Evidence map›Paper›PMID 32724884›Full record

ArticleAnnals of gastroenterological surgery2020

Frailty is an independent risk factor for recurrence and mortality following curative resection of stage I-III colorectal cancer.

Kosuke Mima, Nobutomo Miyanari, Atsushi Morito, Shinsei Yumoto, Takashi Matsumoto, Keisuke Kosumi, Mitsuhiro Inoue, Takao Mizumoto, Tatsuo Kubota, Hideo Baba

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In one paragraph

Article in Annals of gastroenterological surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 6 syntheses or guidelines pooled it.

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  15. Clinical Frailty Scale predicts overall survival after colon cancer surgery in people aged 80 years and older: A prospective multicentre observational study.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kosuke MimaDepartment of Surgery National Hospital Organization Kumamoto Medical Center Kumamoto Japan.ORCID https://orcid.org/0000-0002-4385-4984
Nobutomo MiyanariDepartment of Surgery National Hospital Organization Kumamoto Medical Center Kumamoto Japan.
Atsushi MoritoDepartment of Surgery National Hospital Organization Kumamoto Medical Center Kumamoto Japan.
Shinsei YumotoDepartment of Surgery National Hospital Organization Kumamoto Medical Center Kumamoto Japan.
Takashi MatsumotoDepartment of Surgery National Hospital Organization Kumamoto Medical Center Kumamoto Japan.
Keisuke KosumiDepartment of Surgery National Hospital Organization Kumamoto Medical Center Kumamoto Japan.
Mitsuhiro InoueDepartment of Surgery National Hospital Organization Kumamoto Medical Center Kumamoto Japan.
Takao MizumotoDepartment of Surgery National Hospital Organization Kumamoto Medical Center Kumamoto Japan.
Tatsuo KubotaDepartment of Surgery National Hospital Organization Kumamoto Medical Center Kumamoto Japan.
Hideo BabaDepartment of Gastroenterological Surgery Graduate School of Medical Science Kumamoto University Kumamoto Japan.ORCID https://orcid.org/0000-0002-0082-7601

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimWith population aging, the number of frail patients with colorectal cancer has increased. The Clinical Frailty Scale (CFS) is a validated tool for assessing frailty, and higher scores indicate worse clinical outcomes following cardiovascular procedures. This retrospective study aimed to examine preoperative frailty in relation to recurrence and mortality following curative resection of colorectal cancer.

methodsWe retrospectively analyzed data for 729 consecutive patients undergoing curative resection of stage I-stage III colon and rectal adenocarcinoma between January 2009 and December 2016. Frailty was assessed using the CFS: 1 (very fit) to 9 (terminally ill), and frailty was defined as CFS ≥ 4. Recurrence-free survival (RFS) and overall survival (OS) were compared between frail and nonfrail patients. Cox proportional hazards model was used to calculate hazard ratios (HRs), controlling for potential confounders.

resultsCFS score was negatively correlated with the Barthel index of activities of daily living (Spearman's ρ = -0.83). Of the 729 patients, 253 (35%) were frail. In multivariable analyses adjusting for potential confounders including age and disease stage, frailty was independently associated with shorter RFS (multivariable HR: 1.70, 95% confidence interval: 1.25-2.31,

conclusionPreoperative frailty was independently associated with shorter RFS and OS following resection of nonmetastatic colorectal cancer, regardless of age and disease stage. Further trials are needed to establish treatment strategies for frail patients with colorectal cancer.

Indexed as

elderlygeriatricsgerontologymorbidityneoplasm

Identifiers

PMID32724884
PMCPMC7382441

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.