ArticleThe journal of headache and pain2020
Altered hypothalamic functional connectivity in post-traumatic headache after mild traumatic brain injury.
Article in The journal of headache and pain, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Functional Connectivity Changes on Resting-State fMRI after Mild Traumatic Brain Injury: A Systematic Review.AJNR. American journal of neuroradiology · 2024Pooled it
- Establishing the link between post-concussive symptoms and brain network dysfunction: A systematic scoping review of neuroimaging evidence.NeuroImage. Clinical · 2026Article
- Suicide-related outcomes in veterans with post-traumatic headache: a retrospective cohort study.Lancet regional health. Americas · 2026Article
- Shared neural signatures of photophobia in migraine and post-traumatic headache: a task-based fMRI study.The journal of headache and pain · 2025Article
- Changes in cerebral cortex activation during upright standing tasks in individuals with chronic neck pain: an fNIRS study.Frontiers in neurology · 2025Article
- Brain structural and functional abnormalities associated with acute post-traumatic headache: iron deposition and functional connectivity.The journal of headache and pain · 2024Article
- Article
- Inflammation, brain connectivity, and neuromodulation in post-traumatic headache.Brain, behavior, & immunity - health · 2024Review
- Treatment effects of N-acetyl cysteine on resting-state functional MRI and cognitive performance in patients with chronic mild traumatic brain injury: a longitudinal study.Frontiers in neurology · 2024Article
- Art therapy and brain injury: making the invisible visible.Frontiers in psychology · 2024Article
- Traumatic brain injury: Mechanisms, manifestations, and visual sequelae.Frontiers in neuroscience · 2023Review
- Thalamic subfield iron accumulation after acute mild traumatic brain injury as a marker of future post-traumatic headache intensity.Headache · 2023Observational
- Abnormal interhemispheric functional connectivity in patients with primary dysmenorrhea: a resting-state functional MRI study.Quantitative imaging in medicine and surgery · 2022Article
- The value of brain MRI functional connectivity data in a machine learning classifier for distinguishing migraine from persistent post-traumatic headache.Frontiers in pain research (Lausanne, Switzerland) · 2022Article
- Identification of chronic mild traumatic brain injury using resting state functional MRI and machine learning techniques.Frontiers in neuroscience · 2022Article
- Disrupted hypothalamic functional connectivity related to cognitive impairment after diffuse axonal injury.Medicine · 2021Observational
- Hyperconnection and hyperperfusion of overlapping brain regions in patients with menstrual-related migraine: a multimodal neuroimaging study.Neuroradiology · 2021Article
- Using Longitudinal Variance Components Models to Assess Hyper-connectivity in Severe Traumatic Brain Injury Patients.Basic and clinical neuroscienceArticle
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6 authors at 1 institution in 1 country.
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Abstract
backgroundPost-traumatic headache (PTH) is one of the most frequent symptoms following mild traumatic brain injury (mTBI). Neuroimaging studies implicate hypothalamic function connectivity (FC) disruption as an important factor in pain disorders. However, it is unknown whether there are alterations in the hypothalamus-based resting state FC within PTH following mTBI at the acute stage and its relationship with headache symptom measurement.
methodsForty-four mTBI patients with PTH, 27 mTBI patients without PTH and 43 healthy controls who were well matched for age, gender, and years of education were enrolled in this study. All participants underwent resting-state functional magnetic resonance imaging (fMRI) scanning as well as headache symptom measurement and cognitive assessment. Hypothalamic resting state networks were characterized by using a standard seed-based whole-brain correlation method. The bilateral hypothalamic FC was compared among the three groups. Furthermore, the correlations between hypothalamic resting state networks and headache frequency, headache intensity and MoCA scores was investigated in mTBI patients with PTH using Pearson rank correlation.
resultsCompared with mTBI patients without PTH, mTBI patients with PTH at the acute stage presented significantly decreased left hypothalamus-based FC with the right middle frontal gyrus (MFG) and right medial superior frontal gyrus (mSFG), and significantly decreased right hypothalamus-based FC with the right MFG. Decreased FC of the right MFG was significantly positively associated with headache frequency and headache intensity (r = 0.339, p = 0.024; r = 0.408, p = 0.006, respectively). Decreased FC of the right mSFG was significantly positively associated with headache frequency and headache intensity (r = 0.740, p < 0.0001; r = 0.655, p < 0.0001, respectively).
conclusionOur data provided evidence of disrupted hypothalamic FC in patients with acute mTBI with PTH, while abnormal FC significantly correlated with headache symptom measurement. Taken together, these changes may play an essential role in the neuropathological mechanism of mTBI patients with PTH.
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