ArticleBMC veterinary research2020
The prevalence and mechanism of fluoroquinolone resistance in Escherichia coli isolated from swine farms in China.
Article in BMC veterinary research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 40 citations in OpenAlex.
- Two Multidrug-ResistantPathogens (Basel, Switzerland) · 2026Article
- Analysis of GyrA gene mutations in environmental Escherichia coli: understanding the mechanisms and spread of quinolone resistance in ecosystems.Die Naturwissenschaften · 2026Article
- Extended-Spectrum Beta-Lactamase (ESBL)-Producing E. coli in Livestock and Free-Roaming Wildlife: A Combined Phenotyping-Whole-Genome Sequencing One Health Approach.Transboundary and emerging diseases · 2026Article
- Resistance Mechanisms of Fluoroquinolone inAntibiotics (Basel, Switzerland) · 2025Article
- Biofilm Formation and Antibiotic Resistance Genes of Escherichia coli From Poultry Farms and Clinical Samples.Veterinary medicine and science · 2025Article
- Livestock Antibiotics Use and Antimicrobial Resistance.Antibiotics (Basel, Switzerland) · 2025Review
- 2002-2022 Quinolone Resistance inVeterinary sciences · 2025Review
- Observed Prevalence and Characterization of Fluoroquinolone-Resistant and Multidrug-Resistant Bacteria in Loggerhead Sea Turtles (Antibiotics (Basel, Switzerland) · 2025Article
- Assessment of the presence of multidrug-resistantHeliyon · 2024Article
- Navigating fluoroquinolone resistance in Gram-negative bacteria: a comprehensive evaluation.JAC-antimicrobial resistance · 2024Review
- Clonal and resistance profiles of fluoroquinolone-resistant uropathogenicFrontiers in microbiology · 2024Article
- Article
- Article
- The Distribution of Mobile Colistin-Resistant Genes, Carbapenemase-Encoding Genes, and Fluoroquinolone-Resistant Genes inAntibiotics (Basel, Switzerland) · 2022Article
- Molecular characteristics of fluoroquinolone-resistant Escherichia coli isolated from suckling piglets with colibacillosis.BMC microbiology · 2022Article
- Comparative Genomic Analysis of Antimicrobial-ResistantMicroorganisms · 2022Article
- Biological Effects of Quinolones: A Family of Broad-Spectrum Antimicrobial Agents.Molecules (Basel, Switzerland) · 2021Review
- Danofloxacin Treatment Alters the Diversity and Resistome Profile of Gut Microbiota in Calves.Microorganisms · 2021Article
- Prevalence of Antibiotic-ResistantAntibiotics (Basel, Switzerland) · 2021Article
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9 authors at 3 institutions in 1 country.
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Abstract
backgroundIt has been demonstrated that swine waste is an important reservoir for resistant genes. Moreover, the bacteria carrying resistant genes and originating from swine feces and wastewater could spread to the external environment. Fluoroquinolones (FQs) are widely used in livestock and poultry for the treatment of bacterial infection. However, resistance to FQs has increased markedly.
resultsIn this study, swine feces and wastewater were sampled from 21 swine farms of seven provinces in China to investigate the prevalence of FQ resistance, including plasmid-mediated fluoroquinolone resistance (PMQR) genes and the occurrence of target mutations. All isolates showed moderate rate of resistance to norfloxacin (43.0%), ciprofloxacin (47.6%), ofloxacin (47.0%) and levofloxacin (38.8%). The percentage of strains resistant to the four FQs antimicrobials was positively correlated with the danofloxacin (DANO) MIC. Among the 74 FQ-resistant isolates, 39 (52.70%) had mutations in gyrA (S83L and D87 to N, Y, G, or H), 21 (28.38%) had mutations in parC (S80I and E84K), 2 (2.70%) had mutations in parE (I355T and L416F), 26 (35.14%) had mutations in marR (D67N and G103S), 1 (1.35%) had mutations in acrR (V29G). While, no mutation was found in gyrB. There were 7 (9.46%) strains carried the qnrS gene, 29 (39.19%) strains carried the oqxAB gene, and 9 (12.16%) strains carried the aac (6')-Ib-cr gene. In addition, the conjugation assays showed that qnrS, oqxAB and aac (6')-Ib-cr could be successfully transferred to E. coli J53 from 4 (57.1%), 20 (69.0%) and 5 (55.6%) donor strains, respectively. There were no qnrA, qnrB, qnrC, qnrD and qepA genes detected.
conclusionThe present study showed that DANO-resistant E. coli strains isolated from swine farms had significant cross-resistance to other four FQs antimicrobials. Further study revealed that the resistance mechanisms of swine-derived E. coli to FQs may be attributable to the occurrence of chromosomal mutations (gyrA, parC, parE, marR and acrR genes double-site or single-site mutation) and the presence of PMQR genes (qnrS, oqxAB and aac (6')-Ib-cr). To the best of our knowledge, one novel mutation marR-D67N was found to be associated with FQ resistance, two mutations parE-L416F and acrR-V29G have never been reported in China.
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