Evidence map›Paper›PMID 32723380›Full record

ArticleBMC cancer2020

Low dose environmental radon exposure and breast tumor gene expression.

Cheng Peng, Natalie DuPre, Trang VoPham, Yujing J Heng, Gabrielle M Baker, Christopher A Rubadue, Kimberly Glass, Abhijeet Sonawane, Oana Zeleznik, Peter Kraft and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Cheng PengChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA. recpe@channing.harvard.edu.ORCID http://orcid.org/0000-0002-0220-5128
Natalie DuPreChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Trang VoPhamChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Yujing J HengDepartment of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Gabrielle M BakerDepartment of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Christopher A RubadueDepartment of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Kimberly GlassChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Abhijeet SonawaneChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Oana ZeleznikChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Peter KraftDepartment of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
Susan E HankinsonChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA.
A Heather EliassenChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Jaime E HartChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Francine LadenChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Rulla M TamimiChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Brigham and Women's Hospital · USBeth Israel Deaconess Medical Center · USHarvard University · US

Funding

Statistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ROSNER, BERNARD A · 2000 to 2019
$77.8M
Life Course Cancer Epidemiology Cohort in WomenU01CA176726 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI ELIASSEN, A. HEATHER, WILLETT, WALTER C. · 2018 to 2025
$22.4M
Long Term Multidisciplinary Study of Cancer in Women: The Nurses Health StudyUM1CA186107 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, STAMPFER, MEIR · 2014 to 2023
$22.3M
Training Program in Cancer EpidemiologyT32CA009001 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI A. Heather Eliassen, Meir Stampfer · 1985 to 2026
$17.3M
Life Course Cancer Epidemiology Cohort in WomenUM1CA176726 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI WILLETT, WALTER C. · 2013 to 2017
$15.7M
Epidemiologic StudiesU19CA148065 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI AHSAN, HABIBUL, BRUGGE, JOAN SIEFERT · 2010 to 2014
$10.6M
Assessing the role of androgens in breast cancer riskR01CA166666 · NCI · UNIVERSITY OF MASSACHUSETTS AMHERST · PI HANKINSON, SUSAN E · 2012 to 2015
$1.7M
NCI NIH HHS P01 CA087969NCI NIH HHS P01 CA87969NCI NIH HHS R01 CA166666NCI NIH HHS T32 CA009001NCI NIH HHS U01 CA176726NCI NIH HHS U19 CA148065NCI NIH HHS UM1 CA176726NCI NIH HHS UM1 CA186107NIH HHS NIH T32 CA09001Susan G. Komen IIR13264020Susan G. Komen SAC110014
6 · The paper itself

Abstract

backgroundThe International Agency for Research on Cancer classified radon and its decay-products as Group-1-human-carcinogens, and with the current knowledge they are linked specifically to lung cancer. Biokinetic models predict that radon could deliver a carcinogenic dose to breast tissue. Our previous work suggested that low-dose radon was associated with estrogen-receptor (ER)-negative breast cancer risk. However, there is limited research to examine the role of radon in breast cancer biology at the tissue level. We aim to understand molecular pathways linking radon exposure with breast cancer biology using transcriptome-wide-gene-expression from breast tumor and normal-adjacent tissues.

methodsOur study included 943 women diagnosed with breast cancer from the Nurses' Health Study (NHS) and NHSII. We estimated cumulative radon concentration for each participant up-to the year of breast cancer diagnosis by linking residential addresses with a radon exposure model. Transcriptome-wide-gene-expression was measured with the Affymetrix-Glue-Human-Transcriptome-Array-3.0 and Human-Transcriptome-Array-2.0. We performed covariate-adjusted linear-regression for individual genes and further employed pathway-analysis. All analyses were conducted separately for tumor and normal-adjacent samples and by ER-status.

resultsNo individual gene was associated with cumulative radon exposure in ER-positive tumor, ER-negative tumor, or ER-negative normal-adjacent tissues at FDR < 5%. In ER-positive normal-adjacent samples, PLCH2-reached transcriptome-wide-significance (FDR < 5%). Gene-set-enrichment-analyses identified 2-upregulated pathways (MAPK signaling and phosphocholine biosynthesis) enriched at FDR < 25% in ER-negative tumors and normal-adjacent tissues, and both pathways have been previously reported to play key roles in ionizing radiation induced tumorigenesis in experimental settings.

conclusionOur findings provide insights into the molecular pathways of radon exposure that may influence breast cancer etiology.

Indexed as

AdultBreastBreast NeoplasmsCarcinogens, EnvironmentalEnvironmental ExposureFemaleGene ExpressionHumansLongitudinal StudiesMiddle AgedNon-SmokersRadiation ExposureRadonReceptors, EstrogenTranscriptomeCarcinogens, EnvironmentalRadonReceptors, EstrogenBreast cancer riskLow-dose radonTumor gene expression

Identifiers

PMID32723380
PMCPMC7385902
OpenAlexW3045868614

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.