SynthesisThe Journal of international medical research2020
A meta-analysis of the local application of vancomycin powder to prevent surgical site infection after spinal surgeries.
Synthesis in The Journal of international medical research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 4 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Efficacy of powdered vancomycin in the prophylaxis of surgical site infections in posterior thoracic and/or lumbar spine surgery: a systematic review of randomized clinical trials with meta-analysis.Neurosurgical review · 2025Pooled it
- Does the Application of Topical Vancomycin Reduce Surgical Site Infections in Spine Surgery? A Meta-analysis of Randomized Controlled Trials.Clinical orthopaedics and related research · 2024Pooled it
- Effect of powdered vancomycin on stopping surgical site wound infections in neurosurgery: A meta-analysis.International wound journal · 2023Pooled it
- Irrigation techniques used in spine surgery for surgical site infection prophylaxis: a systematic review and meta-analysis.BMC musculoskeletal disorders · 2022Pooled it
- Postoperative wound complications and revisions in high-risk patients undergoing spine surgery with prophylactic muscle flap reconstruction: systematic review and meta-analysis.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Intrawound vancomycin powder in orthopaedic surgery after the VPIP trial: a critical reappraisal of efficacy, dosing, application plane, and antimicrobial stewardship.Journal of bone and joint infection · 2026Review
- Modulation of Surgical Site Infection Risk in Spinal and Thoracic Surgeries Through Operative Parameters: A Narrative Review.Journal of clinical medicine · 2025Review
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- Review
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- Spectrum of Surgical Site Infection Pathogens in Chronic Infectious Spondylitis Requiring Revision Surgery: A 5-Year Cohort Study.Journal of clinical medicine · 2024Article
- [Bone cement as a local antibiotic carrier].Orthopadie (Heidelberg, Germany) · 2023Review
- Surgical site infection in spinal surgery: a bibliometric analysis.Journal of orthopaedic surgery and research · 2023Article
- Intra-wound versus systemic vancomycin for preventing surgical site infection induced by methicillin-resistant S. aureus after spinal implant surgery in a rat model.Journal of orthopaedic surgery and research · 2023Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study aimed to systematically analyze the effectiveness and safety of the local application of vancomycin powder to prevent surgical site infection (SSI) after spinal surgeries and provide guidance for clinical practice.
methodsTwo researchers independently searched PubMed, Web of Science, Elsevier, and China National Knowledge Infrastructure using the MeSH terms "spinal surgery," "vancomycin," "local," "topical," "prophylactic," "surgical site infection," and "SSI" to identify studies published between January 2010 and January 2020 on the local application of vancomycin powder for preventing SSI after spinal surgeries. The outcome assessment indicators were analyzed using RevMan 5.3 software.
resultsThree randomized controlled trials, two prospective studies, and 26 retrospective studies were included in the current research. The results of the meta-analysis revealed significant differences between the vancomycin and control groups (non-vancomycin group) concerning the incidence of SSI (risk ratio = 0.39, 95% confidence interval = 0.28-0.55,
conclusionLocal application of vancomycin powder is an effective and safe method to prevent SSI after spinal surgeries.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.