ArticleGynecologic oncology2020
Women who develop ovarian cancer show an increase in serum calcium and a decrease in serum albumin. A longitudinal study in the Janus Serum Bank Cohort.
Article in Gynecologic oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 15 citations in OpenAlex.
- Clinical value of preoperative serum calcium level in predicting deep infiltrative endometriosis among ovarian endometrioma.Annals of medicine · 2025Observational
- Distinct Chemical Cues Reprogram Cellular and Multicellular Phenotypes in Ovarian Cancer Spheroids.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- Machine-Learning-Assisted Analysis of Patient Clinical Biomarkers to Improve Ovarian Cancer Diagnosis.Precision chemistry · 2025Article
- Article
- Biological characteristics of spontaneous ovarian cancer inZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025Article
- Article
- Calcium-Related Genes Predicting Outcomes and Serving as Therapeutic Targets in Endometrial Cancer.Cells · 2022Article
- Integrated weighted gene co-expression network analysis reveals biomarkers associated with prognosis of high-grade serous ovarian cancer.Journal of clinical laboratory analysis · 2022Article
- L-shaped association of serum calcium with all-cause and CVD mortality in the US adults: A population-based prospective cohort study.Frontiers in nutrition · 2022Article
- Association between pre-diagnostic serum albumin and cancer risk: Results from a prospective population-based study.Cancer medicine · 2021Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundOvarian cancer is associated with high serum calcium and low serum albumin in clinical and epidemiologic studies. Whether high calcium and low albumin predispose to ovarian cancer or reflect existing cancer is unclear.
objectiveTest the hypothesis that serum calcium increases and serum albumin decreases in women who develop ovarian cancer.
methodsTwo hundred and four women donated sera to the Janus Serum Bank in Norway pre- and post-diagnosis of ovarian cancer, donations separated by approximately 14 years. We measured calcium and albumin in these sera and calculated the albumin-corrected calcium. Sera were adjusted for patient age and storage time.
resultsPost-diagnosis, mean age- and storage-adjusted calcium increased, from 2.53 to 2.68 mmol/L (p < .001). Mean age- and storage-adjusted, albumin-corrected calcium increased from 2.3 to 2.7 mmol/L (p < .001). Conversely, mean age- and storage-adjusted albumin decreased, from a mean of 51.3 to 40.9 g/L (p < .001). Significant changes were observed in women with early stage and metastatic cancer.
conclusionsThese data support the hypothesis that calcium and albumin are serum biomarkers of extant ovarian cancer. Longitudinal changes in calcium and albumin may be useful in ovarian cancer early detection.
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