are key features of rotator cuff muscle degeneration. Improvements to rotator cuff repair outcomes will likely require addressing the muscle pathology produced by these cells. The aim of this review is to summarize the current rotator cuff degeneration assessment tools, the effects of poor muscle quality on patient outcomes, the role of fibro-adipogenic progenitors in mediating muscle pathology, and how these cells could be leveraged for potential therapeutics to augment current rotator cuff surgical and rehabilitative strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.