Evidence map›Paper›PMID 32724184›Full record

ArticleScientific reports2020

Focal dynamic thermal imaging for label-free high-resolution characterization of materials and tissue heterogeneity.

Christine M O'Brien, Hongyu Meng, Leonid Shmuylovich, Julia Carpenter, Praneeth Gogineni, Haini Zhang, Kevin Bishop, Suman B Mondal, Gail P Sudlow, Cheryl Bethea and 2 more

Abstract readEvaluation Study
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Christine M O'Brien *Department of Radiology, Washington University School of Medicine, 4515 McKinley Ave., Couch Biomedical Research Building, St. Louis, MO, 63110, USA.
Hongyu Meng *Department of Radiology, Washington University School of Medicine, 4515 McKinley Ave., Couch Biomedical Research Building, St. Louis, MO, 63110, USA.
Leonid Shmuylovich *Department of Radiology, Washington University School of Medicine, 4515 McKinley Ave., Couch Biomedical Research Building, St. Louis, MO, 63110, USA.
Julia CarpenterDepartment of Radiology, Washington University School of Medicine, 4515 McKinley Ave., Couch Biomedical Research Building, St. Louis, MO, 63110, USA.
Praneeth GogineniDepartment of Radiology, Washington University School of Medicine, 4515 McKinley Ave., Couch Biomedical Research Building, St. Louis, MO, 63110, USA.
Haini ZhangDepartment of Radiology, Washington University School of Medicine, 4515 McKinley Ave., Couch Biomedical Research Building, St. Louis, MO, 63110, USA.
Kevin BishopDepartment of Radiology, Washington University School of Medicine, 4515 McKinley Ave., Couch Biomedical Research Building, St. Louis, MO, 63110, USA.
Suman B MondalDepartment of Radiology, Washington University School of Medicine, 4515 McKinley Ave., Couch Biomedical Research Building, St. Louis, MO, 63110, USA.
Gail P SudlowDepartment of Radiology, Washington University School of Medicine, 4515 McKinley Ave., Couch Biomedical Research Building, St. Louis, MO, 63110, USA.
Cheryl BetheaQuantum Technology Consultants, Inc., 8 Grist Mill Lane, Franklin Park, NJ, 08823, USA.
Clyde BetheaQuantum Technology Consultants, Inc., 8 Grist Mill Lane, Franklin Park, NJ, 08823, USA.
Samuel AchilefuDepartment of Radiology, Washington University School of Medicine, 4515 McKinley Ave., Couch Biomedical Research Building, St. Louis, MO, 63110, USA. achilefu@wustl.edu.

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI TIMOTHY J. EBERLEIN · 2001 to 2026
$128.0M
WU-MDACC Inter-Institutional Molecular Imaging CenterP50CA094056 · NCI · WASHINGTON UNIVERSITY · PI KOPAN, RAPHAEL · 2002 to 2016
$26.3M
Project 2 - Radiation-Induced Treatment of Multiple Myeloma using NanoparticlesU54CA199092 · NCI · WASHINGTON UNIVERSITY · PI ACHILEFU, SAMUEL · 2015 to 2019
$11.5M
DEVELOPMENT OF GOGGLE SYSTEM FOR FLUORESCENCE IMAGE-GUIDED SURGERYR01CA171651 · NCI · WASHINGTON UNIVERSITY · PI ACHILEFU, SAMUEL · 2013 to 2017
$2.8M
Training OPportunities in Translational Imaging Education and Research (TOP-TIER)T32EB021955 · NIBIB · WASHINGTON UNIVERSITY · PI Hongyu An, Joseph Edward Ippolito · 2017 to 2026
$2.4M
NANOPHOTOSENSITIZERS FOR REGENERATIVE PHOTOTHERAPY OF TUMORSR01EB021048 · NIBIB · WASHINGTON UNIVERSITY · PI ACHILEFU, SAMUEL · 2015 to 2020
$2.3M
IVIS Spectrum CT Preclinical In Vivo Imaging SystemS10OD027042 · OD · WASHINGTON UNIVERSITY · PI ACHILEFU, SAMUEL · 2019 to 2019
$599k
Multispectral Optoacoustic Tomography (MSOT) SystemS10OD025264 · OD · WASHINGTON UNIVERSITY · PI ACHILEFU, SAMUEL · 2018 to 2018
$544k
FLUORESCENCE MOLECULAR TOMOGRAPHY SYSTEMS10OD020129 · OD · WASHINGTON UNIVERSITY · PI ACHILEFU, SAMUEL · 2015 to 2015
$330k
FLUORESCENCE LIFETIME IMAGING MICROSCOPY SYSTEMS10OD016237 · OD · WASHINGTON UNIVERSITY · PI ACHILEFU, SAMUEL · 2014 to 2014
$267k
NCI NIH HHS P30 CA091842NCI NIH HHS P50 CA094056NCI NIH HHS R01 CA171651NCI NIH HHS U54 CA199092NIBIB NIH HHS R01 EB021048NIBIB NIH HHS T32 EB021955NIH HHS R01 CA171651NIH HHS S10 OD016237NIH HHS S10 OD020129NIH HHS S10 OD025264NIH HHS S10 OD027042
6 · The paper itself

Abstract

Evolution from static to dynamic label-free thermal imaging has improved bulk tissue characterization, but fails to capture subtle thermal properties in heterogeneous systems. Here, we report a label-free, high speed, and high-resolution platform technology, focal dynamic thermal imaging (FDTI), for delineating material patterns and tissue heterogeneity. Stimulation of focal regions of thermally responsive systems with a narrow beam, low power, and low cost 405 nm laser perturbs the thermal equilibrium. Capturing the dynamic response of 3D printed phantoms, ex vivo biological tissue, and in vivo mouse and rat models of cancer with a thermal camera reveals material heterogeneity and delineates diseased from healthy tissue. The intuitive and non-contact FDTI method allows for rapid interrogation of suspicious lesions and longitudinal changes in tissue heterogeneity with high-resolution and large field of view. Portable FDTI holds promise as a clinical tool for capturing subtle differences in heterogeneity between malignant, benign, and inflamed tissue.

Indexed as

Phantoms, ImagingAnimalsDiagnostic ImagingFemaleHumansMiceMice, Inbred BALB CNeoplasmsRatsRats, Sprague-Dawley

Identifiers

PMID32724184
PMCPMC7387563

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.