Observational studyThe Journal of clinical endocrinology and metabolism2020
Pancreatic Steatosis Associates With Impaired Insulin Secretion in Genetically Predisposed Individuals.
Observational study in The Journal of clinical endocrinology and metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.
- Burden of Intrapancreatic Fat Deposition in Type 2 Diabetes and the Role of Obesity: A Systematic Review and Meta-Analysis.Current obesity reports · 2026Pooled it
- Association of pre-pregnancy body mass index and first-trimester remnant cholesterol level with risk of large for gestational age.Journal of global health · 2026Article
- Conceptual framework and expert guidance on intrapancreatic fat deposition: the Melbourne consensus.Nature reviews. Gastroenterology & hepatology · 2026Review
- Ectopic fat distribution and its correlation with insulin resistance indices in non-obese individuals with type 2 diabetes.Acta diabetologica · 2026Article
- Explainable AI-based analysis of human pancreas sections identifies traits of type 2 diabetes.Nature communications · 2026Article
- Cardiometabolic risk status modifies the associations between remnant cholesterol with incident diabetes: evidence from two East Asian cohorts.Frontiers in nutrition · 2026Article
- Interaction between fatty pancreas disease and genetically predicted glucose-dependent insulinotropic polypeptide on incident type 2 diabetes: evidence from the UK Biobank.Frontiers in endocrinology · 2026Article
- Association of pancreas fat fraction with adverse kidney and cardiovascular outcomes.Clinical kidney journal · 2025Article
- Sex-specific associations of intrapancreatic fat deposition with incident type 2 diabetes.Communications medicine · 2025Article
- Mild Mitochondrial Uncoupling for True Ectopic Lipid Disposal.International journal of molecular sciences · 2025Review
- The Clock is Still Ticking: Tirzepatide and the Myth of Halting the Natural History of Type 2 Diabetes.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2025Article
- The mediating role of inflammation-related indicators in the association of remnant cholesterol with gestational diabetes mellitus.Journal of global health · 2025Article
- Accurate screening of patients with diabetes based on physical examination: pancreas imaging features from chest CT and laboratory data.Frontiers in endocrinology · 2025Article
- Nonlinear association between remnant cholesterol and reversion from impaired fasting glucose to normoglycemia: a multicenter cohort study.Lipids in health and disease · 2024Article
- Diabetes Mellitus, Energy Metabolism, and COVID-19.Endocrine reviews · 2024Review
- Sexual dysfunction in patients with diabetes: association between remnant cholesterol and erectile dysfunction.Lipids in health and disease · 2024Article
- Evidence for a causal link between intra-pancreatic fat deposition and pancreatic cancer: A prospective cohort and Mendelian randomization study.Cell reports. Medicine · 2024Observational
- CT Quantitation and Prediction of the Risk of Type 2 Diabetes Mellitus in Non-Obese Patients with Pancreatic Fatty Infiltration.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Article
- Childhood adiposity and novel subtypes of adult-onset diabetes: a Mendelian randomisation and genome-wide genetic correlation study.Diabetologia · 2023Article
- Fatty Pancreas: Linking Pancreas Pathophysiology to Nonalcoholic Fatty Liver Disease.Journal of clinical and translational hepatology · 2022Review
Corrections and comments
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Authors and funding
16 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextPancreatic steatosis leading to beta-cell failure might be involved in type 2 diabetes (T2D) pathogenesis.
objectiveWe hypothesized that the genetic background modulates the effect of pancreatic fat on beta-cell function and investigated genotype × pancreatic fat interactions on insulin secretion.
designTwo observational studies.
settingUniversity hospital. PATIENTS OR
participantsA total of 360 nondiabetic individuals with elevated risk for T2D (Tuebingen Family Study [TUEF]), and 64 patients undergoing pancreatectomy (Pancreas Biobank [PB], HbA1c <9%, no insulin therapy).
main outcome measuresInsulin secretion calculated from 5-point oral glucose tolerance test (TUEF) and fasting blood collection before surgery (PB). A genome-wide polygenic score for T2D was computed from 484,788 genotyped variants. The interaction of magnetic resonance imaging-measured and histologically quantified pancreatic fat with the polygenic score was investigated. Partitioned risk scores using genome-wide significant variants were also computed to gain insight into potential mechanisms.
resultsPancreatic steatosis interacted with genome-wide polygenic score on insulin secretion (P = 0.003), which was similar in the replication cohort with histological measurements (P = 0.03). There was a negative association between pancreatic fat and insulin secretion in participants with high genetic risk, whereas individuals with low genetic risk showed a positive correlation between pancreatic fat and insulin secretion. Consistent interactions were found with insulin resistance-specific and a liver/lipid-specific polygenic scores.
conclusionsThe associations suggest that pancreatic steatosis only impairs beta-cell function in subjects at high genetic risk for diabetes. Genetically determined insulin resistance specifically renders pancreatic fat deleterious for insulin secretion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.