Evidence map›Paper›PMID 32724453›Full record

ArticleTheranostics2020

RNA-binding protein NONO contributes to cancer cell growth and confers drug resistance as a theranostic target in TNBC.

Seong-Jin Kim, Jin-Sung Ju, Myoung-Hee Kang, Ji Won Eun, Young Ha Kim, Prahlad V Raninga, Kum Kum Khanna, Balázs Győrffy, Chan-Gi Pack, Hee-Dong Han and 6 more

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
4.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 74 citations in OpenAlex.

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  19. The mExperimental & molecular medicine · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 3 countries.

Seong-Jin KimDepartment of Convergence Medicine, University of Ulsan College of Medicine, Seoul, Korea.
Jin-Sung JuDepartment of Convergence Medicine, University of Ulsan College of Medicine, Seoul, Korea.
Myoung-Hee KangAsan Institute for Life Sciences, Asan Medical Center, Seoul, Korea.
Ji Won EunDepartment of Immunology School of Medicine, Konkuk University, Chungju, South Korea.
Young Ha KimAsan Institute for Life Sciences, Asan Medical Center, Seoul, Korea.
Prahlad V RaningaQIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Kum Kum KhannaQIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Balázs GyőrffyMTA TTK Lendület Cancer Biomarker Research Group; Institute of Enzymology; Semmelweis University 2nd Dept. of Pediatrics, Budapest, Hungary.
Chan-Gi PackDepartment of Convergence Medicine, University of Ulsan College of Medicine, Seoul, Korea.
Hee-Dong HanDepartment of Immunology School of Medicine, Konkuk University, Chungju, South Korea.
Hee Jin LeeDepartment of Pathology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
Gyungyub GongDepartment of Pathology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
Yong ShinDepartment of Convergence Medicine, University of Ulsan College of Medicine, Seoul, Korea.
Gordon B MillsDepartment of Cell, Development and Cancer Biology, Oregon Health & Science University, Portland, OR, USA.
Seong-Il EyunDepartment of Life Science, Chung-Ang University, Seoul, Korea.
Yun-Yong ParkDepartment of Convergence Medicine, University of Ulsan College of Medicine, Seoul, Korea.
Asan Medical Center · KRKonkuk University · KRQIMR Berghofer Medical Research Institute · AUUlsan College · KRUniversity of Ulsan · KRChung-Ang University · KROregon Health & Science University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Breast cancer (BC) is one of the most common cancers in women. TNBC (Triple-negative breast cancer) has limited treatment options and still lacks viable molecular targets, leading to poor outcomes. Recently, RNA-binding proteins (RBPs) have been shown to play crucial roles in human cancers, including BC, by modulating a number of oncogenic phenotypes. This suggests that RBPs represent potential molecular targets for BC therapy.

Indexed as

Antineoplastic Combined Chemotherapy ProtocolsApoptosisCell Line, TumorCell MovementCell ProliferationDNA-Binding ProteinsDrug CarriersDrug Resistance, NeoplasmDrug Screening Assays, AntitumorFemaleGene Expression Regulation, NeoplasticGenomicsHumansNanoparticlesPrecision MedicineRNA-Binding ProteinsDNA-Binding ProteinsDrug CarriersNONO protein, humanRNA-Binding ProteinsSTAT3 protein, humanSTAT3 Transcription FactorAuranofin.NONORBPSTAT3TNBC

Identifiers

PMID32724453
PMCPMC7381744
OpenAlexW3040304626

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.