ArticleOncology letters2020
Function of miR-200a in proliferation and apoptosis of non-small cell lung cancer cells.
Article in Oncology letters, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 14 citations in OpenAlex.
- The Role of MicroRNAs Implicated in the Regulation of PI3K/AKT and Focal Adhesion Signaling Pathways in Chronic Obstructive Pulmonary Disease.Biochemical genetics · 2026Article
- Urinary biomarkers for lung cancer detection.The journal of liquid biopsy · 2026Article
- Blood-Based miRNA Panels for Timely Detection of Non-Small-Cell Lung Cancer: From Biomarker Discovery to Clinical Translation.International journal of molecular sciences · 2025Review
- Functional analysis of cancer-associated germline risk variants.Nature genetics · 2025Article
- Expression Pattern Study of miR-200a and XIAP Gene in the Non-small Cell Lung Cancer Patients’ BloodIranian biomedical journal · 2025Article
- A Novel Defined PANoptosis-Related miRNA Signature for Predicting the Prognosis and Immune Characteristics in Clear Cell Renal Cell Carcinoma: A miRNA Signature for the Prognosis of ccRCC.International journal of molecular sciences · 2023Article
- MiRNA and Potential Prognostic Value in Non-Smoking Females with Lung Adenocarcinoma by High-Throughput Sequencing.International journal of general medicine · 2023Article
- The role of miR-200 family in the regulation of hallmarks of cancer.Frontiers in oncology · 2022Review
- Cell Behavior of Non-Small Cell Lung Cancer Is at EGFR and MicroRNAs Hands.International journal of molecular sciences · 2021Review
- Identification of Prognostic Gene Biomarkers in Non-Small Cell Lung Cancer Progression by Integrated Bioinformatics Analysis.Biology · 2021Article
- P76RBE silencing inhibits ovarian cancer cell proliferation, migration, and invasion via suppressing the integrin β1/NF-κB pathway.Cell cycle (Georgetown, Tex.) · 2021Article
- Long Non-Coding RNA H19 Regulates Glioma Cell Growth and MetastasisFrontiers in oncology · 2021Article
- miR-1225-5p inhibits non-small cell lung cancer cell proliferation, migration and invasion, and may be a prognostic biomarker.Experimental and therapeutic medicine · 2020Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lung cancer is the most prevalent type of cancer worldwide and is the leading cause of cancer-associated cases of mortality in the USA and China. Non-small cell lung cancer (NSCLC) accounts for 80-85% of lung cancer cases. microRNAs (miRs) serve multiple roles in the pathogenesis of lung cancer. The current study investigated the lower level of miR-200a in tumor tissues compared with healthy tissue. Overexpression of miR-200a inhibited NSCLC cell proliferation and promoted apoptosis. miR-200a was identified to target Rhophilin Rho GTPase binding protein 2 (RHPN2) and higher levels of RHPN2 were observed in tumor tissues compared with adjacent normal tissues. The current study proposes that miR-200a exhibits a tumor suppressive role in NSCLC and suggests that miR-200a could target RHPN2.
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