Evidence map›Paper›PMID 32724101›Full record

ArticleNature communications2020

Neonatal genetics of gene expression reveal potential origins of autoimmune and allergic disease risk.

Qin Qin Huang, Howard H F Tang, Shu Mei Teo, Danny Mok, Scott C Ritchie, Artika P Nath, Marta Brozynska, Agus Salim, Andrew Bakshi, Barbara J Holt and 5 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 42 citations in OpenAlex.

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  15. Frontiers in immunology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 4 countries.

Qin Qin HuangCambridge Baker Systems Genomics Initiative, Baker Heart and Diabetes Institute, Melbourne, VIC, 3004, Australia. qh1@sanger.ac.uk.ORCID http://orcid.org/0000-0003-3073-717X
Howard H F TangCambridge Baker Systems Genomics Initiative, Baker Heart and Diabetes Institute, Melbourne, VIC, 3004, Australia.
Shu Mei TeoCambridge Baker Systems Genomics Initiative, Baker Heart and Diabetes Institute, Melbourne, VIC, 3004, Australia.
Danny MokTelethon Kids Institute, The University of Western Australia, Perth, WA, 6009, Australia.
Scott C RitchieCambridge Baker Systems Genomics Initiative, Baker Heart and Diabetes Institute, Melbourne, VIC, 3004, Australia.ORCID http://orcid.org/0000-0002-8454-9548
Artika P NathCambridge Baker Systems Genomics Initiative, Baker Heart and Diabetes Institute, Melbourne, VIC, 3004, Australia.
Marta BrozynskaCambridge Baker Systems Genomics Initiative, Baker Heart and Diabetes Institute, Melbourne, VIC, 3004, Australia.
Agus SalimBaker Heart and Diabetes Institute, Melbourne, VIC, 3004, Australia.
Andrew BakshiMonash Biomedicine Discovery Institute, Prostate Cancer Research Group, Department of Anatomy and Developmental Biology, Monash University, Clayton, VIC, 3800, Australia.ORCID http://orcid.org/0000-0001-5650-7036
Barbara J HoltTelethon Kids Institute, The University of Western Australia, Perth, WA, 6009, Australia.
Chiea Chuen KhorHuman Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, 138672, Singapore.ORCID http://orcid.org/0000-0002-1128-4729
Peter D SlyChild Health Research Centre, The University of Queensland, Brisbane, QLD, 4101, Australia.ORCID http://orcid.org/0000-0001-6305-2201
Patrick G HoltTelethon Kids Institute, The University of Western Australia, Perth, WA, 6009, Australia.ORCID http://orcid.org/0000-0003-1193-0935
Kathryn E HoltDepartment of Infectious Diseases, Central Clinical School, Monash University, Melbourne, VIC, 3004, Australia.ORCID http://orcid.org/0000-0003-3949-2471
Michael InouyeCambridge Baker Systems Genomics Initiative, Baker Heart and Diabetes Institute, Melbourne, VIC, 3004, Australia. minouye@baker.edu.au.ORCID http://orcid.org/0000-0001-9413-6520
Baker Heart and Diabetes Institute · AUThe Kids Research Institute Australia · AUThe University of Queensland · AUAgency for Science, Technology and Research · SGLondon School of Hygiene & Tropical Medicine · GBMonash University · AUTuring Institute · GB

Funding

British Heart Foundation RG/13/13/30194British Heart Foundation RG/18/13/33946Chief Scientist OfficeDepartment of HealthMedical Research Council MR/L003120/1Wellcome Trust
6 · The paper itself

Abstract

Chronic immune-mediated diseases of adulthood often originate in early childhood. To investigate genetic associations between neonatal immunity and disease, we map expression quantitative trait loci (eQTLs) in resting myeloid cells and CD4

Indexed as

Autoimmune DiseasesButyrophilinsCathepsin HCD4-Positive T-LymphocytesChildChild DevelopmentChild, PreschoolDatasets as TopicFetal BloodGene Expression ProfilingGene Expression Regulation, DevelopmentalGene Regulatory NetworksGenetic Predisposition to DiseaseGenome-Wide Association StudyHLA-C AntigensHumansBTN3A2 protein, humanButyrophilinsCathepsin HCTSH protein, humanHLA-C Antigens

Identifiers

PMID32724101
PMCPMC7387553
OpenAlexW3046025172

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.