Evidence map›Paper›PMID 32725230›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2020

Early Insights From Clinical Trials of Typhoid Conjugate Vaccine.

Kathleen M Neuzil, Buddha Basnyat, John D Clemens, Melita A Gordon, Priyanka D Patel, Andrew J Pollard, Mila Shakya, Firdausi Qadri

Abstract read
In one paragraph

Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kathleen M NeuzilUniversity of Maryland School of Medicine, Baltimore, Maryland, USA.
Buddha BasnyatOxford University Clinical Research Unit, Patan Academy of Health Sciences, Kathmandu, Nepal.
John D ClemensInfectious Diseases Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.
Melita A GordonMalawi-Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi.
Priyanka D PatelMalawi-Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi.
Andrew J PollardOxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom.
Mila ShakyaOxford University Clinical Research Unit, Patan Academy of Health Sciences, Kathmandu, Nepal.
Firdausi QadriInfectious Diseases Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Clinical trials of typhoid conjugate vaccine (TCV) are ongoing in 4 countries. Early data confirm safety, tolerability, and immunogenicity of typhoid conjugate vaccine, and early efficacy results are promising. These data support World Health Organization recommendations and planned country introductions. Forthcoming trial data will continue to inform programmatic use of typhoid conjugate vaccine.

Indexed as

Typhoid FeverTyphoid-Paratyphoid VaccinesHumansSalmonella typhiVaccines, ConjugateWorld Health OrganizationTyphoid-Paratyphoid VaccinesVaccines, Conjugateclinical trialsconjugate vaccinetyphoidTyVAC

Identifiers

PMID32725230
PMCPMC7388715

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.