Evidence map›Paper›PMID 32723374›Full record

Trial reportBMC nephrology2020

Mannitol and renal graft injury in patients undergoing deceased donor renal transplantation - a randomized controlled clinical trial.

Christian Reiterer, Karin Hu, Samir Sljivic, Markus Falkner von Sonnenburg, Edith Fleischmann, Alexander Kainz, Barbara Kabon

2 registry-linked trialsOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC nephrology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02705573 phase3completednot on this map

Effects of Mannitol on Delayed Graft Function After Cadaveric Renal Transplantation

TypeinterventionalSponsorMedical University of ViennaRan2018 to 2018Enrolled34ConditionsKidney Transplantation, MannitolArmsMannitol
NCT04705402 naunknown statusnot on this mapstarted 2022, after this paper: background citation

A Prospective, Randomized, Double Blinded, Placebo Control Trial to Evaluate Efficacy of Intravenous Mannitol Use During Cadaveric Kidney Transplantation Prior to Kidney Reperfusion

TypeinterventionalSponsorRabin Medical CenterRan2022 to 2022Enrolled32ConditionsRenal DialysisArmsMannitol, Saline
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Christian ReitererDepartment of Anaesthesia, Intensive Care Medicine and Pain Medicine, Medical University of Vienna, Spitalgasse 23, 1090, Vienna, Austria.
Karin HuClinical Department of Nephrology and Dialysis, Medical University of Vienna, Vienna, Austria.
Samir SljivicDepartment of Anaesthesia, Intensive Care Medicine and Pain Medicine, Medical University of Vienna, Spitalgasse 23, 1090, Vienna, Austria.
Markus Falkner von SonnenburgDepartment of Anaesthesia, Intensive Care Medicine and Pain Medicine, Medical University of Vienna, Spitalgasse 23, 1090, Vienna, Austria.
Edith FleischmannDepartment of Anaesthesia, Intensive Care Medicine and Pain Medicine, Medical University of Vienna, Spitalgasse 23, 1090, Vienna, Austria. edith.fleischmann@meduniwien.ac.at.
Alexander KainzClinical Department of Nephrology and Dialysis, Medical University of Vienna, Vienna, Austria.
Barbara KabonDepartment of Anaesthesia, Intensive Care Medicine and Pain Medicine, Medical University of Vienna, Spitalgasse 23, 1090, Vienna, Austria.
Medical University of Vienna · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIschaemia/reperfusion (I/R) injury is associated with renal tissue damage during deceased donor renal transplantation. The effect of mannitol to reduce I/R injury during graft reperfusion in renal transplant recipients is based on weak evidence. We evaluated the effect of mannitol to reduce renal graft injury represented by 16 serum biomarkers, which are indicators for different important pathophysiological pathways. Our primary outcome were differences in biomarker concentrations between the mannitol and the placebo group 24 h after graft reperfusion. Additionally, we performed a linear mixed linear model to account biomarker concentrations before renal transplantation.

methodsThirty-four patients undergoing deceased donor renal transplantation were randomly assigned to receive either 20% mannitol or 0.9% NaCl placebo solution before, during, and after graft reperfusion. Sixteen serum biomarkers (MMP1, CHI3L1, CCL2, MMP8, HGF, GH, FGF23, Tie2, VCAM1, TNFR1, IGFBP7, IL18, NGAL, Endostatin, CystC, KIM1) were measured preoperatively and 24 h after graft reperfusion using Luminex assays and ELISA.

resultsSixteen patients in each group were analysed. Tie2 differed 24 h after graft reperfusion between both groups (p = 0.011). Change of log2 transformed concentration levels over time differed significantly in four biomarkers (VCAM1,Endostatin, KIM1, GH; p = 0.007; p = 0.013; p = 0.004; p = 0.033; respectively) out of 16 between both groups.

conclusionThis study showed no effect of mannitol on I/R injury in patients undergoing deceased renal transplantation. Thus, we do not support the routinely use of mannitol to attenuate I/R injury.

trial registrationNCT02705573 . Registered on 10th March 2016.

Indexed as

AgedCadaverDiuretics, OsmoticEndostatinsFemaleFibroblast Growth Factor-23Hepatitis A Virus Cellular Receptor 1Human Growth HormoneHumansKidney Failure, ChronicKidney TransplantationMaleMannitolMiddle AgedReceptor, TIE-2Reperfusion InjuryDiuretics, OsmoticEndostatinsFGF23 protein, humanFibroblast Growth Factor-23HAVCR1 protein, humanHepatitis A Virus Cellular Receptor 1Human Growth HormoneMannitolReceptor, TIE-2TEK protein, humanVascular Cell Adhesion Molecule-1Biology-derived biomarkerI/R injuryMannitolRenal transplantationRenoprotection

Identifiers

PMID32723374
PMCPMC7388216
OpenAlexW3045713518

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.