Evidence map›Paper›PMID 32724089›Full record

ArticleScientific reports2020

β1 integrin, ILK and mTOR regulate collagen synthesis in mechanically loaded tendon cells.

Rouhollah Mousavizadeh, Payman Hojabrpour, Felipe Eltit, Paul C McDonald, Shoukat Dedhar, Robert G McCormack, Vincent Duronio, Seyed Mehdi Jafarnejad, Alex Scott

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 1 pooled it
6.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 1 synthesis or guideline pooled it, 79 citations in OpenAlex.

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  4. Differential Transcriptomic and Adhesion Responses of Human Periodontal Ligament Cells to Cyclic and Static Hydrostatic Pressure.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Rouhollah MousavizadehDepartment of Physical Therapy, Centre for Hip Health and Mobility, University of British Columbia, 2635 Laurel Street, Vancouver, BC, V5Z 1M9, Canada.
Payman HojabrpourDepartment of Medicine, University of British Columbia, Vancouver, BC, Canada.
Felipe EltitDepartment of Materials Engineering, University of British Columbia, Vancouver, BC, Canada.
Paul C McDonaldDepartment of Integrative Oncology, BC Cancer Research Centre, Vancouver, BC, Canada.
Shoukat DedharDepartment of Integrative Oncology, BC Cancer Research Centre, Vancouver, BC, Canada.
Robert G McCormackDepartment of Orthopaedics, University of British Columbia, Vancouver, BC, Canada.
Vincent DuronioDepartment of Medicine, University of British Columbia, Vancouver, BC, Canada.
Seyed Mehdi JafarnejadPatrick G. Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, Northern Ireland, UK.
Alex ScottDepartment of Physical Therapy, Centre for Hip Health and Mobility, University of British Columbia, 2635 Laurel Street, Vancouver, BC, V5Z 1M9, Canada. alex.scott@ubc.ca.
University of British Columbia · CAQueen's University Belfast · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tendons are specialized tissues composed primarily of load-responsive fibroblasts (tenocytes) embedded in a collagen-rich extracellular matrix. Habitual mechanical loading or targeted exercise causes tendon cells to increase the stiffness of the extracellular matrix; this adaptation may occur in part through collagen synthesis or remodeling. Integrins are likely to play an important role in transmitting mechanical stimuli from the extracellular matrix to tendon cells, thereby triggering cell signaling pathways which lead to adaptive regulation of mRNA translation and protein synthesis. In this study, we discovered that mechanical stimulation of integrin β1 leads to the phosphorylation of AKT, an event which required the presence of integrin-linked kinase (ILK). Repetitive stretching of tendon cells activates the AKT and mTOR pathways, which in turn regulates mRNA translation and collagen expression. These results support a model in which integrins are an upstream component of the mechanosensory cellular apparatus, regulating fundamental tendon cell functions relevant to exercise-induced adaptation and mechanotherapy.

Indexed as

Bioartificial OrgansMechanotransduction, CellularAdultBiomechanical PhenomenaCell SurvivalCollagenFibroblastsHumansIntegrin beta1MalePhosphorylationProtein Serine-Threonine KinasesScaffold Protein ILKSignal TransductionTendonsTOR Serine-Threonine KinasesCollagenIntegrin beta1Itgb1 protein, humanMTOR protein, humanProtein Serine-Threonine KinasesScaffold Protein ILKTOR Serine-Threonine Kinases

Identifiers

PMID32724089
PMCPMC7387456
OpenAlexW3046049502

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.