Evidence map›Paper›PMID 32725315›Full record

ReviewArchives of orthopaedic and trauma surgery2021

Comparison between intra-articular infiltrations of placebo, steroids, hyaluronic and PRP for knee osteoarthritis: a Bayesian network meta-analysis.

Filippo Migliorini, Arne Driessen, Valentin Quack, Nadja Sippel, Brian Cooper, Yasser El Mansy, Markus Tingart, Jörg Eschweiler

2 registry-linked trialsAbstract readComparative StudyReviewNetwork Meta-Analysis
PubMed Publisher
In one paragraph

Review in Archives of orthopaedic and trauma surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 84 papers, 16 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed, 16 pooled it
13.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06032039 early_phase1unknown statusnot on this mapstarted 2023, after this paper: background citation

Corticosteroid vs Platelet-Rich Plasma Intra-articular Injections in the Treatment of Knee Osteoarthritis in Patients Fifty Years and Older: a Look at Pain and Functional Outcomes at a Single Institution.

TypeinterventionalSponsorThe University of The West IndiesRan2023 to 2025Enrolled160ConditionsKnee OsteoarthritisArmsTriamcinolone, Platelet Rich Plasma
NCT06122116 naterminatednot on this mapstarted 2023, after this paper: background citation

Investigating Orthobiologics After Platelet-Rich Plasma and Photobiomodulation Treatment of Knee Osteoarthritis

TypeinterventionalSponsorMusculoskeletal Injury Rehabilitation Research for Operational ReadinessRan2023 to 2024Enrolled33ConditionsKnee OsteoarthritisArmsPhysical Therapy, Platelet-Rich Plasma Injection, Photobiomodulation Therapy
3 · Its place in the literature

Who cites it

84 citing papers in PubMed, 16 syntheses or guidelines pooled it, 152 citations in OpenAlex.

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  6. Intra-articular hyaluronic acid injections for hip osteoarthritis: a level I systematic review.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2025
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  11. Intra-articular injections of ozone versus hyaluronic acid for knee osteoarthritis: a level I meta-analysis.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2024
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  16. Cell therapies for chondral defects of the talus: a systematic review.Journal of orthopaedic surgery and research · 2022
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24 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Filippo MiglioriniDepartment of Orthopaedics, RWTH Aachen University Medical Centre, University Clinic Aachen, Pauwelsstraße 30, 52074, Aachen, Germany. migliorini.md@gmail.com.ORCID http://orcid.org/0000-0001-7220-1221
Arne DriessenDepartment of Orthopaedics, RWTH Aachen University Medical Centre, University Clinic Aachen, Pauwelsstraße 30, 52074, Aachen, Germany.
Valentin QuackDepartment of Orthopaedics, RWTH Aachen University Medical Centre, University Clinic Aachen, Pauwelsstraße 30, 52074, Aachen, Germany.
Nadja SippelDepartment of Orthopaedics, RWTH Aachen University Medical Centre, University Clinic Aachen, Pauwelsstraße 30, 52074, Aachen, Germany.
Brian CooperDepartment of Orthopaedics, RWTH Aachen University Medical Centre, University Clinic Aachen, Pauwelsstraße 30, 52074, Aachen, Germany.
Yasser El MansyDepartment of Orthopaedics, RWTH Aachen University Medical Centre, University Clinic Aachen, Pauwelsstraße 30, 52074, Aachen, Germany.
Markus TingartDepartment of Orthopaedics, RWTH Aachen University Medical Centre, University Clinic Aachen, Pauwelsstraße 30, 52074, Aachen, Germany.
Jörg EschweilerDepartment of Orthopaedics, RWTH Aachen University Medical Centre, University Clinic Aachen, Pauwelsstraße 30, 52074, Aachen, Germany.
RWTH Aachen University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionRegarding the efficacy of intra-articular injections of platelet-rich plasma, hyaluronic acid and corticosteroids, current evidence is controversial. The superiority of one technique over another is questioned and debates are ongoing. The purpose of the present study was to compare and investigate the efficacy of these intra-articular infiltrations in patients with knee osteoarthritis (OA). A Bayesian network meta-analysis of randomized clinical trials (RCTs) was conducted comparing patient outcomes at 3, 6 and 12-months of follow-up. MATERIALS AND

methodsThis Bayesian network meta-analysis was conducted according to the PRISMA extension statement for reporting systematic reviews incorporating network meta-analyses of health care interventions. All the RCTs comparing the outcomes of two or more intra-articular infiltrations of interest for knee OA were considered for inclusion. The outcomes of interest were the WOMAC and VAS scores. The network meta-analyses were performed using the STATA routine for Bayesian hierarchical random-effects models.

resultsData from 30 RCTs (3463 patients) were collected. At 3-months follow-up, PRP showed the best WOMAC scores, followed by the Placebo, CCS and HA. At 6-months follow-up, PRP showed the best WOMAC scores, followed by HA, CCS and Placebo. At 12-months follow-up, PRP showed the best WOMAC scores, followed by the Placebo, HA and CCS. At 3-months follow-up, the PRP showed the best VAS scores, followed by CCS, HA and Placebo. At 6-months follow-up, PRP showed the best VAS scores, followed by CCS, Placebo and HA. At 12-months follow-up, the PRP showed the best VAS scores, followed by CCS, Placebo and HA.

conclusionIntra-articular injections of PRP demonstrated the best overall outcome compared to steroids, hyaluronic acid and placebo for patients with knee osteoarthrosis at 3, 6 and 12-months follow-up. Among CCS, hyaluronic acid and placebo, no discrepancies were detected. LEVEL OF EVIDENCE: I, Bayesian network meta-analysis of RCTs.

Indexed as

Osteoarthritis, KneeHumansHyaluronic AcidInjections, Intra-ArticularPlatelet-Rich PlasmaSteroidsTreatment OutcomeHyaluronic AcidSteroidsHyaluronic acidInfiltrationKneeOsteoarthritisPRPSteroids

Identifiers

PMID32725315
OpenAlexW3045550930

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.