ArticleeLife2020
Cryo-EM structures of human ZnT8 in both outward- and inward-facing conformations.
Open access · goldAbstract read
In one paragraph
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
7.6field-weighted citation impact, top 3% of its field
What it found
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Who cites it
45 citing papers in PubMed, 79 citations in OpenAlex.
- Exploring the conformational landscape of adenylate kinase and beyond with protein folding models.Scientific reports · 2026Article
- Loss-of-function variant of SLC30A8 rs13266634 (C > T) protects against type 2 diabetes by stabilizing ZnT8: Insights from epidemiological and computational analyses.Journal, genetic engineering & biotechnology · 2025Article
- Complete loss of SLC30A8 in humans improves glucose metabolism and beta cell function.Diabetologia · 2025Article
- Bardoxolone methyl blocks the efflux of Zn2+ by targeting hZnT1 to inhibit the proliferation and metastasis of cervical cancer.Protein & cell · 2025Article
- Memorization bias impacts modeling of alternative conformational states of solute carrier membrane proteins with methods from deep learning.PLoS computational biology · 2025Article
- The SLC-ome of membrane transport: From molecular discovery to physiology and clinical applications.Physiological reviews · 2025Review
- Molecular mechanisms of SLC30A10-mediated manganese transport.Nature communications · 2025Article
- Structural and functional insights of ZnT1 C-terminal domain as a regulator of zinc transport.Scientific reports · 2025Article
- A Compound Screen Based on Isogenic hESC-Derived β Cell Reveals an Inhibitor Targeting ZnT8-Mediated Zinc Transportation to Protect Pancreatic β Cell from Stress-Induced Cell Death.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Memorization Bias Impacts Modeling of Alternative Conformational States of Symmetric Solute Carrier Membrane Proteins with Methods from Deep Learning.bioRxiv : the preprint server for biology · 2025Article
- Cryo-EM structures of the zinc transporters ZnT3 and ZnT4 provide insights into their transport mechanisms.FEBS letters · 2025Article
- SLC30 (ZnT) and SLC39 (ZIP) zinc transporter families: from gatekeepers of zinc homeostasis to promoters of tumorigenesis and targets for clinical therapy.Frontiers in immunology · 2025Review
- The Intestinal Transporter SLC30A1 Plays a Critical Role in Regulating Systemic Zinc Homeostasis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Structural insights into human zinc transporter ZnT1 mediated ZnEMBO reports · 2024Article
- Upregulation of Intracellular Zinc Ion Level after Differentiation of the Neural Stem/Progenitor Cells In Vitro with the Changes in Gene Expression of Zinc Transporters.Biological trace element research · 2024Article
- Evolution, classification, and mechanisms of transport, activity regulation, and substrate specificity of ZIP metal transporters.Critical reviews in biochemistry and molecular biology · 2024Review
- Emerging Perspectives in Zinc Transporter Research in Prostate Cancer: An Updated Review.Nutrients · 2024Review
- Structural insights into the calcium-coupled zinc export of human ZnT1.Science advances · 2024Article
- Structures, Mechanisms, and Physiological Functions of Zinc Transporters in Different Biological Kingdoms.International journal of molecular sciences · 2024Review
- Metalation and activation of ZnBiophysics reviews · 2023Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Jing XueHoward Hughes Medical Institute and Department of Physiology, University of Texas Southwestern Medical Center, Dallas, United States.ORCID 0000-0002-7331-1382
Tian XieDepartment of Biophysics, University of Texas Southwestern Medical Center, Dallas, United States.ORCID 0000-0002-5445-664X
Weizhong ZengHoward Hughes Medical Institute and Department of Physiology, University of Texas Southwestern Medical Center, Dallas, United States.
Youxing JiangHoward Hughes Medical Institute and Department of Physiology, University of Texas Southwestern Medical Center, Dallas, United States.ORCID 0000-0002-1874-0504
Xiao-Chen BaiDepartment of Biophysics, University of Texas Southwestern Medical Center, Dallas, United States.ORCID 0000-0002-4234-5686
Howard Hughes Medical Institute · USThe University of Texas Southwestern Medical Center · US
Funding
Structural mechanisms of ion selectivity and gating in tetrameric cation channelsR01GM079179 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI JIANG, YOUXING · 2007 to 2019
$3.5MStructural and Functional Analyses of the Full-length Insulin Receptor (IR) and Type 1 Insulin-like Growth Factor Receptor (IGF1R) in the Liganded Active StateR01GM136976 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI BAI, XIAOCHEN · 2020 to 2024
$1.8MCancer Prevention and Research Institute of Texas RP160082Howard Hughes Medical InstituteNIGMS NIH HHS GM079179NIGMS NIH HHS R01 GM079179NIGMS NIH HHS R01 GM136976NIGMS NIH HHS R01GM136976Welch Foundation I-1578Welch Foundation I-1944
Abstract
ZnT8 is a Zn
Indexed as
Amino Acid SequenceAnimalsAntiportersBinding SitesCryoelectron MicroscopyHEK293 CellsHumansModels, MolecularProtein ConformationProtein DomainsSequence AlignmentZincZinc Transporter 8AntiportersSLC30A8 protein, humanZincZinc Transporter 8cryo-EMhumaninsulin secretory granulesmolecular biophysicsstructural biologyzinc transporterZnT8
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.