Evidence map›Paper›PMID 32725468›Full record

ArticleAging clinical and experimental research2021

TOMM40 and APOE variants synergistically increase the risk of Alzheimer's disease in a Chinese population.

Zheng Zhu, Yang Yang, Zhenxu Xiao, Qianhua Zhao, Wanqing Wu, Xiaoniu Liang, Jianfeng Luo, Yang Cao, Minhua Shao, Qihao Guo and 1 more

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Article in Aging clinical and experimental research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. International journal of molecular sciences · 2023
    Article
  11. Alzheimer's Disease: An Updated Overview of Its Genetics.International journal of molecular sciences · 2023
    Review
  12. Genes · 2021
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 3 countries.

Zheng Zhu *Institute of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
Yang Yang *Guanghan Personal Health Research Institute, Shanghai, China.
Zhenxu XiaoInstitute of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
Qianhua ZhaoInstitute of Neurology, Huashan Hospital, Fudan University, Shanghai, China. applenasa@hotmail.com.ORCID http://orcid.org/0000-0001-5655-158X
Wanqing WuInstitute of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
Xiaoniu LiangInstitute of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
Jianfeng LuoDepartment of Biostatistics, School of Public Health, Fudan University, Shanghai, China.
Yang CaoClinical Epidemiology and Biostatistics, School of Medical Sciences, Örebro University, Örebro, Sweden.
Minhua ShaoGuanghan Personal Health Research Institute, Shanghai, China.
Qihao GuoInstitute of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
Ding DingInstitute of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
Fudan University · CNÖrebro University · SE

Funding

National Chronic Disease Project 2016YFC1306402National Natural Science Foundation of China 81773513Natural Science Foundation and Major Basic Research Program of Shanghai 16JC1420100Scientific Research Projects from Shanghai Science and Technology Municipality (STCSM) 17411950106Scientific Research Projects from Shanghai Science and Technology Municipality (STCSM) 17411950701Shanghai Brain-Intelligence Project from STCSM 16JC1420500STCSM Major Project 2018SHZDZX01
6 · The paper itself

Abstract

backgroundThe apolipoprotein E (APOE) ε4 allele is a strong risk factor for Alzheimer's disease (AD) in Caucasian and African American populations. It suggests that other genetic factors may modulate AD pathogenesis in Chinese populations, among which the frequency of this allele is reduced but the AD prevalence is maintained. The translocase of outer mitochondrial membrane 40 (TOMM40), which is located adjacent to APOE, may play an APOE-dependent role in modulating AD pathogenesis.

aimsThis work aimed to investigate whether TOMM40 polymorphisms modulate AD risk independently of, or in conjunction with APOE polymorphisms in Chinese populations.

methodsWe conducted a case-control study including 834 patients with AD recruited from the Memory Clinic and 643 cognitively normal participants recruited from the community. The Taqman SNP method was used for APOE genotyping, while TOMM40 polymorphism genotyping was conducted via a polymerase chain reaction-ligase detection reaction.

resultsThe TOMM40 rs10119 and rs71352238 alleles were associated with AD independently of the patient APOE status. The rs10119 AA genotype and rs71352238 CC genotype were risk genotypes of AD. Individuals carrying a TOMM40 rs10119 GG/APOE ε4+ (OR, 3.73; 95% CI 1.49-9.37; P = 0.005), TOMM40 rs10119 AG/APOE ε4+ (OR, 4.16; 95% CI 3.30-5.24; P < 0.001), or TOMM40 rs10119 AA/APOE ε4+ (OR, 14.78; 95% CI 8.56-25.54; P < 0.001) genotype exhibited a significantly higher AD risk. Those carrying a TOMM40 rs71352238 TT/APOE ε4+ (OR, 3.82; 95% CI 2.32-6.29; P < 0.001), TOMM40 rs71352238 CT/APOE ε4+ (OR, 4.40; 95% CI 3.46-5.56; P < 0.001), or TOMM40 rs71352238 CC/APOE ε4+ (OR, 14.02; 95% CI 7.81-25.17; P < 0.001) genotype also exhibited a significantly increased AD risk. DISCUSSION AND

conclusionsThis study provides invaluable insights into the mechanisms underlying the prevalence of AD in Chinese populations, and supports that simultaneous TOMM40 and APOE genotyping in the clinical setting may identify individuals at high risk of developing AD.

Indexed as

Alzheimer DiseaseApolipoprotein E4Membrane Transport ProteinsAllelesCase-Control StudiesChinaGenetic Predisposition to DiseaseGenotypeHumansMitochondrial Precursor Protein Import Complex ProteinsRisk FactorsApolipoprotein E4Membrane Transport ProteinsMitochondrial Precursor Protein Import Complex ProteinsTOMM40 protein, humanAlleleAlzheimer’s diseaseAPOECase–control studySingle nucleotide polymorphismTOMM40

Identifiers

PMID32725468
OpenAlexW3045704472

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.