ArticleMedizinische Klinik, Intensivmedizin und Notfallmedizin2020
[Hepatic dysfunction in sepsis].
Article in Medizinische Klinik, Intensivmedizin und Notfallmedizin, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 14 citations in OpenAlex.
- Age- and Sex-Related Outcomes in Patients with Sepsis or Septic Shock: A Prospective Monocentric Cohort Study.Journal of clinical medicine · 2026Article
- Effects of fullerenol CExperimental and therapeutic medicine · 2026Article
- [Core curriculum of intensive care and emergency medicine in internal medicine].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2025Review
- Sepsis and the Liver.Diseases (Basel, Switzerland) · 2025Review
- Mesenchymal stem cells in sepsis-induced organ dysfunction: mechanisms and therapeutic potential.Stem cell research & therapy · 2025Review
- Myocardial blood flow in patients with sepsis.Physiological reports · 2025Article
- Role of GLP‑1 receptor agonists in sepsis and their therapeutic potential in sepsis‑induced muscle atrophy (Review).International journal of molecular medicine · 2025Review
- Liver injury in sepsis: manifestations, mechanisms and emerging therapeutic strategies.Frontiers in immunology · 2025Review
- Interpretable mortality prediction model for ICU patients with pneumonia: using shapley additive explanation method.BMC pulmonary medicine · 2024Article
- [Liver diseases in the intensive care unit].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2024Review
- Interleukin 1 β suppresses bile acid-induced BSEP expression via a CXCR2-dependent feedback mechanism.PloS one · 2024Article
- Roquin-1 resolves sepsis-associated acute liver injury by regulating inflammatory profiles via miRNA cargo in extracellular vesicles.iScience · 2023Article
- Immunomodulation by Hemoadsorption-Changes in Hepatic Biotransformation Capacity in Sepsis and Septic Shock: A Prospective Study.Biomedicines · 2022Article
- The liver in sepsis: molecular mechanism of liver failure and their potential for clinical translation.Molecular medicine (Cambridge, Mass.) · 2022Review
- Screening of ferroptosis-related genes in sepsis-induced liver failure and analysis of immune correlation.PeerJ · 2022Article
- [Core curriculum Medical intensive care medicine of the German Society of Medical Intensive Care and Emergency Medicine (DGIIN)].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2021Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sepsis represents a life-threatening condition that frequently accompanies acute hepatic dysfunction. As a result of systemic inflammation, immune dysregulation, and microcirculatory derangements, different types of liver dysfunction can occur, such as hypoxic hepatitis, sepsis-associated cholestasis, or liver failure. A very serious and late sequela is secondary sclerosing cholangitis of the critically ill patient. Clinical management of sepsis-related liver dysfunction includes the rapid identification and treatment of the suspected underlying infection, hemodynamic stabilization to improve hepatic perfusion, and the optimization of oxygen delivery to the liver. Despite maximum efforts in supportive treatment, the outcome of patients with sepsis or septic shock and concomitant severe hepatic dysfunction remains very poor.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.