ArticleUnited European gastroenterology journal2021
Gastroesophageal reflux after per-oral endoscopic myotomy is frequently asymptomatic, but leads to more severe esophagitis: A case-control study.
Article in United European gastroenterology journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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12 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Standard length of peroral endoscopic myotomy (POEM) for achalasia: a systematic review and meta-analysis.Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus · 2024Pooled it
- Trial
- Expert panel perspectives on management of GERD post esophageal POEM: a national survey study.Surgical endoscopy · 2026Article
- Asymptomatic Erosive Esophagitis.Digestive diseases and sciences · 2025Review
- Gastroesophageal reflux following peroral endoscopic myotomy for achalasia: Bumps in the road to success.World journal of gastroenterology · 2024Article
- Gastroesophageal reflux after per-oral endoscopic myotomy: Management literature.World journal of gastroenterology · 2024Article
- Prediction, prevention and management of gastroesophageal reflux after per-oral endoscopic myotomy: An update.World journal of gastroenterology · 2024Review
- Submucosal endoscopy: the present and future.Clinical endoscopy · 2023Review
- Achalasia.Nature reviews. Disease primers · 2022Review
- The Mechanisms for the Association of Cancer and Esophageal Dysmotility Disorders.Medical sciences (Basel, Switzerland) · 2021Review
- Achalasia: A mechanical and sensitivity disorder.United European gastroenterology journal · 2020Article
- Clinical efficacy and safety of short-length peroral endoscopic myotomy (POEM) compared with long-length myotomy for the treatment of achalasia.Therapeutic advances in gastrointestinal endoscopyArticle
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9 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimThe incidence of gastroesophageal reflux disease (GERD) is high after per-oral endoscopic myotomy (POEM). GERD after POEM may be qualitatively different from GERD in patients without motility disorders. In this study, we aimed to analyze and compare different aspects of GERD between patients with post-POEM GERD and nonachalasia GERD.
methodsThe data of patients with GERD after POEM (January 2018 to June 2019) were compared with that of a control group (nonachalasia GERD group), which included patients presenting with typical reflux symptoms without associated major motility disorders. Patients with lower esophageal sphincter pressure lower than 10 mmHg were excluded from the study. GERD was evaluated at 3 months after POEM. Esophageal acid exposure time higher than 4.2% was used to define GERD. The primary outcome of the study was comparison of GERD-related quality of life and reflux symptom severity between the two groups. In addition, the severity of erosive esophagitis and reflux-symptom association were also recorded in the two groups.
resultsA total of 100 patients were included in the study, with 50 patients in each group (post-POEM GERD vs. controls). The baseline parameters were comparable between the two groups. Median interquartile range of GERD-related quality of life score was significantly lower in the post-POEM group (11 [0-23.3] versus 34 [24-44]; p < 0.001). The post-POEM GERD group had significantly lower median heartburn (6.0 [0-16.3] versus 15.5 [7.5-24.8]; p = 0.001) and regurgitation scores (0 [0-6.0] versus 20.0 [12.3-25.0]; p < 0.001). Erosive esophagitis was more frequent in the post-POEM group (28 [56%] versus 10 [20.4%], p = 0.001). Only three (6%) patients in the post-POEM group had a positive reflux-symptom association as compared with 28 (56%) patients in the control group (p < 0.001).
conclusionIn selected patients with pH positive GERD after POEM, the symptoms are milder and reflux-symptom association is poor in spite of more severe esophagitis as compared with controls.
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