ArticleJournal of experimental botany2020
Inducible biosynthesis and immune function of the systemic acquired resistance inducer N-hydroxypipecolic acid in monocotyledonous and dicotyledonous plants.
Article in Journal of experimental botany, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 60 citations in OpenAlex.
- The role of induced resistance in mitigating postharvest fungal diseases in fruits and vegetables.Journal of advanced research · 2026Review
- Antarctic moss fairy rings serve as reservoirs for plant growth-promoting bacteria.BMC plant biology · 2026Article
- N-hydroxy-pipecolic acid-mediated signal transduction and resistance requires DAWDLE.Plant physiology · 2025Article
- A root-based N-hydroxypipecolic acid standby circuit to direct immunity and growth of Arabidopsis shoots.Nature plants · 2025Article
- A Simplified and Integrated View of Disease Control in Varietal Mixtures Using the Phytobiome Framework.Plant, cell & environment · 2025Review
- Distinct Infection Mechanisms ofLife (Basel, Switzerland) · 2025Article
- All Roads Lead to Rome: Pathways to Engineering Disease Resistance in Plants.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Phosphoproteomic analysis uncovers phosphorylated proteins in response to salicylic acid and N-hydroxypipecolic acid in Arabidopsis.Molecular biology reports · 2024Article
- A NAC triad modulates plant immunity by negatively regulating N-hydroxy pipecolic acid biosynthesis.Nature communications · 2024Article
- A bird's-eye view: exploration of the flavin-containing monooxygenase superfamily in common wheat.Frontiers in plant science · 2024Article
- Induced Resistance Mechanism of Bacillus velezensis S3-1 Against Pepper Wilt.Current microbiology · 2023Article
- Regulation of Salicylic Acid and N-Hydroxy-Pipecolic Acid in Systemic Acquired Resistance.The plant pathology journal · 2023Review
- Chemical priming of plant defense responses to pathogen attacks.Frontiers in plant science · 2023Review
- N-hydroxypipecolic acid primes plants for enhanced microbial pattern-induced responses.Frontiers in plant science · 2023Article
- Analysis of the apoplast fluid proteome during the induction of systemic acquired resistance inPeerJ · 2023Article
- N-Hydroxy pipecolic acid methyl ester is involved in Arabidopsis immunity.Journal of experimental botany · 2023Article
- Lipid transfer proteins involved in plant-pathogen interactions and their molecular mechanisms.Molecular plant pathology · 2022Review
- Salicylic Acid andFrontiers in plant science · 2022Review
- Molecular mechanisms underlying multi-level defense responses of horticultural crops to fungal pathogens.Horticulture research · 2022Article
- Molecular mechanisms of resistance toFrontiers in plant science · 2022Article
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent work has provided evidence for the occurrence of N-hydroxypipecolic acid (NHP) in Arabidopsis thaliana, characterized its pathogen-inducible biosynthesis by a three-step metabolic sequence from l-lysine, and established a central role for NHP in the regulation of systemic acquired resistance. Here, we show that NHP is biosynthesized in several other plant species in response to microbial attack, generally together with its direct metabolic precursor pipecolic acid and the phenolic immune signal salicylic acid. For example, NHP accumulates locally in inoculated leaves and systemically in distant leaves of cucumber in response to Pseudomonas syringae attack, in Pseudomonas-challenged tobacco and soybean leaves, in tomato inoculated with the oomycete Phytophthora infestans, in leaves of the monocot Brachypodium distachyon infected with bacterial (Xanthomonas translucens) and fungal (Magnaporthe oryzae) pathogens, and in M. oryzae-inoculated barley. Notably, resistance assays indicate that NHP acts as a potent inducer of acquired resistance to bacterial and fungal infection in distinct monocotyledonous and dicotyledonous species. Pronounced systemic accumulation of NHP in leaf phloem sap of locally inoculated cucumber supports a function for NHP as a phloem-mobile immune signal. Our study thus generalizes the existence and function of an NHP resistance pathway in plant systemic acquired resistance.
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