ArticleScientific reports2020
Anti-biofilm efficacy of a medieval treatment for bacterial infection requires the combination of multiple ingredients.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- The Impacts of Ramadan Intermittent Fasting on Saliva Flow-Rate and Metabolic Data: A Systematic Review.Frontiers in nutrition · 2022Pooled it
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- Antibacterial activity of alginate-casein nanocapsules containing allicin against multidrug-resistant Pseudomonas aeruginosa.International microbiology : the official journal of the Spanish Society for Microbiology · 2025Article
- Ophthalmology in the Ebers Papyrus: a translation-based reassessment of ancient Egyptian eye remedies.Eye (London, England) · 2025Article
- Reviving the past for a healthier future: ancient molecules and remedies as a solution to the antibiotic crisis.Future microbiology · 2025Review
- Simulated Media for Mimicking the Human Environment In Vitro.APMIS : acta pathologica, microbiologica, et immunologica Scandinavica · 2025Review
- How Does Airway Surface Liquid Composition Vary in Different Pulmonary Diseases, and How Can We Use This Knowledge to Model Microbial Infections?Microorganisms · 2024Review
- Human-Derived collagen hydrogel as an antibiotic vehicle for topical treatment of bacterial biofilms.PloS one · 2024Article
- Review
- Combined Ferromagnetic Nanoparticles for Effective Periodontal Biofilm Eradication in Rat Model.International journal of nanomedicine · 2023Article
- A case study of the Ancientbiotics collaboration.Patterns (New York, N.Y.) · 2022Review
- Phase 1 safety trial of a natural product cocktail with antibacterial activity in human volunteers.Scientific reports · 2022Article
- Natural Strategies as Potential Weapons against Bacterial Biofilms.Life (Basel, Switzerland) · 2022Review
- Unleashing high content screening in hit detection - Benchmarking AI workflows including novelty detection.Computational and structural biotechnology journal · 2022Article
- The safety profile of Bald's eyesalve for the treatment of bacterial infections.Scientific reports · 2020Article
- From Treatise to Test: Evaluating Traditional Remedies for Anti-Biofilm Potential.Frontiers in pharmacology · 2020Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
Novel antimicrobials are urgently needed to combat drug-resistant bacteria and to overcome the inherent difficulties in treating biofilm-associated infections. Studying plants and other natural materials used in historical infection remedies may enable further discoveries to help fill the antibiotic discovery gap. We previously reconstructed a 1,000-year-old remedy containing onion, garlic, wine, and bile salts, known as 'Bald's eyesalve', and showed it had promising antibacterial activity. In this current paper, we have found this bactericidal activity extends to a range of Gram-negative and Gram-positive wound pathogens in planktonic culture and, crucially, that this activity is maintained against Acinetobacter baumannii, Stenotrophomonas maltophilia, Staphylococcus aureus, Staphylococcus epidermidis and Streptococcus pyogenes in a soft-tissue wound biofilm model. While the presence of garlic in the mixture can explain the activity against planktonic cultures, garlic has no activity against biofilms. We have found the potent anti-biofilm activity of Bald's eyesalve cannot be attributed to a single ingredient and requires the combination of all ingredients to achieve full activity. Our work highlights the need to explore not only single compounds but also mixtures of natural products for treating biofilm infections and underlines the importance of working with biofilm models when exploring natural products for the anti-biofilm pipeline.
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Registered trials
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