ArticleeLife2020
Notch and TLR signaling coordinate monocyte cell fate and inflammation.
Open access · goldAbstract read
In one paragraph
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
3.9field-weighted citation impact, top 5% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 70 citations in OpenAlex.
- Canonical Notch2 signaling regulates development and maintenance of iron-recycling macrophages and iron homeostasis.Nature communications · 2026Article
- Evaluating the diagnostic and prognostic utility of serum DLL1 in acute-on-chronic liver failure patients with bacterial infections.Frontiers in medicine · 2026Article
- Systematic monocyte subset analysis reveals differential contribution of Notch signaling components to monocyte heterogeneity.iScience · 2025Article
- Toll-like Receptor Activation Remodels the Polyamine and Tryptophan Metabolism in Porcine Macrophages.Metabolites · 2025Article
- Notch1 siRNA and AMD3100 Ameliorate Metabolic Dysfunction-Associated Steatotic Liver Disease.Biomedicines · 2025Article
- Targeting toll-like receptors: unveiling potential therapeutic strategies for deep vein thrombosis.Frontiers in immunology · 2025Review
- RECK as a Potential Crucial Molecule for the Targeted Treatment of Sepsis.Journal of inflammation research · 2025Review
- Quantitative characterization of immune cells by measuring cellular signal transduction pathway activity.Scientific reports · 2024Article
- YY1 knockout in pro-B cells impairs lineage commitment, enabling unusual hematopoietic lineage plasticity.Genes & development · 2024Article
- Inducible CCR2+ nonclassical monocytes mediate the regression of cancer metastasis.The Journal of clinical investigation · 2024Article
- Single-cell multiomic analysis identifies macrophage subpopulations in promoting cardiac repair.The Journal of clinical investigation · 2024Article
- Notch 2 signaling contributes to intestinal eosinophil adaptations in steady state and tissue burden following oral allergen challenge.Journal of leukocyte biology · 2024Article
- Transcription factor C/EBPα is required for the development of Ly6CProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Article
- Primary cilia in Parkinson's disease: summative roles in signaling pathways, genes, defective mitochondrial function, and substantia nigra dopaminergic neurons.Frontiers in aging neuroscience · 2024Review
- Unravelling monocyte functions: from the guardians of health to the regulators of disease.Discovery immunology · 2024Review
- Regulation of toll-like receptor (TLR) signaling pathways in atherosclerosis: from mechanisms to targeted therapeutics.Acta pharmacologica Sinica · 2023Review
- Monocyte-related cytokines/chemokines in cerebral ischemic stroke.CNS neuroscience & therapeutics · 2023Review
- Macrophage polarization in spinal cord injury repair and the possible role of microRNAs: A review.Heliyon · 2023Review
- Monocyte regulation by gut microbial signals.Trends in microbiology · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 4 institutions in 1 country.
Jaba GamrekelashviliVascular Medicine Research, Hannover Medical School, Hannover, Germany.ORCID 0000-0001-7533-6906
Tamar KapanadzeVascular Medicine Research, Hannover Medical School, Hannover, Germany.
Stefan SablotnyVascular Medicine Research, Hannover Medical School, Hannover, Germany.
Corina RatiuInstitut für Kardiovaskuläre Physiologie, Fachbereich Medizin der Goethe-Universität Frankfurt am Main, Frankfurt am Main, Germany.
Khaled DastagirVascular Medicine Research, Hannover Medical School, Hannover, Germany.
Matthias LochnerInstitute of Medical Microbiology and Hospital Epidemiology, Hannover Medical School, Hannover, Germany.
Susanne KarbachCenter for Cardiology, Cardiology I, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.
Philip WenzelCenter for Cardiology, Cardiology I, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.
Andre SitnowVascular Medicine Research, Hannover Medical School, Hannover, Germany.
Susanne FleigVascular Medicine Research, Hannover Medical School, Hannover, Germany.
Tim SparwasserDepartment of Medical Microbiology and Hygiene, Medical Center of the Johannes Gutenberg-University of Mainz, Mainz, Germany.
Ulrich KalinkeInstitute for Experimental Infection Research, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Helmholtz Centre for Infection Research Braunschweig and the Hannover Medical School, Hannover, Germany.
Bernhard HolzmannDepartment of Surgery, Klinikum rechts der Isar, Technical University Munich, Munich, Germany.
Hermann HallerVascular Medicine Research, Hannover Medical School, Hannover, Germany.
Florian P LimbourgVascular Medicine Research, Hannover Medical School, Hannover, Germany.ORCID 0000-0002-8313-7226
Medizinische Hochschule Hannover · DEJohannes Gutenberg University Mainz · DEGoethe University Frankfurt · DETUM Klinikum · DE
Funding
Deutsche Forschungsgemeinschaft GA 2443/2-1Deutsche Forschungsgemeinschaft Li948-7/1Deutsche Stiftung für Herzforschung F/17/16
Abstract
Conventional Ly6C
Indexed as
Cell DifferentiationAnimalsInflammationMembrane GlycoproteinsMiceMonocytesReceptor, Notch2Signal TransductionToll-Like Receptor 7Membrane GlycoproteinsNotch2 protein, mouseReceptor, Notch2Tlr7 protein, mouseToll-Like Receptor 7immunologyinflammationmacrophage differentiationmonocytes and macrophagesmousenotch signalingTLR signaling
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.