ArticleThe Journal of biological chemistry2020
Discovery of a heme-binding domain in a neuronal voltage-gated potassium channel.
Erratum issuedOpen access · hybridAbstract read
In one paragraph
Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 17 papers.
0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- Chlorpromazine inhibits EAG1 channels by altering the interdomain coupling.Biophysical journal · 2026Article
- An extended network for regulation of heme homeostasis in cells.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Cell Settling, Migration, and Stochastic Cancer Gene Expression Suggest Potassium Membrane Flux May Initiate pH Reversal.Biomolecules · 2025Article
- Cytochrome C-like Domain Within the Human BK Channel.International journal of molecular sciences · 2025Article
- Heme regulates protein interactions and phosphorylation of BACH2 intrinsically disordered region in humoral response.iScience · 2025Article
- The Neural Palette of Heme: Altered Heme Homeostasis Underlies Defective Neurotransmission, Increased Oxidative Stress, and Disease Pathogenesis.Antioxidants (Basel, Switzerland) · 2024Review
- Use of Surface Plasmon Resonance Technique for Studies of Inter-domain Interactions in Ion Channels.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Origin and functional diversification of PAS domain, a ubiquitous intracellular sensor.Science advances · 2023Article
- Article
- Depletion assisted hemin affinity (DAsHA) proteomics reveals an expanded landscape of heme-binding proteins in the human proteome.Metallomics : integrated biometal science · 2023Article
- Extracellular hemin is a reverse use-dependent gating modifier of cardiac voltage-gated NaBiological chemistry · 2022Article
- Intracellular hemin is a potent inhibitor of the voltage-gated potassium channel Kv10.1.Scientific reports · 2022Article
- Carbon Monoxide Signaling: Examining Its Engagement with Various Molecular Targets in the Context of Binding Affinity, Concentration, and Biologic Response.Pharmacological reviews · 2022Review
- Conformation-sensitive antibody reveals an altered cytosolic PAS/CNBh assembly during hERG channel gating.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Endogenous Hemoprotein-Dependent Signaling Pathways of Nitric Oxide and Nitrite.Inorganic chemistry · 2021Review
- Review
- Mitochondrial Metal Ion Transport in Cell Metabolism and Disease.International journal of molecular sciences · 2021Review
Corrections and comments
- Erratum issued
Authors and funding
19 authors at 4 institutions in 2 countries.
Mark J BurtonDepartment of Chemistry, University of Leicester, Leicester, United Kingdom; Leicester Institute of Structural and Chemical Biology, University of Leicester, Leicester, United Kingdom.
Joel Cresser-BrownSchool of Chemistry, University of Bristol, Bristol, United Kingdom.
Morgan ThomasDepartment of Chemistry, University of Leicester, Leicester, United Kingdom; Leicester Institute of Structural and Chemical Biology, University of Leicester, Leicester, United Kingdom.
Nicola PortolanoDepartment of Chemistry, University of Leicester, Leicester, United Kingdom; Leicester Institute of Structural and Chemical Biology, University of Leicester, Leicester, United Kingdom.
Jaswir BasranLeicester Institute of Structural and Chemical Biology, University of Leicester, Leicester, United Kingdom; Department of Molecular and Cell Biology, University of Leicester, Leicester, United Kingdom.
Samuel L FreemanSchool of Chemistry, University of Bristol, Bristol, United Kingdom.
Hanna KwonSchool of Chemistry, University of Bristol, Bristol, United Kingdom.
Andrew R BottrillProtein Nucleic Acid Chemistry Laboratory, University of Leicester, Leicester, United Kingdom.
Manuel J Llansola-PortolesUniversité Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell, Gif-sur-Yvette, France.
Andrew A PascalUniversité Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell, Gif-sur-Yvette, France.
Rebekah Jukes-JonesMedical Research Council Toxicology Unit, University of Cambridge, Leicester, United Kingdom.
Tatyana ChernovaMedical Research Council Toxicology Unit, University of Cambridge, Leicester, United Kingdom.
Ralf SchmidLeicester Institute of Structural and Chemical Biology, University of Leicester, Leicester, United Kingdom; Department of Molecular and Cell Biology, University of Leicester, Leicester, United Kingdom.
Noel W DaviesLeicester Institute of Structural and Chemical Biology, University of Leicester, Leicester, United Kingdom; Department of Molecular and Cell Biology, University of Leicester, Leicester, United Kingdom.
Nina M StoreyLeicester Institute of Structural and Chemical Biology, University of Leicester, Leicester, United Kingdom; Department of Molecular and Cell Biology, University of Leicester, Leicester, United Kingdom.
Pierre DorletCNRS, Aix Marseille Université, Laboratoire de Bioenergetique et d'Ingenierie des Protéines, Marseille, France.
Peter C E MoodyDepartment of Molecular and Cell Biology, University of Leicester, Leicester, United Kingdom.
John S MitchesonDepartment of Molecular and Cell Biology, University of Leicester, Leicester, United Kingdom.
Emma L RavenSchool of Chemistry, University of Bristol, Bristol, United Kingdom. Electronic address: emma.raven@bristol.ac.uk.
University of Leicester · GBUniversity of Bristol · GBCentre National de la Recherche Scientifique · FRUniversity of Cambridge · GB
Funding
Biotechnology and Biological Sciences Research Council BB/K000128/1Biotechnology and Biological Sciences Research Council BB/M018598/1
Abstract
The EAG (
Indexed as
Cerebral CortexEther-A-Go-Go Potassium ChannelsHemeHumansNeuronsProtein BindingProtein DomainsEther-A-Go-Go Potassium ChannelsHemeKCNH7 protein, humanCap domainhemeheme regulationhERGhERG3ion channelPAS domainprotein crystallizationX-ray crystallography
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.