Evidence map›Paper›PMID 32725596›Full record

ArticleInfection2021

Absent immune response to SARS-CoV-2 in a 3-month recurrence of coronavirus disease 2019 (COVID-19) case.

Guosheng Gao, Zhe Zhu, Lingyan Fan, Shuyuan Ye, Zuoan Huang, Qiaoyun Shi, Yedan Sun, Qifa Song

Abstract readCase Reports
In one paragraph

Article in Infection, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 5 syntheses or guidelines pooled it.

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  5. Is recurrence possible in coronavirus disease 2019 (COVID-19)? Case series and systematic review of literature.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2021
    Pooled it
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  19. Recurrence of SARS-CoV-2 viral RNA in recovered COVID-19 patients: a narrative review.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Guosheng Gao *Department of Clinical Laboratory, HwaMei Hospital, University of Chinese Academy of Sciences, Ningbo, China.
Zhe Zhu *Ningbo Institute of Life and Health Industry, University of Chinese Academy of Sciences, Ningbo, China.
Lingyan FanNingbo Institute of Life and Health Industry, University of Chinese Academy of Sciences, Ningbo, China.
Shuyuan YeDepartment of Clinical Laboratory, HwaMei Hospital, University of Chinese Academy of Sciences, Ningbo, China.
Zuoan HuangNingbo Institute of Life and Health Industry, University of Chinese Academy of Sciences, Ningbo, China.
Qiaoyun ShiNingbo Institute of Life and Health Industry, University of Chinese Academy of Sciences, Ningbo, China.
Yedan SunDepartment of Laboratory, Cixi Center for Disease Control and Prevention, Ningbo, China.
Qifa SongCentral Laboratory, Ningbo City First Hospital, Zhejiang Province, Ningbo, China. qifasong@126.com.ORCID http://orcid.org/0000-0001-9753-2924

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe viral persistence in patients with Coronavirus Disease 2019 (COVID-19) remains to be investigated.

methodsWe investigated the viral loads, therapies, clinical features, and immune responses in a 70-year patient tested positive for SARS-CoV-2 for 3 months.

findingsThe patient exhibited the highest prevalence of abnormal indices of clinical features and immune responses at the first admission, including fever (38.3 ℃), decreased lymphocytes (0.83 × 10

conclusionsThe patient displayed declining immune responses in spite of the viral shedding for 3 months. We inferred the declining immune responses might result from the segregation of the virus from the immune system.

Indexed as

AgedAntiviral AgentsBiomarkersCOVID-19COVID-19 TestingC-Reactive ProteinCreatinineFeverHospitalizationHumansImmunityInterferon-gammaInterleukin-10Interleukin-2Interleukin-6LymphopeniaAntiviral AgentsBiomarkersC-Reactive ProteinCreatinineIFNG protein, humanIL6 protein, humanInterferon-gammaInterleukin-10Interleukin-2Interleukin-6Tumor Necrosis Factor-alphaCoronavirus disease 2019 (COVID-19)Immune responseLong-term viral sheddingNovel coronavirus (SARS-CoV-2)Recurrence

Identifiers

PMID32725596
PMCPMC7386381

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.