ArticleNeural development2020
A novel temporal identity window generates alternating Eve
Article in Neural development, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 14 citations in OpenAlex.
- A non-transcriptional mitotic function of POU/Oct factors ensures spindle assembly and chromosome segregation.Journal of cell science · 2026Article
- The Hunchback transcription factor determines interneuron molecular identity, morphology, and presynapse targeting in the Drosophila NB5-2 lineage.PLoS biology · 2025Article
- The Drosophila homologue of CTIP1 (Bcl11a) and CTIP2 (Bcl11b) regulates neural stem cell temporal patterning.Development (Cambridge, England) · 2022Article
- Transcriptional profiling from whole embryos to single neuroblast lineages in Drosophila.Developmental biology · 2022Article
- Post-transcriptional regulation of transcription factor codes in immature neurons drives neuronal diversity.Cell reports · 2022Article
- Hunchback activates Bicoid in Pair1 neurons to regulate synapse number and locomotor circuit function.Current biology : CB · 2022Article
- Integrated Patterning Programs DuringAnnual review of neuroscience · 2021Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundSpatial patterning specifies neural progenitor identity, with further diversity generated by temporal patterning within individual progenitor lineages. In vertebrates, these mechanisms generate "cardinal classes" of neurons that share a transcription factor identity and common morphology. In Drosophila, two cardinal classes are Even-skipped (Eve)
methodsWe use a neuroblast specific Gal4 line, sparse labelling and molecular markers to identify an Nkx6
resultsLineage analysis identifies an Nkx6
conclusionsWe show that one neuroblast lineage generates interleaved cardinal motor neurons fates; that the Kr/Pdm TTFs form a novel temporal identity window that promotes expression of Nkx6; and that the Kr/Pdm > Nkx6 pathway is necessary and sufficient to promote VO motor neuron targeting to the correct ventral muscle group.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.