Evidence map›Paper›PMID 32725102›Full record

Trial reportRevista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)

N-acetylcysteine as an adjunctive treatment for smoking cessation: a randomized clinical trial.

Regina C B R Machado, Heber O Vargas, Marcela M Baracat, Mariana R Urbano, Waldiceu A Verri, Mauro Porcu, Sandra O V Nunes

2 registry-linked trialsOpen access · diamondAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999). The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02420418 naunknown statusnot on this map

The Effect of N- Acetylcysteine on Inflammatory and Oxidative Stress Biomarkers in Patients With Tobacco Use Disorders and Bipolar Disorders ..

TypeinterventionalSponsorUniversidade Estadual de LondrinaRan2015 to 2017Enrolled72ConditionsBipolar DisorderArmsN-acetyl-cysteine (NAC), Placebo
NCT05903014 phase4completednot on this map

Effectiveness of N-Acetylcysteine in Motivational Enhancement Therapy for Nicotine Addiction: Study on the Dopaminergic Pathways, Changes in Functional Connectivity of fMRI Bold, and Changes in Smoking Abstinence

TypeinterventionalSponsorIndonesia UniversityRan2023 to 2023Enrolled90ConditionsNicotine Dependence, Nicotine AddictionArmsn-acetylcysteine, Motivational Enhancement Therapy
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 20 citations in OpenAlex.

  1. Trial
  2. Article
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  4. Article
  5. Review
  6. Article
  7. Review
  8. Antioxidants (Basel, Switzerland) · 2021
    Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Regina C B R MachadoCentro de Referência de Abordagem e Tratamento do Tabagismo, Hospital Universitário, Universidade Estadual de Londrina (UEL), Londrina, PR, Brazil.ORCID http://orcid.org/0000-0001-5531-7345
Heber O VargasCentro de Referência de Abordagem e Tratamento do Tabagismo, Hospital Universitário, Universidade Estadual de Londrina (UEL), Londrina, PR, Brazil.
Marcela M BaracatPrograma de Pós-Graduação em Ciências da Saúde, Centro de Ciências da Saúde (CCS), UEL, Londrina, PR, Brazil.ORCID http://orcid.org/0000-0002-7109-7191
Mariana R UrbanoPrograma de Pós-Graduação em Ciências da Saúde, Centro de Ciências da Saúde (CCS), UEL, Londrina, PR, Brazil.ORCID http://orcid.org/0000-0002-5411-5554
Waldiceu A VerriPrograma de Pós-Graduação em Ciências da Saúde, Centro de Ciências da Saúde (CCS), UEL, Londrina, PR, Brazil.ORCID http://orcid.org/0000-0003-2756-9283
Mauro PorcuCentro de Referência de Abordagem e Tratamento do Tabagismo, Hospital Universitário, Universidade Estadual de Londrina (UEL), Londrina, PR, Brazil.ORCID http://orcid.org/0000-0002-5028-1811
Sandra O V NunesCentro de Referência de Abordagem e Tratamento do Tabagismo, Hospital Universitário, Universidade Estadual de Londrina (UEL), Londrina, PR, Brazil.ORCID http://orcid.org/0000-0003-4851-6121
Universidade Estadual de Londrina · BRCentro de Estudos em Psicologia da Saúde · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis randomized controlled trial examined the efficacy and safety of N-acetylcysteine as an adjunctive treatment for smoking cessation.

methodsHeavy smokers were recruited from smoking cessation treatment for this 12- week randomized controlled trial. Eligible tobacco use disorder outpatients (n=34) were randomized to N-acetylcysteine or placebo plus first-line treatment. Abstinence was verified by exhaled carbon monoxide (COexh). The assessment scales included the Fagerström Test for Nicotine Dependence, the Hamilton Depression Rating Scale, the Hamilton Anxiety Rating Scale, the Minnesota Nicotine Withdrawal Scale, and the Medication Adherence Rating Scale. We also assessed anthropometrics, blood pressure, lipid profile, and soluble tumor necrosis factor receptor (sTNF-R) levels 1 and 2.

resultsFirst-line treatment for smoking cessation plus adjunctive N-acetylcysteine or placebo significantly reduced COexh (p < 0.01). In the N-acetylcysteine group, no significant changes were found in nicotine withdrawal symptoms, depressive and anxiety symptoms, anthropometric measures, blood pressure, or glucose compared to placebo. However, there was a significant reduction in sTNF-R2 levels between baseline and week 12 in the N-acetylcysteine group.

conclusionsThese findings highlight the need to associate N-acetylcysteine with first-line treatment for smoking cessation, since combined treatment may affect inflammation and metabolism components. CLINICAL

trial registrationNCT02420418.

Indexed as

Smoking CessationTobacco Use DisorderAcetylcysteineDouble-Blind MethodHumansNicotineTreatment OutcomeAcetylcysteineNicotine

Identifiers

PMID32725102
PMCPMC7524413
OpenAlexW3046888692

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.