Observational studyInvestigative ophthalmology & visual science2020
Retinal Neurovascular Impairment in Patients with Essential Hypertension: An Optical Coherence Tomography Angiography Study.
Observational study in Investigative ophthalmology & visual science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- The Application of Optical Coherence Tomography Angiography in Systemic Hypertension: A Meta-Analysis.Frontiers in medicine · 2021Pooled it
- Influence of Cardiometabolic Disease on Macular Structural Changes After Uncomplicated Phacoemulsification.Journal of clinical medicine · 2026Article
- Retinal Vascular Features and Risk of Colorectal Cancer Incidence and Mortality: A Population-Based Cohort Study.Ophthalmology and therapy · 2026Article
- Retinal biological age correlates with bone mineral density and fracture risk score and predicts incident osteoporosis.PLOS digital health · 2026Article
- Retinal Dysfunction in Hypertensive Patients with Atherosclerotic Plaque Detected by Carotid Doppler Ultrasound: An Optical Coherence Tomography Angiography Assessment.Life (Basel, Switzerland) · 2026Article
- Analysis of factors influencing retinal thickness in chronic obstructive pulmonary disease and hypertension: a cross-sectional study in a community-dwelling middle-aged and elderly population.Frontiers in medicine · 2026Article
- Evaluating the effect of systemic hypertension on retinal, optic nerve head microvasculature and field of vision using optical coherence tomography angiography and visual field analyzer.BMC ophthalmology · 2025Observational
- Quantitative analysis of macular and optic disc microvascular parameters in patients with immunoglobulin A nephropathy using optical coherence tomography angiography.Quantitative imaging in medicine and surgery · 2025Article
- Control of blood pressure and blood glucose levels has important clinical significance to the retina.BMC ophthalmology · 2025Article
- Retinal optical coherence tomography angiography (OCTA) biomarkers of cardiovascular disease: a review article.Eye (London, England) · 2025Review
- Retinal Imaging as a Window into Cardiovascular Health: Towards Harnessing Retinal Analytics for Precision Cardiovascular Medicine.Journal of cardiovascular development and disease · 2025Review
- Structure-Function Associations Between Quantitative Contrast Sensitivity Function And Peripapillary Optical Coherence Tomography Angiography in Diabetic Retinopathy.Investigative ophthalmology & visual science · 2025Article
- The role of peripapillary vessel density and retinal nerve fiber layer thickness in diagnosing and monitoring myopic glaucoma.Frontiers in medicine · 2025Article
- Retinal Microangiopathy as a Marker of Coronary Atherosclerotic Heart Disease.International journal of general medicine · 2025Review
- Investigation of early-stage cardiovascular-kidney-metabolic syndrome on retinal structure and function evaluated by optical coherence tomography angiography.Frontiers in medicine · 2025Article
- Observational
- Retinal Imaging-Based Oculomics: Artificial Intelligence as a Tool in the Diagnosis of Cardiovascular and Metabolic Diseases.Biomedicines · 2024Review
- The Eye as the Window to the Heart: Optical Coherence Tomography Angiography Biomarkers as Indicators of Cardiovascular Disease.Journal of clinical medicine · 2024Review
- Intraocular pressure increases the rate of macular vessel density loss in glaucoma.The British journal of ophthalmology · 2024Observational
- Changes in peripapillary microvasculature in patients with type 2 diabetes patients: effect of systemic hypertension.Scientific reports · 2023Article
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: To investigate retinal neurovascular structural changes in patients with essential hypertension. Methods: This observational cross-sectional study consisted of 199 right eyes from 169 nondiabetic essential hypertensive patients, divided into groups as follows: group A, 113 patients with hypertensive retinopathy (HTNR); group B, 56 patients without HTNR; and a control group of 30 healthy subjects. Peripapillary retinal nerve fiber layer (RNFL), radial peripapillary segmented (RPC), ganglion cell-inner plexiform layer (GC-IPL), and superficial (SVP) and deep (DVP) vascular plexus density at the macula (6 × 6 mm2) were measured by optical coherence tomography angiography (OCTA). Results: DVP density was significantly reduced in groups A and B compared to the control group (group A DVP, P = 0.001; group B DVP P = 0.002). GC-IPL, RNFL thickness, and RPC and SVP density in group A were significantly decreased compared to the control group or group B (all P < 0.05). In hypertensive patients, GC-IPL and RNFL thickness were negatively correlated with severity of HTNR (GC-IPL, r = -0.331, P < 0.001; RNFL, r = -0.583, P < 0.001) and level of home blood pressure monitoring (HBPM) (GC-IPL, r = -0.160, P = 0.050; RNFL, r = -0.282, P = 0.001) and were positively correlated with SVP (GC-IPL, r = 0.267, P = 0.002; RNFL, r = 0.361, P < 0.001) and RPC density (GC-IPL, r = 0.298, P < 0.001; RNFL, r = 0.663, P < 0.001). Among subjects with grade 2 or 3 retinopathy, the superior RNFL was significantly thinner in patients with high HBPM level than in those with normal HBPM level (grade 2, P = 0.016; grade 3, P = 0.006). Conclusions: Reduction of retinal vessel density and RNFL thickness is observed in patients with HTNR and is inversely associated with level of HBPM.
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